Use of baculovirus BacMam vectors for expression of ABC drug transporters in mammalian cells.
about
Screening compounds with a novel high-throughput ABCB1-mediated efflux assay identifies drugs with known therapeutic targets at risk for multidrug resistance interferenceMultiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1)Design and synthesis of human ABCB1 (P-glycoprotein) inhibitors by peptide coupling of diverse chemical scaffolds on carboxyl and amino termini of (S)-valine-derived thiazole amino acid.Pharmacophore modeling of nilotinib as an inhibitor of ATP-binding cassette drug transporters and BCR-ABL kinase using a three-dimensional quantitative structure-activity relationship approachConstruction of a Baculovirus vector containing A subunit of Shiga toxin for protein delivery.Revealing the fate of cell surface human P-glycoprotein (ABCB1): The lysosomal degradation pathway.Using the BacMam Baculovirus System to Study Expression and Function of Recombinant Efflux Drug Transporters in Polarized Epithelial Cell MonolayersDrug-protein hydrogen bonds govern the inhibition of the ATP hydrolysis of the multidrug transporter P-glycoproteinBaculovirus: an insect-derived vector for diverse gene transfer applicationsMutations in intracellular loops 1 and 3 lead to misfolding of human P-glycoprotein (ABCB1) that can be rescued by cyclosporine A, which reduces its association with chaperone Hsp70.Conserved Walker A cysteines 431 and 1074 in human P-glycoprotein are accessible to thiol-specific agents in the apo and ADP-vanadate trapped conformations.Design, synthesis, and biological evaluation of (S)-valine thiazole-derived cyclic and noncyclic peptidomimetic oligomers as modulators of human P-glycoprotein (ABCB1).Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity.Human-Mouse Chimeras with Normal Expression and Function Reveal That Major Domain Swapping Is Tolerated by P-Glycoprotein (ABCB1).Screening and large-scale expression of membrane proteins in mammalian cells for structural studies.Immunostaining and time-lapse analysis of vinblastine-induced paracrystal formation in human A549 cells.Global alteration of the drug-binding pocket of human P-glycoprotein (ABCB1) by substitution of fifteen conserved residues reveals a negative correlation between substrate size and transport efficiency.Mapping discontinuous epitopes for MRK-16, UIC2 and 4E3 antibodies to extracellular loops 1 and 4 of human P-glycoproteinEvidence for the critical role of transmembrane helices 1 and 7 in substrate transport by human P-glycoprotein (ABCB1)
P2860
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P2860
Use of baculovirus BacMam vectors for expression of ABC drug transporters in mammalian cells.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Use of baculovirus BacMam vect ...... ansporters in mammalian cells.
@ast
Use of baculovirus BacMam vect ...... ansporters in mammalian cells.
@en
type
label
Use of baculovirus BacMam vect ...... ansporters in mammalian cells.
@ast
Use of baculovirus BacMam vect ...... ansporters in mammalian cells.
@en
prefLabel
Use of baculovirus BacMam vect ...... ansporters in mammalian cells.
@ast
Use of baculovirus BacMam vect ...... ansporters in mammalian cells.
@en
P2093
P2860
P356
P1476
Use of baculovirus BacMam vect ...... ansporters in mammalian cells.
@en
P2093
Abdul Kouanda
Candice Schwartz
Khyati Kapoor
Suneet Shukla
Suresh V Ambudkar
P2860
P304
P356
10.1124/DMD.111.042721
P577
2011-10-31T00:00:00Z