A mechanism for transcriptional repression dependent on the BRCA1 E3 ubiquitin ligase
about
Dysregulation of ubiquitin ligases in cancerBRCA1 and Oxidative StressBRCA1 targets G2/M cell cycle proteins for ubiquitination and proteasomal degradationSubstitution of aspartic acid with glutamic acid at position 67 of the BRCA1 RING domain retains ubiquitin ligase activity and zinc(II) binding with a reduced transition temperature.A design principle underlying the paradoxical roles of E3 ubiquitin ligasesThe UPS: a promising target for breast cancer treatment.BRCA1 represses amphiregulin gene expression.Transcriptional autoregulation by BRCA1.BRCA1/BARD1 complex interacts with steroidogenic factor 1--A potential mechanism for regulation of aromatase expression by BRCA1.Positional analyses of BRCA1-dependent expression in Saccharomyces cerevisiae.Selective mode of action of plumbagin through BRCA1 deficient breast cancer stem cells.Promoters active in interphase are bookmarked during mitosis by ubiquitination.The F-box protein FBXO44 mediates BRCA1 ubiquitination and degradation.Ubiquitination of retinoblastoma family protein 1 potentiates gene-specific repression function.Multiple mechanisms contribute to inhibit transcription in response to DNA damage.BRCA1, hormone, and tissue-specific tumor suppressionThe BRCA1 ubiquitin ligase and homologous recombination repair.Links between genome integrity and BRCA1 tumor suppression.The ubiquitin E3 ligase activity of BRCA1 and its biological functions.Transcriptional characteristics of familial non-BRCA1/BRCA2 breast tumors.
P2860
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P2860
A mechanism for transcriptional repression dependent on the BRCA1 E3 ubiquitin ligase
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
A mechanism for transcriptional repression dependent on the BRCA1 E3 ubiquitin ligase
@ast
A mechanism for transcriptional repression dependent on the BRCA1 E3 ubiquitin ligase
@en
type
label
A mechanism for transcriptional repression dependent on the BRCA1 E3 ubiquitin ligase
@ast
A mechanism for transcriptional repression dependent on the BRCA1 E3 ubiquitin ligase
@en
prefLabel
A mechanism for transcriptional repression dependent on the BRCA1 E3 ubiquitin ligase
@ast
A mechanism for transcriptional repression dependent on the BRCA1 E3 ubiquitin ligase
@en
P2093
P2860
P356
P1476
A mechanism for transcriptional repression dependent on the BRCA1 E3 ubiquitin ligase
@en
P2093
Andrew A Horwitz
El Bachir Affar
George F Heine
Jeffrey D Parvin
P2860
P304
P356
10.1073/PNAS.0610481104
P407
P577
2007-04-09T00:00:00Z