Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models. - Wikidata - wikimedia - TriplyDB

Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models.

Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models.

http://www.wikidata.org/entity/Q35690375

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Podocytes Podocyte endocytosis in the regulation of the glomerular filtration barrier The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier.Alteration of histone H3K4 methylation in glomerular podocytes associated with proteinuria in patients with membranous nephropathy.Drug discovery in focal and segmental glomerulosclerosis Novel therapeutic approaches for chronic kidney disease due to glomerular disorders.Dissecting the genetic components of a quantitative trait locus for blood pressure and renal pathology on rat chromosome 3.Unwinding focal segmental glomerulosclerosis Protein kinase C ϵ stabilizes β-catenin and regulates its subcellular localization in podocytes.Targeting the podocyte cytoskeleton: from pathogenesis to therapy in proteinuric kidney disease.The next generation of therapeutics for chronic kidney disease Podocyte-actin dynamics in health and disease.Podocytes from the diagnostic and therapeutic point of view.Optimal management of primary focal segmental glomerulosclerosis in adults Recent Treatment Advances and New Trials in Adult Nephrotic Syndrome.HIV infection is influenced by dynamin at 3 independent points in the viral life cycle.Ultrastructural Characterization of the Glomerulopathy in Alport Mice by Helium Ion Scanning Microscopy (HIM).Drugs targeting dynamin can restore cytoskeleton and focal contact alterations of urinary podocytes derived from patients with nephrotic syndrome.Networks that link cytoskeletal regulators and diaphragm proteins underpin filtration function in Drosophila nephrocytes.The Evolving Complexity of the Podocyte Cytoskeleton.O-linked β-N-acetylglucosamine modification of proteins is essential for foot process maturation and survival in podocytes.Dynamin Autonomously Regulates Podocyte Focal Adhesion Maturation.Actin dynamics at focal adhesions: a common endpoint and putative therapeutic target for proteinuric kidney diseases.A vital role for myosin-9 in puromycin aminonucleoside-induced podocyte injury by affecting actin cytoskeleton.Molecular Mechanisms of Proteinuria in Focal Segmental Glomerulosclerosis.Nephrin Signaling in the Podocyte: An Updated View of Signal Regulation at the Slit Diaphragm and Beyond.Polymer Nanoparticle Engineering for Podocyte Repair: From in Vitro Models to New Nanotherapeutics in Kidney Diseases.Understanding Podocyte Biology to Develop Novel Kidney Therapeutics Plectin protects podocytes from adriamycin-induced apoptosis and F-actin cytoskeletal disruption through the integrin α6β4/FAK/p38 MAPK pathway

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Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models.

http://www.wikidata.org/entity/Q35690375

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Nature Medicine

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Pharmacological targeting of a ...... ease in diverse animal models.

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Aleksandr Vasilyev

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Beina Teng

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Changkyu Gu

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Changli Wei

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Chuang Chen

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Faikah Gueler

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Irini Tossidou

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Jochen Reiser

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Joon-Keun Park

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Lynne Staggs

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P2860

Mutations in the formin gene INF2 cause focal segmental glomerulosclerosis

Direct dynamin-actin interactions regulate the actin cytoskeleton.

Nephrin is specifically located at the slit diaphragm of glomerular podocytes

Alpha-actinin-4-mediated FSGS: an inherited kidney disease caused by an aggregated and rapidly degraded cytoskeletal protein

"Zebrafishing" for novel genes relevant to the glomerular filtration barrier

Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis

Regulation of dynamin oligomerization in cells: the role of dynamin-actin interactions and its GTPase activity.

Dimeric endophilin A2 stimulates assembly and GTPase activity of dynamin 2

Rapid purification of native dynamin I and colorimetric GTPase assay.

Dynamin and its role in membrane fission.

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10.1038/NM.3843

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6

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21

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Denise Hilfiker-Kleiner

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2015-05-11T00:00:00Z

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276146941

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25962121

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4458177

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