AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation. - Wikidata - wikimedia - TriplyDB

AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation.

AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation.

http://www.wikidata.org/entity/Q35742842

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The AMPK agonist AICAR inhibits TGF-β1 induced activation of kidney myofibroblasts Divergent Activity Profiles of Type 1 Ryanodine Receptor Channels Carrying Malignant Hyperthermia and Central Core Disease Mutations in the Amino-Terminal Region Lipopolysaccharide-induced loss of cultured rat myenteric neurons - role of AMP-activated protein kinase An ancient riboswitch class in bacteria regulates purine biosynthesis and one-carbon metabolism Parallel universes of Black Six biology.Ligands for FKBP12 increase Ca2+ influx and protein synthesis to improve skeletal muscle function.Small heat-shock proteins protect from heat-stroke-associated neurodegeneration.Allele-specific gene silencing in two mouse models of autosomal dominant skeletal myopathy.Malignant hyperthermia and the clinical significance of type-1 ryanodine receptor gene (RYR1) variants: proceedings of the 2013 MHAUS Scientific Conference.Patterns of gene expression associated with recovery and injury in heat-stressed rats.Metabolomics Analysis Reveals that AICAR Affects Glycerolipid, Ceramide and Nucleotide Synthesis Pathways in INS-1 Cells.Oxidative stress, mitochondrial damage, and cores in muscle from calsequestrin-1 knockout mice Antioxidants protect calsequestrin-1 knockout mice from halothane- and heat-induced sudden death.Nitrosative modifications of the Ca2+ release complex and actin underlie arthritis-induced muscle weakness.Ryanodine receptor fragmentation and sarcoplasmic reticulum Ca2+ leak after one session of high-intensity interval exercise.The AMPK-PPARGC1A pathway is required for antimicrobial host defense through activation of autophagy.A chemical chaperone improves muscle function in mice with a RyR1 mutation.5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-Monophosphate (AICAR), a Highly Conserved Purine Intermediate with Multiple Effects.The disorders of the calcium release unit of skeletal muscles: what have we learned from mouse models?Calcium at the Center of Cell Signaling: Interplay between Endoplasmic Reticulum, Mitochondria, and Lysosomes.5-Aminoimidazole-4-carboxamide ribonucleoside induces differentiation of acute myeloid leukemia cells.AICAR inhibits oxygen consumption by intact skeletal muscle cells in culture.Genotype-Phenotype Correlations of Malignant Hyperthermia and Central Core Disease Mutations in the Central Region of the RYR1 Channel.5-Aminoimidazole-4-carboxamide ribonucleoside-mediated adenosine monophosphate-activated protein kinase activation induces protective innate responses in bacterial endophthalmitis.Muscle Weakness in Rheumatoid Arthritis: The Role of Ca2+ and Free Radical Signaling.Synthesis of new acadesine (AICA-riboside) analogues having acyclic D-ribityl or 4-hydroxybutyl chains in place of the ribose.Mice with RyR1 mutation (Y524S) undergo hypermetabolic response to simvastatin.Heat shock response and ionstasis: axis against neurodegeneration.Altered Ca2+ concentration, permeability and buffering in the myofibre Ca2+ store of a mouse model of malignant hyperthermia.Combined Strategies for Maintaining Skeletal Muscle Mass and Function in Aging: Myostatin Inactivation and AICAR-Associated Oxidative Metabolism Induction.Reactive oxygen/nitrogen species and contractile function in skeletal muscle during fatigue and recovery.Effect of AMPK signal pathway on pathogenesis of abdominal aortic aneurysms.Very Low Volume High-Intensity Interval Exercise Is More Effective in Young Than Old Women.Exercise-induced rhabdomyolysis and stress-induced malignant hyperthermia events, association with malignant hyperthermia susceptibility, and RYR1 gene sequence variations A facile synthesis of 5'-fluoro-5'-deoxyacadesine (5'-F-AICAR): a novel non-phosphorylable AICAR analogue.

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AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation.

http://www.wikidata.org/entity/Q35742842

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AICAR prevents heat-induced su ...... ndependent of AMPK activation.

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AICAR prevents heat-induced su ...... ndependent of AMPK activation.

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AICAR prevents heat-induced su ...... ndependent of AMPK activation.

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AICAR prevents heat-induced su ...... ndependent of AMPK activation.

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AICAR prevents heat-induced su ...... ndependent of AMPK activation.

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AICAR prevents heat-induced su ...... ndependent of AMPK activation.

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AICAR prevents heat-induced su ...... ndependent of AMPK activation.

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Adan Dagnino-Acosta

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Aditya D Joshi

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Alina Ainbinder

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Arturo Santillan

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Chang Seok Lee

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Dimitra K Georgiou

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George G Rodney

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Iskander I Ismailov

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Johanna T Lanner

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Joshua M Oakes

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P2860

Malignant hyperthermia

AMPK and PPARdelta agonists are exercise mimetics

A new generation of Ca2+ indicators with greatly improved fluorescence properties

Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise

5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?

Mitochondrial superoxide flashes: metabolic biomarkers of skeletal muscle activity and disease

Identification of cysteines involved in S-nitrosylation, S-glutathionylation, and oxidation to disulfides in ryanodine receptor type 1.

Characterization and temporal development of cores in a mouse model of malignant hyperthermia

Genetics and pathogenesis of malignant hyperthermia.

Chronic activation of 5'-AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscle.

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10.1038/NM.2598

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2

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1044517629

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3274651

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