Site-directed mutagenesis in the fingers subdomain of HIV-1 reverse transcriptase reveals a specific role for the beta3-beta4 hairpin loop in dNTP selection.
about
K70Q adds high-level tenofovir resistance to "Q151M complex" HIV reverse transcriptase through the enhanced discrimination mechanismStructural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir ResistanceProbing the active site steric flexibility of HIV-1 reverse transcriptase: different constraints for DNA- versus RNA-templated synthesis.Lys66 residue as a determinant of high mismatch extension and misinsertion rates of HIV-1 reverse transcriptase.Human immunodeficiency virus reverse transcriptase: 25 years of research, drug discovery, and promise.Utilization of a deoxynucleoside diphosphate substrate by HIV reverse transcriptase.The high cost of fidelity.The lysine 65 residue in HIV-1 reverse transcriptase function and in nucleoside analog drug resistance.K65R and K65A substitutions in HIV-1 reverse transcriptase enhance polymerase fidelity by decreasing both dNTP misinsertion and mispaired primer extension efficiencies.Selection and characterization of HIV-1 with a novel S68 deletion in reverse transcriptase.Thermostable HIV-1 group O reverse transcriptase variants with the same fidelity as murine leukaemia virus reverse transcriptase.DNA synthesis from diphosphate substrates by DNA polymerases.
P2860
Q21135752-15D95B78-7ECA-4BB8-B483-16B2E23E3846Q27657718-56E547B9-064E-4320-BBAD-8510C98B35F6Q34159959-DA805D61-ECBD-4A45-B0E7-89995AD582BBQ36319882-D12BE018-1623-4B6C-942A-6D27C9C62E69Q36435971-B86D8448-8E22-4F53-B9B0-C6F2B65ECC86Q36559563-D92D4926-4F5E-409E-9DDD-168A8FAAD991Q38158093-70184102-ABF5-434F-BA19-8F19AFB9AA2CQ38262356-1645D40F-30D9-46DF-B47D-4932A2C28586Q38343433-66EEEAA7-06EB-41D5-BE43-E4F91020B509Q42053218-F900775D-72D2-446E-83FD-9714DF44DAA1Q45367817-35442A10-E598-4995-BE84-31F5D7D04838Q48042595-C7548C07-27E6-41D1-80E3-32FB9ED76D23
P2860
Site-directed mutagenesis in the fingers subdomain of HIV-1 reverse transcriptase reveals a specific role for the beta3-beta4 hairpin loop in dNTP selection.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Site-directed mutagenesis in t ...... airpin loop in dNTP selection.
@ast
Site-directed mutagenesis in t ...... airpin loop in dNTP selection.
@en
type
label
Site-directed mutagenesis in t ...... airpin loop in dNTP selection.
@ast
Site-directed mutagenesis in t ...... airpin loop in dNTP selection.
@en
prefLabel
Site-directed mutagenesis in t ...... airpin loop in dNTP selection.
@ast
Site-directed mutagenesis in t ...... airpin loop in dNTP selection.
@en
P2093
P2860
P1476
Site-directed mutagenesis in t ...... airpin loop in dNTP selection.
@en
P2093
Eric T Kool
Michael A Parniak
Scott J Garforth
Tae Woo Kim
P2860
P356
10.1016/J.JMB.2006.09.057
P407
P577
2006-09-27T00:00:00Z