Structure-activity relationships of cyanoquinolines with corrector-potentiator activity in ΔF508 cystic fibrosis transmembrane conductance regulator protein
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Potentiation of ΔF508- and G551D-CFTR-Mediated Cl- Current by Novel HydroxypyrazolinesEnhancing the Potency of F508del Correction: A Multi-Layer Combinational Approach to Drug Discovery for Cystic Fibrosis.Davis-Beirut reaction: route to thiazolo-, thiazino-, and thiazepino-2H-indazoles.F508del-cystic fibrosis transmembrane regulator correctors for treatment of cystic fibrosis: a patent review.Correctors of ΔF508 CFTR restore global conformational maturation without thermally stabilizing the mutant protein.Functional Rescue of F508del-CFTR Using Small Molecule CorrectorsRepairing mutated proteins--development of small molecules targeting defects in the cystic fibrosis transmembrane conductance regulator.Trimethylangelicin promotes the functional rescue of mutant F508del CFTR protein in cystic fibrosis airway cells.Efficacy and safety of liposomal clarithromycin and its effect on Pseudomonas aeruginosa virulence factors.Rescuing ΔF508 CFTR with trimethylangelicin, a dual-acting corrector and potentiator.The influence of intramolecular sulfur-lone pair interactions on small-molecule drug design and receptor binding.Partial rescue of F508del-CFTR channel gating with modest improvement of protein processing, but not stability by a dual-acting small molecule.Molecular basis of cystic fibrosis: from bench to bedside
P2860
Q28550065-A743C000-21AB-4844-8850-E168FAC09364Q33632575-26F8149E-6204-464B-A081-1411104CBFA1Q33998747-723DBDD0-F851-4A8D-AEB0-C50D8E53343AQ35630919-D959B5A4-0FB0-44C2-BEA5-3B5A67B74283Q36534393-EEA0EE21-004C-40A5-A29F-F178F4A4E3F7Q38051325-EEF78282-06E2-4DD1-B084-C4659566E0EEQ38097952-EFDB690A-7E85-46E1-AC54-BD14B4B91587Q38996193-D5406FFC-B0B8-4076-826B-A894B223063DQ39172960-36EB6F46-252E-4345-A953-EDE4F0FD2B52Q44455766-E5F91A72-1348-4CA7-9B7C-0BE097381933Q46091880-476D0F6E-B0CD-4CB2-B6D4-1FA107349EA8Q47214928-B0F1D611-35E4-4224-B6F4-866031B4470AQ57300566-19579CE2-8ADE-42ED-B6AC-EC6CE73BFE5B
P2860
Structure-activity relationships of cyanoquinolines with corrector-potentiator activity in ΔF508 cystic fibrosis transmembrane conductance regulator protein
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Structure-activity relationshi ...... conductance regulator protein
@ast
Structure-activity relationshi ...... conductance regulator protein
@en
type
label
Structure-activity relationshi ...... conductance regulator protein
@ast
Structure-activity relationshi ...... conductance regulator protein
@en
prefLabel
Structure-activity relationshi ...... conductance regulator protein
@ast
Structure-activity relationshi ...... conductance regulator protein
@en
P2093
P2860
P356
P1476
Structure-activity relationshi ...... conductance regulator protein
@en
P2093
A S Verkman
Alex B Wood
Dean J Tantillo
John M Knapp
Mark J Kurth
Michael W Lodewyk
Puay-Wah Phuan
P2860
P304
P356
10.1021/JM201372Q
P407
P577
2012-01-23T00:00:00Z