Development of cancer cachexia-like syndrome and adrenal tumors in inhibin-deficient mice
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Identification of a functional binding site for activin on the type I receptor ALK4T-cell factor 4N (TCF-4N), a novel isoform of mouse TCF-4, synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic factor 1 transcription factorsHeart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryosFollistatin overexpression in rodent liver tumors: a possible mechanism to overcome activin growth controlNeurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient miceSmad1-Smad5 ovarian conditional knockout mice develop a disease profile similar to the juvenile form of human granulosa cell tumors.A Key Role for Inhibins in Dendritic Cell Maturation and Function.Inhibins tune the thymocyte selection process by regulating thymic stromal cell differentiationGDF9 modulates the reproductive and tumor phenotype of female inha-null mice.Granulosa cell-expressed BMPR1A and BMPR1B have unique functions in regulating fertility but act redundantly to suppress ovarian tumor development.Loss of inhibin alpha uncouples oocyte-granulosa cell dynamics and disrupts postnatal folliculogenesis.Absence of inhibin alpha and retinoblastoma protein leads to early sertoli cell dysfunctionLuteinizing hormone promotes gonadal tumorigenesis in inhibin-deficient miceActivin A more prominently regulates muscle mass in primates than does GDF8.Inhibin-A antagonizes TGFbeta2 signaling by down-regulating cell surface expression of the TGFbeta coreceptor betaglycan.The ovary: basic biology and clinical implicationsActivin-A signaling promotes epithelial-mesenchymal transition, invasion, and metastatic growth of breast cancerActivin betaC and betaE genes are not essential for mouse liver growth, differentiation, and regeneration.Genetic evidence that SMAD2 is not required for gonadal tumor development in inhibin-deficient miceInhibin alpha-subunit (INHA) expression in adrenocortical cancer is linked to genetic and epigenetic INHA promoter variation.Defective gonadotropin-dependent ovarian folliculogenesis and granulosa cell gene expression in inhibin-deficient mice.Roles for transforming growth factor beta superfamily proteins in early folliculogenesis.Inhibin at 90: from discovery to clinical application, a historical reviewInhibin/activin expression in human and rodent liver: subunits α and βB as new players in human hepatocellular carcinoma?Activin induces x-zone apoptosis that inhibits luteinizing hormone-dependent adrenocortical tumor formation in inhibin-deficient mice.Of mice and models: improved animal models for biomedical research.TP53-Associated Pediatric Malignancies.Treating cancer cachexia to treat cancerThe Local Control of the Pituitary by Activin Signaling and Modulation.FSTL3 deletion reveals roles for TGF-beta family ligands in glucose and fat homeostasis in adults.TGF-β Blockade Reduces Mortality and Metabolic Changes in a Validated Murine Model of Pancreatic Cancer CachexiaTowards an understanding of the role of p53 in adrenocortical carcinogenesis.The activin A antagonist follistatin inhibits cystic fibrosis-like lung inflammation and pathology.New insights into ovarian function.Cell-type specific modulation of pituitary cells by activin, inhibin and follistatin.Activin A is a critical component of the inflammatory response, and its binding protein, follistatin, reduces mortality in endotoxemia.Adrenocortical stem and progenitor cells: unifying model of two proposed origins.Integrated stress response is critical for gemcitabine resistance in pancreatic ductal adenocarcinomaVirtual High-Throughput Screening To Identify Novel Activin Antagonists.Regulation of the adrenocortical stem cell niche: implications for disease
P2860
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P2860
Development of cancer cachexia-like syndrome and adrenal tumors in inhibin-deficient mice
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Development of cancer cachexia-like syndrome and adrenal tumors in inhibin-deficient mice
@ast
Development of cancer cachexia-like syndrome and adrenal tumors in inhibin-deficient mice
@en
type
label
Development of cancer cachexia-like syndrome and adrenal tumors in inhibin-deficient mice
@ast
Development of cancer cachexia-like syndrome and adrenal tumors in inhibin-deficient mice
@en
prefLabel
Development of cancer cachexia-like syndrome and adrenal tumors in inhibin-deficient mice
@ast
Development of cancer cachexia-like syndrome and adrenal tumors in inhibin-deficient mice
@en
P2093
P2860
P356
P1476
Development of cancer cachexia-like syndrome and adrenal tumors in inhibin-deficient mice
@en
P2093
P2860
P304
P356
10.1073/PNAS.91.19.8817
P407
P577
1994-09-01T00:00:00Z