A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2.
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Megakaryocyte pathology and bone marrow fibrosis: the lysyl oxidase connectionMPNs as Inflammatory Diseases: The Evidence, Consequences, and PerspectivesThe Hen or the Egg: Inflammatory Aspects of Murine MPN ModelsThe Role of Reactive Oxygen Species in Myelofibrosis and Related NeoplasmsErythro-megakaryocytic transcription factors associated with hereditary anemiaRegulation and function of the NFE2 transcription factor in hematopoietic and non-hematopoietic cellsCD133 marks a stem cell population that drives human primary myelofibrosis.Efficacy of vorinostat in a murine model of polycythemia veraBMP signalling differentially regulates distinct haematopoietic stem cell typesMPN patients harbor recurrent truncating mutations in transcription factor NF-E2Elevated nuclear factor erythroid-2 levels promote epo-independent erythroid maturation and recapitulate the hematopoietic stem cell and common myeloid progenitor expansion observed in polycythemia vera patients.Transcription factor nuclear factor erythroid-2 mediates expression of the cytokine interleukin 8, a known predictor of inferior outcome in patients with myeloproliferative neoplasms.Subcellular mislocalization of the transcription factor NF-E2 in erythroid cells discriminates prefibrotic primary myelofibrosis from essential thrombocythemia.A novel role for nuclear factor-erythroid 2 in erythroid maturation by modulation of mitochondrial autophagy.RUNX1 and NF-E2 upregulation is not specific for MPNs, but is seen in polycythemic disorders with augmented HIF signaling.The gep proto-oncogene Gα12 mediates LPA-stimulated activation of CREB in ovarian cancer cells.Genetic basis of MPN: Beyond JAK2-V617F.Nuclear Factor Erythroid 2 Regulates Human HSC Self-Renewal and T Cell Differentiation by Preventing NOTCH1 Activation.Myeloproliferative neoplasms and inflammation: whether to target the malignant clone or the inflammatory process or both.Investigational histone deacetylase inhibitors (HDACi) in myeloproliferative neoplasms.A phase II study of vorinostat (MK-0683) in patients with polycythaemia vera and essential thrombocythaemia.A novel biological function of soluble biglycan: Induction of erythropoietin production and polycythemia.RUNX1 cooperates with FLT3-ITD to induce leukemia.Mathematical modelling as a proof of concept for MPNs as a human inflammation model for cancer developmentJAK2 V617F stimulates proliferation of erythropoietin-dependent erythroid progenitors and delays their differentiation by activating Stat1 and other nonerythroid signaling pathways.Mutations in myeloproliferative neoplasms - their significance and clinical use.Epigenetic regulation of NFE2 overexpression in myeloproliferative neoplasms.[Differential diagnosis of myeloproliferative neoplasms. Quantitative NF-E2 immunohistochemistry for differentiating between essential thrombocythemia and primary myelofibrosis].A common molecular signature of patients with sickle cell disease revealed by microarray meta-analysis and a genome-wide association study
P2860
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P2860
A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
A novel murine model of myelop ...... he transcription factor NF-E2.
@ast
A novel murine model of myelop ...... he transcription factor NF-E2.
@en
type
label
A novel murine model of myelop ...... he transcription factor NF-E2.
@ast
A novel murine model of myelop ...... he transcription factor NF-E2.
@en
prefLabel
A novel murine model of myelop ...... he transcription factor NF-E2.
@ast
A novel murine model of myelop ...... he transcription factor NF-E2.
@en
P2093
P2860
P50
P356
P1476
A novel murine model of myelop ...... he transcription factor NF-E2.
@en
P2093
Albert Gründer
Alessandro Rambaldi
Britta Will
Doris Steinemann
Heike L Pahl
Jonas S Jutzi
Julia M Wagner
Julius Wehrle
Kai B Kaufmann
Kien-Binh Pham
P2860
P356
10.1084/JEM.20110540
P407
P577
2012-01-09T00:00:00Z