The projection analysis of NMR chemical shifts reveals extended EPAC autoinhibition determinants.
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Structural Analyses of a Constitutively Active Mutant of Exchange Protein Directly Activated by cAMPA Mechanism for the Auto-inhibition of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Opening and Its Relief by cAMPLigand Binding Enhances Millisecond Conformational Exchange in Xylanase B2 from Streptomyces lividansThe auto-inhibitory role of the EPAC hinge helix as mapped by NMRAllosteric coupling between the intracellular coupling helix 4 and regulatory sites of the first nucleotide-binding domain of CFTRExchange protein directly activated by cAMP encoded by the mammalian rapgef3 gene: Structure, function and therapeuticsNMR Characterization of Information Flow and Allosteric Communities in the MAP Kinase p38γRecent advances in the discovery of small molecules targeting exchange proteins directly activated by cAMP (EPAC).Urea-Dependent Adenylate Kinase Activation following Redistribution of Structural States.NMR mapping of protein conformational landscapes using coordinated behavior of chemical shifts upon ligand binding.The future of EPAC-targeted therapies: agonism versus antagonismBiochemical and pharmacological characterizations of ESI-09 based EPAC inhibitors: defining the ESI-09 "therapeutic window".Network of long-range concerted chemical shift displacements upon ligand binding to human angiogenin.Mapping the Hydrogen Bond Networks in the Catalytic Subunit of Protein Kinase A Using H/D Fractionation FactorsMapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIα.Structure-Activity Relationship Studies of Substituted 2-(Isoxazol-3-yl)-2-oxo-N'-phenyl-acetohydrazonoyl Cyanide Analogues: Identification of Potent Exchange Proteins Directly Activated by cAMP (EPAC) Antagonists.Functionalized N,N-Diphenylamines as Potent and Selective EPAC2 Inhibitors.Unidirectional allostery in the regulatory subunit RIα facilitates efficient deactivation of protein kinase A.Allosteric linkers in cAMP signalling.Tapping the translation potential of cAMP signalling: molecular basis for selectivity in cAMP agonism and antagonism as revealed by NMR.Calcium-Independent Activation of an Allosteric Network in Langerin by Heparin Oligosaccharides.Uncoupling Catalytic and Binding Functions in the Cyclic AMP-Dependent Protein Kinase AProtein dynamics and function from solution state NMR spectroscopy.Applications of NMR and computational methodologies to study protein dynamics.Role of Dynamics in the Autoinhibition and Activation of the Hyperpolarization-activated Cyclic Nucleotide-modulated (HCN) Ion Channels.A tool set to map allosteric networks through the NMR chemical shift covariance analysis.Mechanism of cAMP Partial Agonism in Protein Kinase G (PKG).Free energy landscape remodeling of the cardiac pacemaker channel explains the molecular basis of familial sinus bradycardiaImplementation of the NMR CHEmical Shift Covariance Analysis (CHESCA): A Chemical Biologist's Approach to Allostery.Regulation of HCN Ion Channels by Non-canonical Cyclic Nucleotides.Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.Ligand-Induced Variations in Structural and Dynamical Properties Within an Enzyme Superfamily.Hydrophobic alkyl chains substituted to the 8-position of cyclic nucleotides enhance activation of CNG and HCN channels by an intricate enthalpy - entropy compensationDynamic Allostery in PLCγ1 and Its Modulation by a Cancer Mutation Revealed by MD Simulation and NMRMechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2I260Q DNA polymerase β highlights precatalytic conformational rearrangements critical for fidelity
P2860
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P2860
The projection analysis of NMR chemical shifts reveals extended EPAC autoinhibition determinants.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
The projection analysis of NMR ...... C autoinhibition determinants.
@ast
The projection analysis of NMR ...... C autoinhibition determinants.
@en
type
label
The projection analysis of NMR ...... C autoinhibition determinants.
@ast
The projection analysis of NMR ...... C autoinhibition determinants.
@en
prefLabel
The projection analysis of NMR ...... C autoinhibition determinants.
@ast
The projection analysis of NMR ...... C autoinhibition determinants.
@en
P2860
P50
P1433
P1476
The projection analysis of NMR ...... AC autoinhibition determinants
@en
P2093
Bryan VanSchouwen
Giuseppe Melacini
P2860
P304
P356
10.1016/J.BPJ.2011.12.030
P407
P577
2012-02-07T00:00:00Z