Rapid turnover of mcl-1 couples translation to cell survival and apoptosis.
about
Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependencyAltering chemosensitivity by modulating translation elongationUp-regulation of Mcl-1 and Bak by coronavirus infection of human, avian and animal cells modulates apoptosis and viral replicationActivation of the mitochondrial death pathway is commonly mediated by a preferential engagement of Bak.Phosphatidylinositol 3-kinase signaling in proliferating cells maintains an anti-apoptotic transcriptional program mediated by inhibition of FOXO and non-canonical activation of NFkappaB transcription factorsEvidence of mitochondrial dysfunction in fragile X-associated tremor/ataxia syndromeSindbis viral vector induced apoptosis requires translational inhibition and signaling through Mcl-1 and Bak.Pseudomonas exotoxin A-mediated apoptosis is Bak dependent and preceded by the degradation of Mcl-1Small interfering RNA targeting mcl-1 enhances proteasome inhibitor-induced apoptosis in various solid malignant tumorsABT-737 overcomes resistance to immunotoxin-mediated apoptosis and enhances the delivery of pseudomonas exotoxin-based proteins to the cell cytosol.The cyclin-dependent kinase inhibitor SCH 727965 (dinacliclib) induces the apoptosis of osteosarcoma cellsUtilization of the cellular stress response to sensitize cancer cells to TRAIL-mediated apoptosis.MCL1 and BCL-xL levels in solid tumors are predictive of dinaciclib-induced apoptosis.Cell metabolism: an essential link between cell growth and apoptosisOppositional regulation of Noxa by JNK1 and JNK2 during apoptosis induced by proteasomal inhibitorsNavitoclax (ABT-263) accelerates apoptosis during drug-induced mitotic arrest by antagonizing Bcl-xL.Quercetin downregulates Mcl-1 by acting on mRNA stability and protein degradation.A guide to taming a toxin--recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer.Characterization of Cholix toxin-induced apoptosis in HeLa cells.MCL-1, BCL-XL and MITF Are Diversely Employed in Adaptive Response of Melanoma Cells to Changes in Microenvironment.Antiapoptotic signaling via MCL1 confers resistance to caspase-3-mediated apoptotic cell death in the pregnant human uterine myocyte.Sorafenib inhibits STAT3 activation to enhance TRAIL-mediated apoptosis in human pancreatic cancer cellsKLF9 is a novel transcriptional regulator of bortezomib- and LBH589-induced apoptosis in multiple myeloma cells.The p53 upregulated modulator of apoptosis (PUMA) chemosensitizes intrinsically resistant ovarian cancer cells to cisplatin by lowering the threshold set by Bcl-x(L) and Mcl-1Bay 61-3606 Sensitizes TRAIL-Induced Apoptosis by Downregulating Mcl-1 in Breast Cancer Cells.Regulation of subtilase cytotoxin-induced cell death by an RNA-dependent protein kinase-like endoplasmic reticulum kinase-dependent proteasome pathway in HeLa cellsRegulation of ubiquitination-mediated protein degradation by survival kinases in cancer.Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survivalCycloheximide Can Induce Bax/Bak Dependent Myeloid Cell Death Independently of Multiple BH3-Only ProteinsDissecting eIF4E action in tumorigenesisEffective elimination of chronic lymphocytic leukemia cells in the stromal microenvironment by a novel drug combination strategy using redox-mediated mechanisms.Germline quality control: eEF2K stands guard to eliminate defective oocytesTransformation, translation and TRAIL: an unexpected intersection.Afferent regulation of chicken auditory brainstem neurons: rapid changes in phosphorylation of elongation factor 2.BCL-2 family regulation by the 20S proteasome inhibitor bortezomib.Induction of BAG2 protein during proteasome inhibitor-induced apoptosis in thyroid carcinoma cells.PI3K-dependent upregulation of Mcl-1 by human cytomegalovirus is mediated by epidermal growth factor receptor and inhibits apoptosis in short-lived monocytes.Synergistic combinations of signaling pathway inhibitors: mechanisms for improved cancer therapy.Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis.Context-dependent Bcl-2/Bak interactions regulate lymphoid cell apoptosis.
P2860
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P2860
Rapid turnover of mcl-1 couples translation to cell survival and apoptosis.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Rapid turnover of mcl-1 couples translation to cell survival and apoptosis.
@ast
Rapid turnover of mcl-1 couples translation to cell survival and apoptosis.
@en
type
label
Rapid turnover of mcl-1 couples translation to cell survival and apoptosis.
@ast
Rapid turnover of mcl-1 couples translation to cell survival and apoptosis.
@en
prefLabel
Rapid turnover of mcl-1 couples translation to cell survival and apoptosis.
@ast
Rapid turnover of mcl-1 couples translation to cell survival and apoptosis.
@en
P2860
P356
P1476
Rapid turnover of mcl-1 couples translation to cell survival and apoptosis.
@en
P2093
Geoffrey M Cooper
Kenneth W Adams
P2860
P304
P356
10.1074/JBC.M610643200
P407
P577
2007-01-02T00:00:00Z