A historical overview of protein kinases and their targeted small molecule inhibitors.
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Counteracting Protein Kinase Activity in the Heart: The Multiple Roles of Protein PhosphatasesUnraveling the Anticancer Effect of Curcumin and ResveratrolFAM83 proteins: Fostering new interactions to drive oncogenic signaling and therapeutic resistanceThe challenges of tumor genetic diversity.Photooxygenation of an amino-thienopyridone yields a more potent PTP4A3 inhibitor.Molecular dynamics simulations and modelling of the residue interaction networks in the BRAF kinase complexes with small molecule inhibitors: probing the allosteric effects of ligand-induced kinase dimerization and paradoxical activation.Exploring Molecular Mechanisms of Paradoxical Activation in the BRAF Kinase Dimers: Atomistic Simulations of Conformational Dynamics and Modeling of Allosteric Communication Networks and Signaling Pathways.Site-specific His/Asp phosphoproteomic analysis of prokaryotes reveals putative targets for drug resistance.Harnessing protein kinase A activation to induce mesenchymal-epithelial programs to eliminate chemoresistant, tumor-initiating breast cancer cellsAntitumor/Antifungal Celecoxib Derivative AR-12 is a Non-Nucleoside Inhibitor of the ANL-Family Adenylating Enzyme Acetyl CoA Synthetase.Antiproliferative effects of masitinib and imatinib against canine oral fibrosarcoma in vitroSequence- and Structure-Based Analysis of Tissue-Specific Phosphorylation SitesDNA Repair--A Double-Edged Sword in the Genomic Stability of Cancer Cells--The Case of Chronic Myeloid Leukemia.Targeting protein kinases to reverse multidrug resistance in sarcoma.A novel protein kinase is essential in bloodstream Trypanosoma bruceiUnidirectional allostery in the regulatory subunit RIα facilitates efficient deactivation of protein kinase A.Reduced Activity of Mutant Calcium-Dependent Protein Kinase 1 Is Compensated in Plasmodium falciparum through the Action of Protein Kinase G.RRD-251 enhances all-trans retinoic acid (RA)-induced differentiation of HL-60 myeloblastic leukemia cells.E6-Associated Protein Dependent Estrogen Receptor Regulation of Protein Kinase A Regulatory Subunit R2A Expression in Neuroblastoma.Sex-Divergent Clinical Outcomes and Precision Medicine: An Important New Role for Institutional Review Boards and Research Ethics Committees.Progress towards a public chemogenomic set for protein kinases and a call for contributions.Design, synthesis, and biological evaluation of pyrimidine derivatives as potential inhibitors of human calcium/calmodulin-dependent protein kinase IV.Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015).Monocarboxylate transporter 1 contributes to growth factor-induced tumor cell migration independent of transporter activity.Effects of Different Cell-Detaching Methods on the Viability and Cell Surface Antigen Expression of Synovial Mesenchymal Stem Cells.Identification of cellular targets involved in cardiac failure caused by PKI in oncology: an approach combining pharmacovigilance and pharmacodynamics.Novel protein kinase targets in vascular smooth muscle therapeutics.Targeting Tyrosine Phosphatases: Time to End the Stigma.Applications of Nonenzymatic Catalysts to the Alteration of Natural Products.Phosphoryl Group Flow within the Pseudomonas aeruginosa Pil-Chp Chemosensory System: DIFFERENTIAL FUNCTION OF THE EIGHT PHOSPHOTRANSFERASE AND THREE RECEIVER DOMAINS.Protein tyrosine phosphatase PTPRB regulates Src phosphorylation and tumour progression in NSCLC.Anti-hepatocellular carcinoma properties of the anti-alcoholism drug disulfiram discovered to enzymatically inhibit the AMPK-related kinase SNARK in vitro.A Pyrazolo[3,4-d]pyrimidine Compound Reduces Cell Viability and Induces Apoptosis in Different Hematological Malignancies.Characterizing the Hot Spots Involved in RON-MSPβ Complex Formation Using In Silico Alanine Scanning Mutagenesis and Molecular Dynamics Simulation.Corrigendum: Discoidin Domain Receptors: Potential Actors and Targets in Cancer.Recombinant Immunotoxin 4D5scFv-PE40 for Targeted Therapy of HER2-Positive TumorsEnsemble-based modeling and rigidity decomposition of allosteric interaction networks and communication pathways in cyclin-dependent kinases: Differentiating kinase clients of the Hsp90-Cdc37 chaperone.Longitudinal Transcriptional Response of Glycosylation-Related Genes, Regulators, and Targets in Cancer Cell Lines Treated With 11 Antitumor Agents.Role of drug-dependent transporter modulation on the chemosensitivity of cholangiocarcinoma.Insights into the Impact of Linker Flexibility and Fragment Ionization on the Design of CK2 Allosteric Inhibitors: Comparative Molecular Dynamics Simulation Studies.
P2860
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P2860
A historical overview of protein kinases and their targeted small molecule inhibitors.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
A historical overview of protein kinases and their targeted small molecule inhibitors.
@ast
A historical overview of protein kinases and their targeted small molecule inhibitors.
@en
type
label
A historical overview of protein kinases and their targeted small molecule inhibitors.
@ast
A historical overview of protein kinases and their targeted small molecule inhibitors.
@en
prefLabel
A historical overview of protein kinases and their targeted small molecule inhibitors.
@ast
A historical overview of protein kinases and their targeted small molecule inhibitors.
@en
P1476
A historical overview of protein kinases and their targeted small molecule inhibitors.
@en
P356
10.1016/J.PHRS.2015.07.010
P577
2015-07-21T00:00:00Z