Site-Specific Phosphorylation of VEGFR2 Is Mediated by Receptor Trafficking: Insights from a Computational Model
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Molecular mechanism matters: Benefits of mechanistic computational models for drug development.Computational investigation of sphingosine kinase 1 (SphK1) and calcium dependent ERK1/2 activation downstream of VEGFR2 in endothelial cells.A computational analysis of in vivo VEGFR activation by multiple co-expressed ligands.VEGFR-2 conformational switch in response to ligand binding.VEGF regulates local inhibitory complement proteins in the eye and kidney.Multi-scale Modeling in Clinical Oncology: Opportunities and Barriers to Success.Modulation of VEGF receptor 2 signaling by protein phosphatases.Selective Targeting of a Novel Epsin-VEGFR2 Interaction Promotes VEGF-Mediated Angiogenesis.Integrative meta-modeling identifies endocytic vesicles, late endosome and the nucleus as the cellular compartments primarily directing RTK signaling.Synthetic microparticles conjugated with VEGF165 improve the survival of endothelial progenitor cells via microRNA-17 inhibition.Further Support for ECM Control of Receptor Trafficking and Signaling.Systems Pharmacology of VEGF165b in Peripheral Artery Disease.VEGFR1 promotes cell migration and proliferation through PLCγ and PI3K pathways.Oroxyloside inhibits angiogenesis through suppressing internalization of VEGFR2/Flk-1 in endothelial cells.A computational analysis of pro-angiogenic therapies for peripheral artery disease.Molecular Pharmacology of VEGF-A Isoforms: Binding and Signalling at VEGFR2.Intranasal delivery of VEGF enhances compensatory lung growth in mice.Computer Simulation of TSP1 Inhibition of VEGF-Akt-eNOS: An Angiogenesis Triple Threat.The EphA2 receptor is activated through induction of distinct, ligand-dependent oligomeric structuresComputational modeling of synergistic interaction between αVβ3 integrin and VEGFR2 in endothelial cells: Implications for the mechanism of action of angiogenesis-modulating integrin-binding peptidesQuantifying the phosphorylation timescales of receptor-ligand complexes: a Markovian matrix-analytic approach
P2860
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P2860
Site-Specific Phosphorylation of VEGFR2 Is Mediated by Receptor Trafficking: Insights from a Computational Model
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Site-Specific Phosphorylation ...... hts from a Computational Model
@ast
Site-Specific Phosphorylation ...... hts from a Computational Model
@en
type
label
Site-Specific Phosphorylation ...... hts from a Computational Model
@ast
Site-Specific Phosphorylation ...... hts from a Computational Model
@en
prefLabel
Site-Specific Phosphorylation ...... hts from a Computational Model
@ast
Site-Specific Phosphorylation ...... hts from a Computational Model
@en
P2860
P1476
Site-Specific Phosphorylation ...... hts from a Computational Model
@en
P2093
Feilim Mac Gabhann
P2860
P304
P356
10.1371/JOURNAL.PCBI.1004158
P577
2015-06-12T00:00:00Z