Skewed primary Igκ repertoire and V-J joining in C57BL/6 mice: implications for recombination accessibility and receptor editing.
about
Primary immunoglobulin repertoire development: time and space matterSubnuclear cyclin D3 compartments and the coordinated regulation of proliferation and immunoglobulin variable gene repressionYY1 controls Igκ repertoire and B-cell development, and localizes with condensin on the Igκ locusPractical guidelines for B-cell receptor repertoire sequencing analysisSLAP deficiency decreases dsDNA autoantibody productionThe promise and challenge of high-throughput sequencing of the antibody repertoire.A major deletion in the Vκ-Jκ intervening region results in hyperelevated transcription of proximal Vκ genes and a severely restricted repertoire.Multiple factors influence the contribution of individual immunoglobulin light chain genes to the naïve antibody repertoirePre-B cell receptor signaling induces immunoglobulin κ locus accessibility by functional redistribution of enhancer-mediated chromatin interactions.Biased Immunoglobulin Light Chain Gene Usage in the Shark.HIV-1 VACCINES. Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen.Vκ gene repertoire and locus contraction are specified by critical DNase I hypersensitive sites within the Vκ-Jκ intervening region.Complex Antigens Drive Permissive Clonal Selection in Germinal Centers.Selection of therapeutic H5N1 monoclonal antibodies following IgVH repertoire analysis in mice.Unifying model for molecular determinants of the preselection Vβ repertoire.Functionally responsive self-reactive B cells of low affinity express reduced levels of surface IgM.PU.1 Regulates Ig Light Chain Transcription and Rearrangement in Pre-B Cells during B Cell Development.Mechanisms of central tolerance for B cells.Local Chromatin Features Including PU.1 and IKAROS Binding and H3K4 Methylation Shape the Repertoire of Immunoglobulin Kappa Genes Chosen for V(D)J Recombination.Validation of Methods to Assess the Immunoglobulin Gene Repertoire in Tissues Obtained from Mice on the International Space Station.On being the right size: antibody repertoire formation in the mouse and human.Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens.Characterization of the naive murine antibody repertoire using unamplified high-throughput sequencing.Two Distinct Pathways in Mice Generate Antinuclear Antigen-Reactive B Cell Repertoires.Sequencing and cloning of antigen-specific antibodies from mouse memory B cells.Epigenetic Enhancer Marks and Transcription Factor Binding Influence Vκ Gene Rearrangement in Pre-B Cells and Pro-B CellsImmunoglobulin Light Chain Gene Rearrangements, Receptor Editing and the Development of a Self-Tolerant Antibody Repertoire
P2860
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P2860
Skewed primary Igκ repertoire and V-J joining in C57BL/6 mice: implications for recombination accessibility and receptor editing.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Skewed primary Igκ repertoire ...... sibility and receptor editing.
@ast
Skewed primary Igκ repertoire ...... sibility and receptor editing.
@en
type
label
Skewed primary Igκ repertoire ...... sibility and receptor editing.
@ast
Skewed primary Igκ repertoire ...... sibility and receptor editing.
@en
prefLabel
Skewed primary Igκ repertoire ...... sibility and receptor editing.
@ast
Skewed primary Igκ repertoire ...... sibility and receptor editing.
@en
P2093
P2860
P356
P1476
Skewed primary Igκ repertoire ...... ssibility and receptor editing
@en
P2093
Ali Torkamani
Miyo Aoki-Ota
Nicholas Schork
Takayuki Ota
P2860
P304
P356
10.4049/JIMMUNOL.1103484
P407
P50
P577
2012-01-27T00:00:00Z