CD44 is required for two consecutive steps in HGF/c-Met signaling.
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Non-small cell lung cancer cells expressing CD44 are enriched for stem cell-like propertiesInterplay between scatter factor receptors and B plexins controls invasive growthTargeted disruption of heparan sulfate interaction with hepatocyte and vascular endothelial growth factors blocks normal and oncogenic signalingSpatial recruitment and activation of the Fes kinase by ezrin promotes HGF-induced cell scatteringRegulation of CD44 alternative splicing by SRm160 and its potential role in tumor cell invasionThe biology of CD44 and HCELL in hematopoiesis: the 'step 2-bypass pathway' and other emerging perspectivesMucin-Type O-Glycosylation in Gastric CarcinogenesisRoles of Proteoglycans and Glycosaminoglycans in Wound Healing and FibrosisKey Roles of Hyaluronan and Its CD44 Receptor in the Stemness and Survival of Cancer Stem CellsEpithelial-mesenchymal plasticity of breast cancer stem cells: implications for metastasis and therapeutic resistanceCD44 Acts as a Signaling Platform Controlling Tumor Progression and MetastasisMET: a critical player in tumorigenesis and therapeutic targetInteractions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and CancerDemonstration of a melanoma-specific CD44 alternative splicing pattern that remains qualitatively stable, but shows quantitative changes during tumour progressionBidirectional interconversion of stem and non-stem cancer cell populations: A reassessment of theoretical models for tumor heterogeneityRoles of c-Met and RON kinases in tumor progression and their potential as therapeutic targetsConcise Review: Emerging Role of CD44 in Cancer Stem Cells: A Promising Biomarker and Therapeutic TargetCD44, Hyaluronan, the Hematopoietic Stem Cell, and Leukemia-Initiating CellsBiology of MET: a double life between normal tissue repair and tumor progressionPhosphatidylinositol 4,5-bisphosphate clusters the cell adhesion molecule CD44 and assembles a specific CD44-Ezrin heterocomplex, as revealed by small angle neutron scatteringMerlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survivalAlternative pre-mRNA splicing regulation in cancer: pathways and programs unhingedHepatocyte growth factor-induced Ras activation requires ERM proteins linked to both CD44v6 and F-actinHeparan sulfate signaling in cancerCD44v6 coordinates tumor matrix-triggered motility and apoptosis resistance.CD44v/CD44s expression patterns are associated with the survival of pancreatic carcinoma patientsMolecular mechanisms of activating c-MET in KSHV+ primary effusion lymphoma.MAP kinase pathways and calcitonin influence CD44 alternate isoform expression in prostate cancer cells.Stable alterations of CD44 isoform expression in prostate cancer cells decrease invasion and growth and alter ligand binding and chemosensitivity.Serglycin in tumor microenvironment promotes non-small cell lung cancer aggressiveness in a CD44-dependent manner.Organotypic specificity of key RET adaptor-docking sites in the pathogenesis of neurocristopathies and renal malformations in mice.Epigenetic drugs can stimulate metastasis through enhanced expression of the pro-metastatic Ezrin gene.Initiation and Maintenance of Gastric Cancer: A Focus on CD44 Variant Isoforms and Cancer Stem Cells.CD44 attenuates activation of the hippo signaling pathway and is a prime therapeutic target for glioblastomaY-box binding protein-1 induces the expression of CD44 and CD49f leading to enhanced self-renewal, mammosphere growth, and drug resistance.PCBP-1 regulates alternative splicing of the CD44 gene and inhibits invasion in human hepatoma cell line HepG2 cells.Stromal hyaluronan interaction with epithelial CD44 variants promotes prostate cancer invasiveness by augmenting expression and function of hepatocyte growth factor and androgen receptorPrognostic significance of CD44s expression in resected non-small cell lung cancer.Mechanisms of HGF/Met signaling to Brk and Sam68 in breast cancer progression.Activation of Ras requires the ERM-dependent link of actin to the plasma membrane.
P2860
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P2860
CD44 is required for two consecutive steps in HGF/c-Met signaling.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
CD44 is required for two consecutive steps in HGF/c-Met signaling.
@ast
CD44 is required for two consecutive steps in HGF/c-Met signaling.
@en
type
label
CD44 is required for two consecutive steps in HGF/c-Met signaling.
@ast
CD44 is required for two consecutive steps in HGF/c-Met signaling.
@en
prefLabel
CD44 is required for two consecutive steps in HGF/c-Met signaling.
@ast
CD44 is required for two consecutive steps in HGF/c-Met signaling.
@en
P2093
P2860
P356
P1433
P1476
CD44 is required for two consecutive steps in HGF/c-Met signaling
@en
P2093
Helmut Ponta
Linfeng Chen
Peter Herrlich
P2860
P304
P356
10.1101/GAD.242602
P577
2002-12-01T00:00:00Z