Bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2.
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Balkan endemic nephropathy: an update on its aetiologyPulmonary Inflammation Impacts on CYP1A1-Mediated Respiratory Tract DNA Damage Induced by the Carcinogenic Air Pollutant Benzo[a]pyreneMechanisms of enzyme-catalyzed reduction of two carcinogenic nitro-aromatics, 3-nitrobenzanthrone and aristolochic acid I: Experimental and theoretical approachesContributions of human enzymes in carcinogen metabolismBaicalin Protects Mice from Aristolochic Acid I-Induced Kidney Injury by Induction of CYP1A through the Aromatic Hydrocarbon Receptor.New Approaches for Biomonitoring Exposure to the Human Carcinogen Aristolochic Acid.A Mechanism of O-Demethylation of Aristolochic Acid I by Cytochromes P450 and Their Contributions to This Reaction in Human and Rat Livers: Experimental and Theoretical Approaches.Active Site Mutations as a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I Nitroreduction by Cytochromes P450 1A1, 1A2 and 1B1.Induction of cytochromes P450 1A1 and 1A2 suppresses formation of DNA adducts by carcinogenic aristolochic acid I in rats in vivoRole of hepatic cytochrome P450 enzymes in the detoxication of aristolochic acid I; effects on DNA adduct, mutation, and tumor formationCYP2E1 and NQO1 genotypes and bladder cancer risk in a Lebanese populationToxicological actions of plant-derived and anthropogenic methylenedioxyphenyl-substituted chemicals in mammals and insects.Knockout and humanized mice as suitable tools to identify enzymes metabolizing the human carcinogen aristolochic acid.Toxicogenetic profile and cancer risk in Lebanese.Naturally occurring aristolochic acid analogues and their toxicities.Aristolochic acid-induced apoptosis and G2 cell cycle arrest depends on ROS generation and MAP kinases activation.Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone.The influence of ochratoxin A on DNA adduct formation by the carcinogen aristolochic acid in rats.Comparison of the oxidation of carcinogenic aristolochic acid I and II by microsomal cytochromes P450 in vitro: experimental and theoretical approaches.DNA Adducts Formed by Aristolochic Acid Are Unique Biomarkers of Exposure and Explain the Initiation Phase of Upper Urothelial Cancer.NAT1 genotypic and phenotypic contribution to urinary bladder cancer risk: a systematic review and meta-analysis.Cytochrome b 5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b 5 /P450 reductase null (HBRN) mice.Mutagenicity and DNA adduct formation by aristolochic acid in the spleen of Big Blue® rats.ACB-PCR measurement of H-ras codon 61 CAA→CTA mutation provides an early indication of aristolochic acid I carcinogenic effect in tumor target tissues.Utilizing single- and double-transfected cell models expressing human organic anion transporter 1 and human cytochrome P450 1A2 to investigate the interactions with ingredients of herbal medicines.Funding Data from Publication Acknowledgments: Coverage, Uses, and Limitations
P2860
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P2860
Bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Bioactivation versus detoxicat ...... n cytochrome P450 1A1 and 1A2.
@ast
Bioactivation versus detoxicat ...... n cytochrome P450 1A1 and 1A2.
@en
type
label
Bioactivation versus detoxicat ...... n cytochrome P450 1A1 and 1A2.
@ast
Bioactivation versus detoxicat ...... n cytochrome P450 1A1 and 1A2.
@en
prefLabel
Bioactivation versus detoxicat ...... n cytochrome P450 1A1 and 1A2.
@ast
Bioactivation versus detoxicat ...... n cytochrome P450 1A1 and 1A2.
@en
P2093
P2860
P50
P356
P1476
Bioactivation versus detoxicat ...... an cytochrome P450 1A1 and 1A2
@en
P2093
Daniel W Nebert
Frantisek Bárta
Heinz H Schmeiser
Zhanquan Shi
P2860
P304
P356
10.1093/TOXSCI/KFR306
P577
2011-11-15T00:00:00Z