Functional analysis of APOE locus genetic variation implicates regional enhancers in the regulation of both TOMM40 and APOE. - Wikidata - wikimedia - TriplyDB

Functional analysis of APOE locus genetic variation implicates regional enhancers in the regulation of both TOMM40 and APOE.

Functional analysis of APOE locus genetic variation implicates regional enhancers in the regulation of both TOMM40 and APOE.

http://www.wikidata.org/entity/Q35696751

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Meta-analysis of the rs2075650 polymorphism and risk of Alzheimer disease.Genes determining the severity of cerebral palsy: the role of single nucleotide polymorphisms on the amount and structure of apolipoprotein E.Gene sequences regulating the production of apoE and cerebral palsy of variable severity.ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice.Epigenetic signature and enhancer activity of the human APOE gene.TOMM40 rs2075650 may represent a new candidate gene for vulnerability to major depressive disorder.APOE ε4-TOMM40 '523 haplotypes and the risk of Alzheimer's disease in older Caucasian and African Americans The cis-regulatory effect of an Alzheimer's disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes.BACE1 levels by APOE genotype in non-demented and Alzheimer's post-mortem brains Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949).Alzheimer's disease susceptibility genes APOE and TOMM40, and hippocampal volumes in the Lothian birth cohort 1936.Atherosclerosis and Alzheimer--diseases with a common cause? Inflammation, oxysterols, vasculature The Broad Impact of TOM40 on Neurodegenerative Diseases in Aging Association of TOMM40 and SLC22A4 polymorphisms with ischemic stroke.Apolipoprotein C-I is an APOE genotype-dependent suppressor of glial activation Comprehensive search for Alzheimer disease susceptibility loci in the APOE region.TOMM40 intron 6 poly-T length, age at onset, and neuropathology of AD in individuals with APOE ε3/ε3.A Genetics-based Biomarker Risk Algorithm for Predicting Risk of Alzheimer's Disease.The Role of Upregulated APOE in Alzheimer's Disease Etiology.The influence of APOE and TOMM40 polymorphisms on hippocampal volume and episodic memory in old age Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study.The Alzheimer's disease mitochondrial cascade hypothesis: progress and perspectives.Alzheimer's disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936.Relationship between genetic risk factors and markers for Alzheimer's disease pathology.Living long and ageing well: is epigenomics the missing link between nature and nurture?The Biological Foundation of the Genetic Association of TOMM40 with Late-onset Alzheimer's disease.The effects of PPARγ on the regulation of the TOMM40-APOE-C1 genes cluster.APOE gene and neuropsychiatric disorders and endophenotypes: A comprehensive review.New Genetic Approaches to AD: Lessons from APOE-TOMM40 Phylogenetics.Coronary artery disease-associated genetic variants and biomarkers of inflammation The place of genetics in ageing research.A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing.Towards precision medicine in Alzheimer's disease: deciphering genetic data to establish informative biomarkers.FOXO3 cell resilience gene neighborhood.Neuropathologic features of TOMM40 '523 variant on late-life cognitive decline.Association of TOMM40 polymorphisms with late-onset Alzheimer's disease in a Northern Han Chinese population.Association of common variants in TOMM40/APOE/APOC1 region with human longevity in a Chinese population.The effects of the TOMM40 poly-T alleles on Alzheimer's disease phenotypes.DNA methylation in the APOE genomic region is associated with cognitive function in African Americans.

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Functional analysis of APOE locus genetic variation implicates regional enhancers in the regulation of both TOMM40 and APOE.

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Functional analysis of APOE lo ...... ation of both TOMM40 and APOE.

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Functional analysis of APOE lo ...... ation of both TOMM40 and APOE.

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Functional analysis of APOE lo ...... ation of both TOMM40 and APOE.

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Functional analysis of APOE lo ...... ation of both TOMM40 and APOE.

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Functional analysis of APOE lo ...... ation of both TOMM40 and APOE.

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Journal of Human Genetics

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Functional analysis of APOE lo ...... ation of both TOMM40 and APOE.

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Chang-En Yu

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Franziska Lutz

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Lynn M Bekris

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P2860

Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease

Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease

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Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

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The human genome browser at UCSC

Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: patterns of linkage disequilibrium and disease/marker association.

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Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta

Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort

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