Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4.

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Recent Progress in the Molecular Recognition and Therapeutic Importance of Interleukin-1 Receptor-Associated Kinase 4 Selective interleukin-1 receptor-associated kinase 4 inhibitors for the treatment of autoimmune disorders and lymphoid malignancy.Crystal structure of human IRAK1.

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P2860

Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4.

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2015 nî lūn-bûn

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2015年の論文

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Discovery of 5-Amino-N-(1H-pyr ...... rboxamide Inhibitors of IRAK4.

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Discovery of 5-Amino-N-(1H-pyr ...... rboxamide Inhibitors of IRAK4.

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Discovery of 5-Amino-N-(1H-pyr ...... rboxamide Inhibitors of IRAK4.

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Discovery of 5-Amino-N-(1H-pyr ...... rboxamide Inhibitors of IRAK4.

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Discovery of 5-Amino-N-(1H-pyr ...... rboxamide Inhibitors of IRAK4.

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Discovery of 5-Amino-N-(1H-pyr ...... rboxamide Inhibitors of IRAK4.

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P1476

Discovery of 5-Amino-N-(1H-pyr ...... arboxamide Inhibitors of IRAK4

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P2093

Charles Lesburg

http://www.w3.org/2001/XMLSchema#string

Craig Gibeau

http://www.w3.org/2001/XMLSchema#string

Dietrich Steinhuebel

http://www.w3.org/2001/XMLSchema#string

Erica Leccese

http://www.w3.org/2001/XMLSchema#string

Erin F Mulrooney

http://www.w3.org/2001/XMLSchema#string

Hongmin Chen

http://www.w3.org/2001/XMLSchema#string

James Baker

http://www.w3.org/2001/XMLSchema#string

Jason D Brubaker

http://www.w3.org/2001/XMLSchema#string

Jeremy Presland

http://www.w3.org/2001/XMLSchema#string

Jongwon Lim

http://www.w3.org/2001/XMLSchema#string

P2860

IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase

Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper

Cutting Edge: IL-1 receptor-associated kinase 4 structures reveal novel features and multiple conformations

IRAK-4 inhibitors. Part II: a structure-based assessment of imidazo[1,2-a]pyridine binding

Pyogenic bacterial infections in humans with IRAK-4 deficiency

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

Recent advances in the discovery of small molecule inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4) as a therapeutic target for inflammation and oncology disorders

IRAK-4 inhibitors for inflammation

IRAK-4 as the central TIR signaling mediator in innate immunity

Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4.

P304

683-688

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scholarly article

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10.1021/ACSMEDCHEMLETT.5B00107

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P478

http://www.w3.org/2001/XMLSchema#string

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John Maclean

G F. Smith

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2015-04-20T00:00:00Z

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276139709

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26101574

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4468400

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Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4.

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P2860

P2860

Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4.

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