Molecular mechanism of pharmacological activation of BK channels. - Wikidata - wikimedia - TriplyDB

Molecular mechanism of pharmacological activation of BK channels.

Molecular mechanism of pharmacological activation of BK channels.

http://www.wikidata.org/entity/Q35807499

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BK channels: multiple sensors, one activation gate Resin-acid derivatives as potent electrostatic openers of voltage-gated K channels and suppressors of neuronal excitability BK channel activators and their therapeutic perspectives Calcium- and voltage-gated potassium (BK) channel activators in the 5β-cholanic acid-3α-ol analogue series with modifications in the lateral chain BK channels reveal novel phosphate sensitivity in SNr neurons.Molecular mechanisms underlying the effect of the novel BK channel opener GoSlo: involvement of the S4/S5 linker and the S6 segment.Two distinct effects of PIP2 underlie auxiliary subunit-dependent modulation of Slo1 BK channels.Effects of the novel BK (KCa 1.1) channel opener GoSlo-SR-5-130 are dependent on the presence of BKβ subunits.Single Channel Recordings Reveal Differential β2 Subunit Modulations Between Mammalian and Drosophila BKCa(β2) Channels.Genetic activation of BK currents in vivo generates bidirectional effects on neuronal excitability.Spontaneous and evoked contractions are regulated by PKC-mediated signaling in detrusor smooth muscle: involvement of BK channels.Single-channel biophysical and pharmacological characterizations of native human large-conductance calcium-activated potassium channels in freshly isolated detrusor smooth muscle cells.DiBAC₄(3) hits a "sweet spot" for the activation of arterial large-conductance Ca²⁺-activated potassium channels independently of the β₁-subunit.Modulation of BK Channel Function by Auxiliary Beta and Gamma Subunits.Regulation of BK channels by auxiliary γ subunits.2014 Conway review lecture, Royal Academy of Medicine in Ireland: “S6, drugs and RCK and Bowl”.Molecular Determinants of BK Channel Functional Diversity and Functioning.The smooth muscle-type β1 subunit potentiates activation by DiBAC4(3) in recombinant BK channels.The Slo(w) path to identifying the mitochondrial channels responsible for ischemic protection.Differential efficacy of GoSlo-SR compounds on BKα and BKαγ1-4 channels.Big conductance calcium-activated potassium channel openers control spasticity without sedation.BK channel agonist represents a potential therapeutic approach for lysosomal storage diseases.Multilevel regulation: Controlling BK channels in central clock neurons.CO-independent modification of K+ channels by tricarbonyldichlororuthenium(II) dimer (CORM-2).

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Molecular mechanism of pharmacological activation of BK channels.

http://www.wikidata.org/entity/Q35807499

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2012年论文

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name

Molecular mechanism of pharmacological activation of BK channels.

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Molecular mechanism of pharmacological activation of BK channels.

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Molecular mechanism of pharmacological activation of BK channels.

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Molecular mechanism of pharmacological activation of BK channels.

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Molecular mechanism of pharmacological activation of BK channels.

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Molecular mechanism of pharmacological activation of BK channels

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P2093

Guido Gessner

http://www.w3.org/2001/XMLSchema#string

Malle Soom

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Tomohiko Ohwada

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Toshinori Hoshi

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Yong-Mei Cui

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Yuko Otani

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P2860

LRRC26 auxiliary protein allows BK channel activation at resting voltage without calcium

Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolution

Structure of the gating ring from the human large-conductance Ca(2+)-gated K(+) channel

The RCK2 domain of the human BKCa channel is a calcium sensor

Crystal structure and mechanism of a calcium-gated potassium channel

New disguises for an old channel: MaxiK channel beta-subunits

Primary sequence and immunological characterization of beta-subunit of high conductance Ca(2+)-activated K+ channel from smooth muscle

Calcium sparks in smooth muscle.

A mutually exclusive alternative exon of slo1 codes for a neuronal BK channel with altered function.

BK channel activation: structural and functional insights

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3552-3557

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Stefan H. Heinemann

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221830119

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