Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage.
about
The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradation{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligaseMDM2 suppresses p73 function without promoting p73 degradationSmall molecule compounds targeting the p53 pathway: are we finally making progress?MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitinationMdm2: the ups and downs.Modulation of mdm2 pre-mRNA splicing by 9-aminoacridine-PNA (peptide nucleic acid) conjugates targeting intron-exon junctions.Role of Stat3 in regulating p53 expression and functionTranscription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53Strategies for manipulating the p53 pathway in the treatment of human cancer.MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells.Identification of a new class of MDM2 inhibitor that inhibits growth of orthotopic pancreatic tumors in mice.Differentiation of Hdm2-mediated p53 ubiquitination and Hdm2 autoubiquitination activity by small molecular weight inhibitors.Image cytometric analysis of p53 and mdm-2 expression in primary and recurrent mucoepidermoid carcinoma of parotid gland: immunohistochemical study.The MDM2 gene amplification databasemdm2 Is critical for inhibition of p53 during lymphopoiesis and the response to ionizing irradiation.Cytotoxic effect of a non-peptidic small molecular inhibitor of the p53-HDM2 interaction on tumor cells.Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor.Pharmacological inhibition of Mdm2 triggers growth arrest and promotes DNA breakage in mouse colon tumors and human colon cancer cellsDevelopment and validation of a rapid HPLC method for quantitation of SP-141, a novel pyrido[b]indole anticancer agent, and an initial pharmacokinetic study in mice.Antisense therapy targeting MDM2 oncogene in prostate cancer: Effects on proliferation, apoptosis, multiple gene expression, and chemotherapy.Identification of FDA-approved drugs that computationally bind to MDM2The Ubiquitin Proteasome Pathway (UPP) in the regulation of cell cycle control and DNA damage repair and its implication in tumorigenesisUbiquitous induction of p53 in tumor cells by antisense inhibition of MDM2 expression.Genetics of melanomaIdentification of lineariifolianoid A as a novel dual NFAT1 and MDM2 inhibitor for human cancer therapyNuclear exclusion of p53 in a subset of tumors requires MDM2 function.MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53.Down-regulation of MDM2 and activation of p53 in human cancer cells by antisense 9-aminoacridine-PNA (peptide nucleic acid) conjugates.Enhancement of antitumor activity of cisplatin in human lung cancer cells by tumor suppressor FUS1.Activation of an MDM2-specific caspase by p53 in the absence of apoptosis.p53 protein oxidation in cultured cells in response to pyrrolidine dithiocarbamate: a novel method for relating the amount of p53 oxidation in vivo to the regulation of p53-responsive genesp53 in the CNS: Perspectives on Development, Stem Cells, and Cancer.Activation of p53 by roscovitine-mediated suppression of MDM2 expression.Reactivation of p53 in cells expressing hepatitis B virus X-protein involves p53 phosphorylation and a reduction of Hdm2.Cytoplasmically "sequestered" wild type p53 protein is resistant to Mdm2-mediated degradation.p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53.Overexpression of MDM2 in MCF-7 promotes both growth advantage and p53 accumulation in response to estradiol.A novel MDM2 anti-sense oligonucleotide has anti-tumor activity and potentiates cytotoxic drugs acting by different mechanisms in human colon cancer.
P2860
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P2860
Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage.
@ast
Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage.
@en
type
label
Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage.
@ast
Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage.
@en
prefLabel
Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage.
@ast
Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage.
@en
P2093
P2860
P356
P1476
Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage.
@en
P2093
P2860
P304
P356
10.1073/PNAS.95.1.195
P407
P577
1998-01-01T00:00:00Z