Insight into molecular basis of curing of [PSI+] prion by overexpression of 104-kDa heat shock protein (Hsp104).
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Sup35 methionine oxidation is a trigger for de novo [PSI(+)] prion formationYeast prions and human prion-like proteins: sequence features and prediction methodsYeast prions: structure, biology, and prion-handling systemsSensitivity-enhanced NMR reveals alterations in protein structure by cellular milieusCombining DNP NMR with segmental and specific labeling to study a yeast prion protein strain that is not parallel in-register.Distinct prion strains are defined by amyloid core structure and chaperone binding site dynamics.Heat shock protein 104 (Hsp104)-mediated curing of [PSI+] yeast prions depends on both [PSI+] conformation and the properties of the Hsp104 homologs.Hsp104 overexpression cures Saccharomyces cerevisiae [PSI+] by causing dissolution of the prion seedsLow activity of select Hsp104 mutants is sufficient to propagate unstable prion variantsThe effects of amino acid composition of glutamine-rich domains on amyloid formation and fragmentation.Heterologous gln/asn-rich proteins impede the propagation of yeast prions by altering chaperone availabilityDistinct amino acid compositional requirements for formation and maintenance of the [PSI⁺] prion in yeast.Heterologous aggregates promote de novo prion appearance via more than one mechanism.Stoichiometry and Affinity of Thioflavin T Binding to Sup35p Amyloid Fibrils.Prions in yeast.Distinct Prion Domain Sequences Ensure Efficient Amyloid Propagation by Promoting Chaperone Binding or Processing In Vivo.The story of stolen chaperones: how overexpression of Q/N proteins cures yeast prions.Physiological and environmental control of yeast prions.Mechanistic and Structural Insights into the Prion-Disaggregase Activity of Hsp104.Evidence of a prion-like transmission of p53 amyloid in Saccharomyces cerevisiae.Ribosome-bound Pub1 modulates stop codon decoding during translation termination in yeast.Prions, Chaperones, and Proteostasis in Yeast.DNA aptamers detecting generic amyloid epitopes.Protein Folding Activity of the Ribosome is involved in Yeast Prion Propagation.Extensive diversity of prion strains is defined by differential chaperone interactions and distinct amyloidogenic regions.The life of [PSI].A new perspective on Hsp104-mediated propagation and curing of the yeast prion [PSI (+) ].Surface adsorption considerations when working with amyloid fibrils in multiwell plates and Eppendorf tubesHsp70 targets Hsp100 chaperones to substrates for protein disaggregation and prion fragmentation.Hsp104 disaggregase at normal levels cures many [PSI+] prion variants in a process promoted by Sti1p, Hsp90, and Sis1p.A putative role of the Sup35p C-terminal domain in the cytoskeleton organization during yeast mitosis.Curing of [PSI+] by Hsp104 overexpression: clues to solving the puzzle.Over-expression of the molecular chaperone Hsp104 in Saccharomyces cerevisiae results in the malpartition of [PSI+ ] propagons.Molecular basis for diversification of yeast prion strain conformation.Variant-specific and reciprocal Hsp40 functions in Hsp104-mediated prion elimination.Amyloid fibrils embodying distinctive yeast prion phenotypes exhibit diverse morphologies.Protein Co-Aggregation Related to Amyloids: Methods of Investigation, Diversity, and Classification
P2860
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P2860
Insight into molecular basis of curing of [PSI+] prion by overexpression of 104-kDa heat shock protein (Hsp104).
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Insight into molecular basis o ...... a heat shock protein (Hsp104).
@ast
Insight into molecular basis o ...... a heat shock protein (Hsp104).
@en
type
label
Insight into molecular basis o ...... a heat shock protein (Hsp104).
@ast
Insight into molecular basis o ...... a heat shock protein (Hsp104).
@en
prefLabel
Insight into molecular basis o ...... a heat shock protein (Hsp104).
@ast
Insight into molecular basis o ...... a heat shock protein (Hsp104).
@en
P2860
P356
P1476
Insight into molecular basis o ...... a heat shock protein (Hsp104).
@en
P2093
Christopher W Helsen
John R Glover
P2860
P304
P356
10.1074/JBC.M111.302869
P407
P577
2011-11-11T00:00:00Z