Progressive age-related changes similar to age-related macular degeneration in a transgenic mouse model
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Chloroquine treatment of ARPE-19 cells leads to lysosome dilation and intracellular lipid accumulation: possible implications of lysosomal dysfunction in macular degenerationThe unconventional myosin-VIIa associates with lysosomesAnimal models of age related macular degenerationMicrotubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis.RPE necroptosis in response to oxidative stress and in AMDDrusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degenerationComparative pathology of murine mucolipidosis types II and IIICAutophagy and exosomes in the aged retinal pigment epithelium: possible relevance to drusen formation and age-related macular degenerationEmerging biological therapies for age-related macula degeneration.Animals as models of age-related macular degeneration: an imperfect measure of the truth.Novel rodent models for macular researchRetinal ultrastructure of murine models of dry age-related macular degeneration (AMD).Enzymatic degradation of A2E, a retinal pigment epithelial lipofuscin bisretinoid.Knock-down of cathepsin D affects the retinal pigment epithelium, impairs swim-bladder ontogenesis and causes premature death in zebrafish.Understanding photoreceptor outer segment phagocytosis: use and utility of RPE cells in culture.Phagosome maturation during endosome interaction revealed by partial rhodopsin processing in retinal pigment epithelium.Conditional ablation of the choroideremia gene causes age-related changes in mouse retinal pigment epithelium.A novel form of transducin-dependent retinal degeneration: accelerated retinal degeneration in the absence of rod transducinInduction of ectopic retina-like tissue by transgenic expression of neurogenin.Cleavage of Mer tyrosine kinase (MerTK) from the cell surface contributes to the regulation of retinal phagocytosis.A comparison of some organizational characteristics of the mouse central retina and the human maculaProgress and perspectives on the role of RPE cell inflammatory responses in the development of age-related macular degeneration.Lack of alphavbeta5 integrin receptor or its ligand MFG-E8: distinct effects on retinal function.Genetic factors of age-related macular degeneration.Essential role for MFG-E8 as ligand for alphavbeta5 integrin in diurnal retinal phagocytosis.Multi-Functional OCT Enables Longitudinal Study of Retinal Changes in a VLDLR Knockout Mouse Model.2-Phenyl-APB-144-Induced Retinal Pigment Epithelium Degeneration and Its Underlying MechanismsDeletion of Efemp1 Is Protective Against the Development of Sub-RPE Deposits in Mouse Eyes.Photoreceptor phagosome processing defects and disturbed autophagy in retinal pigment epithelium of Cln3Δex1-6 mice modelling juvenile neuronal ceroid lipofuscinosis (Batten disease).Dry age-related macular degeneration like pathology in aged 5XFAD mice: Ultrastructure and microarray analysis.Loss of synchronized retinal phagocytosis and age-related blindness in mice lacking alphavbeta5 integrin.The molecular regulation of organelle transport in mammalian retinal pigment epithelial cells.Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agentsMutations in CTNNA1 cause butterfly-shaped pigment dystrophy and perturbed retinal pigment epithelium integrityRegulation of Phagolysosomal Digestion by Caveolin-1 of the Retinal Pigment Epithelium Is Essential for Vision.Molecular genetics of AMD and current animal models.The age lipid A2E and mitochondrial dysfunction synergistically impair phagocytosis by retinal pigment epithelial cellsMelanoregulin (MREG) modulates lysosome function in pigment epithelial cellsAge and disease-related structural changes in the retinal pigment epithelium.Urinary 6-sulfatoxymelatonin level in age-related macular degeneration patients.
P2860
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P2860
Progressive age-related changes similar to age-related macular degeneration in a transgenic mouse model
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Progressive age-related change ...... on in a transgenic mouse model
@ast
Progressive age-related change ...... on in a transgenic mouse model
@en
type
label
Progressive age-related change ...... on in a transgenic mouse model
@ast
Progressive age-related change ...... on in a transgenic mouse model
@en
prefLabel
Progressive age-related change ...... on in a transgenic mouse model
@ast
Progressive age-related change ...... on in a transgenic mouse model
@en
P2093
P2860
P1476
Progressive age-related change ...... on in a transgenic mouse model
@en
P2093
Chooi-May Lai
Ian Jeffrey Constable
John Papadimitriou
Piroska Elizabeth Rakoczy
Terry Robertson
P2860
P304
P356
10.1016/S0002-9440(10)64427-6
P407
P577
2002-10-01T00:00:00Z