Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses. - Wikidata - wikimedia - TriplyDB

Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses.

Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses.

http://www.wikidata.org/entity/Q35785139

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Mutations within the conserved NS1 nuclear export signal lead to inhibition of influenza A virus replication Binding of cellular p32 protein to the rubella virus P150 replicase protein via PxxPxR motifs Structure homology and interaction redundancy for discovering virus-host protein interactions Rotavirus nonstructural protein 1 suppresses virus-induced cellular apoptosis to facilitate viral growth by activating the cell survival pathways during early stages of infection Nonvirion protein of novirhabdovirus suppresses apoptosis at the early stage of virus infection Clonogenic assay of type a influenza viruses reveals noninfectious cell-killing (apoptosis-inducing) particles Host gene targets for novel influenza therapies elucidated by high-throughput RNA interference screens Influenza B virus ribonucleoprotein is a potent activator of the antiviral kinase PKR Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein X-ray structure of the SH3 domain of the phosphoinositide 3-kinase p85β subunit The Influenza NS1 Protein: What Do We Know in Equine Influenza Virus Pathogenesis?Molecular mechanism behind rotavirus NSP1-mediated PI3 kinase activation: interaction between NSP1 and the p85 subunit of PI3 kinase Potent host-directed small-molecule inhibitors of myxovirus RNA-dependent RNA-polymerases Oncolytic effects of a novel influenza A virus expressing interleukin-15 from the NS reading frame Heat shock protein 90 positively regulates Chikungunya virus replication by stabilizing viral non-structural protein nsP2 during infection Influenza virus non-structural protein 1 (NS1) disrupts interferon signaling Chemical Genomics Identifies the PERK-Mediated Unfolded Protein Stress Response as a Cellular Target for Influenza Virus Inhibition Heterologous SH3-p85beta inhibits influenza A virus replication.Mechanism of influenza A virus NS1 protein interaction with the p85beta, but not the p85alpha, subunit of phosphatidylinositol 3-kinase (PI3K) and up-regulation of PI3K activity.SH3 binding motif 1 in influenza A virus NS1 protein is essential for PI3K/Akt signaling pathway activation.Antiviral activity of baicalin against influenza virus H1N1-pdm09 is due to modulation of NS1-mediated cellular innate immune responses.Avian and 1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling.H5N1 avian influenza virus induces apoptotic cell death in mammalian airway epithelial cells.The NS1 protein of the 1918 pandemic influenza virus blocks host interferon and lipid metabolism pathways Biochemical and structural characterization of the interface mediating interaction between the influenza A virus non-structural protein-1 and a monoclonal antibody Apoptosis, cytokine and chemokine induction by non-structural 1 (NS1) proteins encoded by different influenza subtypes Molecular signatures associated with Mx1-mediated resistance to highly pathogenic influenza virus infection: mechanisms of survival Inhibition of autophagy ameliorates acute lung injury caused by avian influenza A H5N1 infection.Influenza virus A/Beijing/501/2009(H1N1) NS1 interacts with β-tubulin and induces disruption of the microtubule network and apoptosis on A549 cells.Reassortment of NS segments modifies highly pathogenic avian influenza virus interaction with avian hosts and host cells.Emerging antiviral strategies to interfere with influenza virus entry.Genetically engineered, biarsenically labeled influenza virus allows visualization of viral NS1 protein in living cells.Influenza A virus inhibits type I IFN signaling via NF-kappaB-dependent induction of SOCS-3 expression.The NS segment of an H5N1 highly pathogenic avian influenza virus (HPAIV) is sufficient to alter replication efficiency, cell tropism, and host range of an H7N1 HPAIV Transient activation of the PI3K/Akt pathway promotes Newcastle disease virus replication and enhances anti-apoptotic signaling responses Innate immune evasion strategies of influenza viruses Highly pathogenic avian influenza A virus H5N1 NS1 protein induces caspase-dependent apoptosis in human alveolar basal epithelial cells The Ras-PI3K signaling pathway is involved in clathrin-independent endocytosis and the internalization of influenza viruses.Quantitative proteomic analysis of the influenza A virus nonstructural proteins NS1 and NS2 during natural cell infection identifies PACT as an NS1 target protein and antiviral host factor.Prolidase is required for early trafficking events during influenza A virus entry

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P2860

Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses.

http://www.wikidata.org/entity/Q35785139

description

2007 nî lūn-bûn

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2007年の論文

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Influenza A virus NS1 protein ...... apoptotic signaling responses.

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Influenza A virus NS1 protein ...... apoptotic signaling responses.

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Influenza A virus NS1 protein ...... apoptotic signaling responses.

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Influenza A virus NS1 protein ...... apoptotic signaling responses.

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Influenza A virus NS1 protein ...... apoptotic signaling responses.

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Influenza A virus NS1 protein ...... apoptotic signaling responses.

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Journal of Virology

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Influenza A virus NS1 protein ...... apoptotic signaling responses.

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Christina Ehrhardt

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Johannes G Bode

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Mirco Schmolke

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Oliver Planz

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Stephan Pleschka

http://www.w3.org/2001/XMLSchema#string

Thorsten Wolff

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Wiebke Beermann

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P2860

Influenza A virus NS1 protein binds p85beta and activates phosphatidylinositol-3-kinase signaling

Mechanism of activation of protein kinase B by insulin and IGF-1

NS1-Binding protein (NS1-BP): a novel human protein that interacts with the influenza A virus nonstructural NS1 protein is relocalized in the nuclei of infected cells

Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

The phosphoinositide 3-kinase pathway

Influenza virus propagation is impaired by inhibition of the Raf/MEK/ERK signalling cascade.

A novel influenza A virus mitochondrial protein that induces cell death.

Regulation of cell death protease caspase-9 by phosphorylation

Influenza A Virus Lacking the NS1 Gene Replicates in Interferon-Deficient Systems

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3058-3067

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10.1128/JVI.02082-06

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81

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17229704

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1866065

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