Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation - Wikidata - wikimedia - TriplyDB

Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation

Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation

http://www.wikidata.org/entity/Q35685580

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Protein tyrosine phosphatase non-receptor type 22 modulates NOD2-induced cytokine release and autophagy Molecular Mechanisms of Induction of Tolerant and Tolerogenic Intestinal Dendritic Cells in Mice The role of dendritic cells in autoimmunity The dark side of dendritic cells: development and exploitation of tolerogenic activity that favor tumor outgrowth and immune escape.Advances in kinase inhibition: treating rheumatic diseases and beyond.Dendritic cell maturation: functional specialization through signaling specificity and transcriptional programming The p38alpha mitogen-activated protein kinase limits the CNS proinflammatory cytokine response to systemic lipopolysaccharide, potentially through an IL-10 dependent mechanism Role and therapeutic value of dendritic cells in central nervous system autoimmunity.TLR2 directing PD-L2 expression inhibit T cells response in Schistosoma japonicum infection.Metabolic Control of Th17 Cell Generation and CNS Inflammation Canonical wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation.MicroRNA-22 impairs anti-tumor ability of dendritic cells by targeting p38.Cutting Edge: Dual Function of PPARγ in CD11c+ Cells Ensures Immune Tolerance in the Airways Mechanism for p38α-mediated experimental autoimmune encephalomyelitis.Regulation of TH17 cell differentiation by innate immune signals.Control of IL-17 receptor signaling and tissue inflammation by the p38α-MKP-1 signaling axis in a mouse model of multiple sclerosis p38α protein negatively regulates T helper type 2 responses by orchestrating multiple T cell receptor-associated signals.Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection Tat engagement of p38 MAP kinase and IRF7 pathways leads to activation of interferon-stimulated genes in antigen-presenting cells.The p38α MAPK regulates microglial responsiveness to diffuse traumatic brain injury.Control of T cell fates and immune tolerance by p38α signaling in mucosal CD103+ dendritic cells.Tuning of protein kinase circuitry by p38α is vital for epithelial tissue homeostasis.Tristetraprolin regulation of interleukin 23 mRNA stability prevents a spontaneous inflammatory disease Activation of p38α in T cells regulates the intestinal host defense against attaching and effacing bacterial infections Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells.Histone deacetylase sirtuin 1 deacetylates IRF1 protein and programs dendritic cells to control Th17 protein differentiation during autoimmune inflammation Sex-specific control of central nervous system autoimmunity by p38 mitogen-activated protein kinase signaling in myeloid cells.Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction Dendritic cell MST1 inhibits Th17 differentiation.The emerging role of p38 mitogen-activated protein kinase in multiple sclerosis and its models.Mitogen-activated protein kinase phosphatase 1 as an inflammatory factor and drug target.Genetic dissection of dendritic cell homeostasis and function: lessons from cell type-specific gene ablation Roles of p38α mitogen-activated protein kinase in mouse models of inflammatory diseases and cancer.Integrating p38α MAPK immune signals in nonimmune cells.The p38 mitogen-activated protein kinase cascade modulates T helper type 17 differentiation and functionality in multiple sclerosis.A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870.Pramipexole, a Dopamine D2/D3 Receptor-Preferring Agonist, Prevents Experimental Autoimmune Encephalomyelitis Development in Mice.p38α MAPK regulates adult muscle stem cell fate by restricting progenitor proliferation during postnatal growth and repair.TLR7 Engagement on Dendritic Cells Enhances Autoreactive Th17 Responses via Activation of ERK.Impaired Notch-MKP-1 signalling in hidradenitis suppurativa: an approach to pathogenesis by evidence from translational biology.

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P2860

Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation

http://www.wikidata.org/entity/Q35685580

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name

Signaling via the kinase p38α ...... on and autoimmune inflammation

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Signaling via the kinase p38α ...... on and autoimmune inflammation

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Signaling via the kinase p38α ...... on and autoimmune inflammation

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Signaling via the kinase p38α ...... on and autoimmune inflammation

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Signaling via the kinase p38α ...... on and autoimmune inflammation

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Gonghua Huang

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Kinya Otsu

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Yanyan Wang

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P2860

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo

Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling

The selectivity of protein kinase inhibitors: a further update

IL-17 and Th17 Cells

Induction of intestinal Th17 cells by segmented filamentous bacteria

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation.

Interferon-β exacerbates Th17-mediated inflammatory disease.

IL-1β-mediated signals preferentially drive conversion of regulatory T cells but not conventional T cells into IL-17-producing cells.

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10.1038/NI.2207

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2

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Thirumala-Devi Kanneganti

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221735008

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3262925

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