Modulation of L-α-lysophosphatidylinositol/GPR55 mitogen-activated protein kinase (MAPK) signaling by cannabinoids. - Wikidata - wikimedia - TriplyDB

Modulation of L-α-lysophosphatidylinositol/GPR55 mitogen-activated protein kinase (MAPK) signaling by cannabinoids.

Modulation of L-α-lysophosphatidylinositol/GPR55 mitogen-activated protein kinase (MAPK) signaling by cannabinoids.

http://www.wikidata.org/entity/Q35643909

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The CB2-preferring agonist JWH015 also potently and efficaciously activates CB1 in autaptic hippocampal neurons Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation Targeting the endocannabinoid system with cannabinoid receptor agonists: pharmacological strategies and therapeutic possibilities Unravelling the molecular complexity of GPCR-mediated EGFR transactivation using functional genomics approaches The natural product magnolol as a lead structure for the development of potent cannabinoid receptor agonists Emerging targets in lipid-based therapy The roles of sphingosine kinase 1 and 2 in regulating the metabolome and survival of prostate cancer cells.The cannabinoid ligand LH-21 reduces anxiety and improves glucose handling in diet-induced obese pre-diabetic mice.Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling.Alteration of fatty-acid-metabolizing enzymes affects mitochondrial form and function in hereditary spastic paraplegia.Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands.The phytocannabinoid, Δ⁹-tetrahydrocannabivarin, can act through 5-HT₁A receptors to produce antipsychotic effects.GPR55 promotes migration and adhesion of colon cancer cells indicating a role in metastasis.Role of GPR55 during Axon Growth and Target Innervation.The antinociceptive triterpene β-amyrin inhibits 2-arachidonoylglycerol (2-AG) hydrolysis without directly targeting cannabinoid receptors.The endocannabinoids anandamide and virodhamine modulate the activity of the candidate cannabinoid receptor GPR55 Molecular Targets of the Phytocannabinoids: A Complex Picture.Off-target cannabinoid effects mediated by GPR55.Quantitative Analyses of Synergistic Responses between Cannabidiol and DNA-Damaging Agents on the Proliferation and Viability of Glioblastoma and Neural Progenitor Cells in Culture.Inhibition of COX-2-mediated eicosanoid production plays a major role in the anti-inflammatory effects of the endocannabinoid N-docosahexaenoylethanolamine (DHEA) in macrophages Molecular Pharmacology of Phytocannabinoids.Evaluation of the insulin releasing and antihyperglycaemic activities of GPR55 lipid agonists using clonal beta-cells, isolated pancreatic islets and mice An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol.Lysophospholipid Receptors, as Novel Conditional Danger Receptors and Homeostatic Receptors Modulate Inflammation-Novel Paradigm and Therapeutic Potential An integrated metabolomics approach for the research of new cerebrospinal fluid biomarkers of multiple sclerosis.(R,R')-4'-methoxy-1-naphthylfenoterol targets GPR55-mediated ligand internalization and impairs cancer cell motility Cannabinoid CB(2) receptor attenuates morphine-induced inflammatory responses in activated microglial cells.The G protein-coupled receptor 55 ligand l-α-lysophosphatidylinositol exerts microglia-dependent neuroprotection after excitotoxic lesion.A putative lysophosphatidylinositol receptor GPR55 modulates hippocampal synaptic plasticity.Two Janus Cannabinoids That Are Both CB2 Agonists and CB1 Antagonists.Cannabinoid CB2 Agonist GW405833 Suppresses Inflammatory and Neuropathic Pain through a CB1 Mechanism that is Independent of CB2 Receptors in Mice.GPR55-dependent stimulation of insulin secretion from isolated mouse and human islets of Langerhans.A Functional Assay for GPR55: Envision Protocol.Bicyclic imidazole-4-one derivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55

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Modulation of L-α-lysophosphatidylinositol/GPR55 mitogen-activated protein kinase (MAPK) signaling by cannabinoids.

http://www.wikidata.org/entity/Q35643909

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Modulation of L-α-lysophosphat ...... PK) signaling by cannabinoids.

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Modulation of L-α-lysophosphat ...... PK) signaling by cannabinoids.

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Modulation of L-α-lysophosphat ...... PK) signaling by cannabinoids.

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Journal of Biological Chemistry

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Modulation of L-α-lysophosphat ...... PK) signaling by cannabinoids.

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Andrew J Irving

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Gemma Baillie

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Iain R Greig

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Jürg Gertsch

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Roger G Pertwee

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Ruth A Ross

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Sharon Anavi-Goffer

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P2860

The GPR55 ligand L-alpha-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation

Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands

The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo

The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin

Beta-caryophyllene is a dietary cannabinoid

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current

Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay

The orphan receptor GPR55 is a novel cannabinoid receptor

Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design.

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22027819

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