Of mice and MEN1: Insulinomas in a conditional mouse knockout. - Wikidata - wikimedia - TriplyDB

Of mice and MEN1: Insulinomas in a conditional mouse knockout.

Of mice and MEN1: Insulinomas in a conditional mouse knockout.

http://www.wikidata.org/entity/Q35660901

about

Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis.Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors RETRACTED: Betatrophin: a hormone that controls pancreatic β cell proliferation The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression.Inherited pancreatic endocrine tumor syndromes: advances in molecular pathogenesis, diagnosis, management, and controversies Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus Pancreas-specific Cre driver lines and considerations for their prudent use Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells Reexpression of oncoprotein MafB in proliferative β-cells and Men1 insulinomas in mouse Altered MENIN expression disrupts the MAFA differentiation pathway in insulinoma Mutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cells Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues miR-24 regulates menin in the endocrine pancreas Menin interacts with IQGAP1 to enhance intercellular adhesion of beta-cells.Mouse models of human familial cancer syndromes.Identification of somatic mutations in parathyroid tumors using whole-exome sequencing Menin/PRMT5/hedgehog signaling: a potential target for the treatment of multiple endocrine neoplasia type 1 tumors.Conditional deletion of p53 and Rb in the renin-expressing compartment of the pancreas leads to a highly penetrant metastatic pancreatic neuroendocrine carcinoma.Menin epigenetically represses Hedgehog signaling in MEN1 tumor syndrome.Pancreatic neuroendocrine tumors in glucagon receptor-deficient mice."RAS"ling β cells to proliferate for diabetes: why do we need MEN?Mouse models of endocrine tumours.Multiple endocrine neoplasia type 1 deletion in pancreatic alpha-cells leads to development of insulinomas in mice Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells.Reversal of preexisting hyperglycemia in diabetic mice by acute deletion of the Men1 gene.Telomere dysfunction suppresses multiple endocrine neoplasia in mice.Mouse models of inherited cancer syndromes Minireview: microRNA function in pancreatic β cells.Osteoblast menin regulates bone mass in vivo.Exploring the tumors of multiple endocrine neoplasia type 1 in mouse models for basic and preclinical studies Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1 Enteric neuron imbalance and proximal dysmotility in ganglionated intestine of the Sox10Dom/+ Hirschsprung mouse model.Multiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia.Ash1l controls quiescence and self-renewal potential in hematopoietic stem cells.The Cell Death Inhibitor ARC Is Induced in a Tissue-Specific Manner by Deletion of the Tumor Suppressor Gene Men1, but Not Required for Tumor Development and Growth.A simple matter of life and death-the trials of postnatal Beta-cell mass regulation Molecular genetics of multiple endocrine neoplasia types 1 and 2.Phenotypic Characterization of MIP-CreERT1Lphi Mice With Transgene-Driven Islet Expression of Human Growth Hormone Pro-oncogenic Roles of HLXB9 Protein in Insulinoma Cells through Interaction with Nono Protein and Down-regulation of the c-Met Inhibitor Cblb (Casitas B-lineage Lymphoma b).

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Of mice and MEN1: Insulinomas in a conditional mouse knockout.

http://www.wikidata.org/entity/Q35660901

description

2003 nî lūn-bûn

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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2003年论文

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2003年论文

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name

Of mice and MEN1: Insulinomas in a conditional mouse knockout.

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Of mice and MEN1: Insulinomas in a conditional mouse knockout.

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type

label

Of mice and MEN1: Insulinomas in a conditional mouse knockout.

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Of mice and MEN1: Insulinomas in a conditional mouse knockout.

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Of mice and MEN1: Insulinomas in a conditional mouse knockout.

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Of mice and MEN1: Insulinomas in a conditional mouse knockout.

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MCB.23.17.6075-6085.2003

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Molecular and Cellular Biology

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Of mice and MEN1: Insulinomas in a conditional mouse knockout.

@en

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A Lee Burns

http://www.w3.org/2001/XMLSchema#string

Allen M Spiegel

http://www.w3.org/2001/XMLSchema#string

Cristina Montagna

http://www.w3.org/2001/XMLSchema#string

Douglas Hanahan

http://www.w3.org/2001/XMLSchema#string

Gary P Swain

http://www.w3.org/2001/XMLSchema#string

Jeffrey H Hager

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Jerrold M Ward

http://www.w3.org/2001/XMLSchema#string

Judy S Crabtree

http://www.w3.org/2001/XMLSchema#string

Lisa Garrett-Beal

http://www.w3.org/2001/XMLSchema#string

Peter C Scacheri

http://www.w3.org/2001/XMLSchema#string

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Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription

Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling

Menin, a gene product responsible for multiple endocrine neoplasia type 1, interacts with the putative tumor metastasis suppressor nm23

Menin interacts directly with the homeobox-containing protein Pem

The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation

Menin, the product of the MEN1 gene, is a nuclear protein

The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene

Characterization of mutations in patients with multiple endocrine neoplasia type 1.

Germ line transmission of the Cdk4(R24C) mutation facilitates tumorigenesis and escape from cellular senescence.

Targeted oncogene activation by site-specific recombination in transgenic mice

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6075-6085

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scholarly article

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10.1128/MCB.23.17.6075-6085.2003

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17

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23

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Francis Collins

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2003-09-01T00:00:00Z

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12917331

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180910

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