Site-directed mutagenesis of hepatocyte nuclear factor (HNF) binding sites in the mouse transthyretin (TTR) promoter reveal synergistic interactions with its enhancer region.
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Intestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4Analysis of hepatocyte nuclear factor-3 beta protein domains required for transcriptional activation and nuclear targetingTranscriptional Enhancers in the Regulation of T Cell DifferentiationFoxA proteins regulate H19 endoderm enhancer E1 and exhibit developmental changes in enhancer binding in vivoIdentification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain familyHepatocyte nuclear factor-4α interacts with other hepatocyte nuclear factors in regulating transthyretin gene expressionThe promoter for intestinal cell kinase is head-to-head with F-Box 9 and contains functional sites for TCF7L2 and FOXA factorsApplication of experimentally verified transcription factor binding sites models for computational analysis of ChIP-Seq data.Identification of interacting transcription factors regulating tissue gene expression in humanSustained Inhibition of HBV Replication In Vivo after Systemic Injection of AAVs Encoding Artificial Antiviral Primary MicroRNAs.The systemic amyloid precursor transthyretin (TTR) behaves as a neuronal stress protein regulated by HSF1 in SH-SY5Y human neuroblastoma cells and APP23 Alzheimer's disease model mice.Tissue-specific activation of mitogen-activated protein kinases for expression of transthyretin by phenylalanine and its metabolite, phenylpyruvic acid.Inhibition of hepatitis B virus replication by helper dependent adenoviral vectors expressing artificial anti-HBV pri-miRs from a liver-specific promoter.Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding.Transcription factors in mouse lung development and function.FOXA1 as a therapeutic target for breast cancer.Different DNA contact schemes are used by two winged helix proteins to recognize a DNA binding sequence.A compilation of composite regulatory elements affecting gene transcription in vertebratesGenetic variation of the transthyretin gene in wild-type transthyretin amyloidosis (ATTRwt).Improved Hepatocyte Engraftment After Portal Vein Occlusion in LDL Receptor-Deficient WHHL Rabbits and Lentiviral-Mediated Phenotypic Correction In VitroDecreased expression of hepatocyte nuclear factor 3 alpha during the acute-phase response influences transthyretin gene transcription.Modulation of hepatocyte nuclear factor-4alpha function by the peroxisome-proliferator-activated receptor-gamma co-activator-1alpha in the acute-phase response.Overproduction of a truncated hepatocyte nuclear factor 3 protein inhibits expression of liver-specific genes in hepatoma cells.The transcriptional activator hepatocyte nuclear factor 6 regulates liver gene expression.Hepatocyte nuclear factor 3 beta contains two transcriptional activation domains, one of which is novel and conserved with the Drosophila fork head proteinCis-regulatory modules in the mammalian liver: composition depends on strength of Foxa2 consensus site.The restricted promoter activity of the liver transcription factor hepatocyte nuclear factor 3 beta involves a cell-specific factor and positive autoactivationGlobal analysis of in vivo Foxa2-binding sites in mouse adult liver using massively parallel sequencingHepcidin and Hfe in iron overload in beta-thalassemia.Decreased clearance of serum retinol-binding protein and elevated levels of transthyretin in insulin-resistant ob/ob mice.Functional dissection of the brain-specific rat aldolase C gene promoter in transgenic mice. Essential role of two GC-rich boxes and an HNF3 binding site.Atypical mouse cerebellar development is caused by ectopic expression of the forkhead box transcription factor HNF-3beta.Expression of hepatocyte nuclear factor-3alpha in rat prostate, seminal vesicle, and bladder.Anti-fibrotic effect of chorionic plate-derived mesenchymal stem cells isolated from human placenta in a rat model of CCl(4)-injured liver: potential application to the treatment of hepatic diseases.Development of a Sleeping Beauty-based telomerase gene delivery system for hepatocytes.E1A represses apolipoprotein AI enhancer activity in liver cells through a pRb- and CBP-independent pathway.The HNF1/HNF4-dependent We2 element of woodchuck hepatitis virus controls viral replication and can activate the N-myc2 promoter.Activity of the rat liver-specific aldolase B promoter is restrained by HNF3.Transcriptional regulation of the apolipoprotein A-IV gene involves synergism between a proximal orphan receptor response element and a distant enhancer located in the upstream promoter region of the apolipoprotein C-III gene.Liver-specific expression of interferon gamma following adenoviral gene transfer controls hepatitis B virus replication in mice.
P2860
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P2860
Site-directed mutagenesis of hepatocyte nuclear factor (HNF) binding sites in the mouse transthyretin (TTR) promoter reveal synergistic interactions with its enhancer region.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
Site-directed mutagenesis of h ...... ions with its enhancer region.
@ast
Site-directed mutagenesis of h ...... ions with its enhancer region.
@en
type
label
Site-directed mutagenesis of h ...... ions with its enhancer region.
@ast
Site-directed mutagenesis of h ...... ions with its enhancer region.
@en
prefLabel
Site-directed mutagenesis of h ...... ions with its enhancer region.
@ast
Site-directed mutagenesis of h ...... ions with its enhancer region.
@en
P2860
P356
P1476
Site-directed mutagenesis of h ...... ions with its enhancer region.
@en
P2093
D R Grayson
P2860
Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis
Interaction of a liver-specific nuclear factor with the fibrinogen and alpha 1-antitrypsin promoters
P304
P356
10.1093/NAR/19.15.4139
P407
P577
1991-08-01T00:00:00Z