Enzymatic completion of mammalian lagging-strand DNA replication.
about
Cloning of the cDNA encoding the large subunit of human RNase HI, a homologue of the prokaryotic RNase HIIHuman exonuclease 1 functionally complements its yeast homologues in DNA recombination, RNA primer removal, and mutation avoidanceThe RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activitiesMolecular interactions of human Exo1 with DNAArginine residues 47 and 70 of human flap endonuclease-1 are involved in DNA substrate interactions and cleavage site determinationHuman DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediatesHuman MUS81 complexes stimulate flap endonuclease 1Antisense-mediated decrease in DNA ligase III expression results in reduced mitochondrial DNA integrityOkazaki fragment maturation: nucleases take centre stageEnzymatic properties of the Caenorhabditis elegans Dna2 endonuclease/helicase and a species-specific interaction between RPA and Dna2Molecular structure and novel DNA binding sites located in loops of flap endonuclease-1 from Pyrococcus horikoshiiPCNA directs type 2 RNase H activity on DNA replication and repair substratesSaccharomyces cerevisiae RNase H(35) functions in RNA primer removal during lagging-strand DNA synthesis, most efficiently in cooperation with Rad27 nucleaseThe RAD52 recombinational repair pathway is essential in pol30 (PCNA) mutants that accumulate small single-stranded DNA fragments during DNA synthesis.The MPH1 gene of Saccharomyces cerevisiae functions in Okazaki fragment processing.The product of the DNA damage-inducible gene of Saccharomyces cerevisiae, DIN7, specifically functions in mitochondriaCleavage specificity of Saccharomyces cerevisiae flap endonuclease 1 suggests a double-flap structure as the cellular substrate.A requirement for recombinational repair in Saccharomyces cerevisiae is caused by DNA replication defects of mec1 mutantsAccumulation of single-stranded DNA and destabilization of telomeric repeats in yeast mutant strains carrying a deletion of RAD27.A yeast replicative helicase, Dna2 helicase, interacts with yeast FEN-1 nuclease in carrying out its essential functionEvidence for a role of FEN1 in maintaining mitochondrial DNA integrityYeast RNase H(35) is the counterpart of the mammalian RNase HI, and is evolutionarily related to prokaryotic RNase HII.Overexpression and hypomethylation of flap endonuclease 1 gene in breast and other cancersMechanisms employed by Escherichia coli to prevent ribonucleotide incorporation into genomic DNA by Pol VMammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrityThe deletion of rnhB in Mycobacterium smegmatis does not affect the level of RNase HII substrates or influence genome stabilityEnzymes and reactions at the eukaryotic DNA replication forkMechanism whereby proliferating cell nuclear antigen stimulates flap endonuclease 1Processing of an HIV replication intermediate by the human DNA replication enzyme FEN1Fidelity of mitotic double-strand-break repair in Saccharomyces cerevisiae: a role for SAE2/COM1Ribonuclease H1-dependent hepatotoxicity caused by locked nucleic acid-modified gapmer antisense oligonucleotidesThe protein components and mechanism of eukaryotic Okazaki fragment maturation.On the roles of Saccharomyces cerevisiae Dna2p and Flap endonuclease 1 in Okazaki fragment processing.Cell cycle-dependent and DNA damage-inducible nuclear localization of FEN-1 nuclease is consistent with its dual functions in DNA replication and repair.Characterization of FEN-1 from Xenopus laevis. cDNA cloning and role in DNA metabolism.Pif1 helicase lengthens some Okazaki fragment flaps necessitating Dna2 nuclease/helicase action in the two-nuclease processing pathway.TbPIF5 is a Trypanosoma brucei mitochondrial DNA helicase involved in processing of minicircle Okazaki fragments.Destabilization of yeast micro- and minisatellite DNA sequences by mutations affecting a nuclease involved in Okazaki fragment processing (rad27) and DNA polymerase delta (pol3-t).Mutational spectrum analysis of RNase H(35) deficient Saccharomyces cerevisiae using fluorescence-based directed termination PCR.Investigating the mechanisms of ribonucleotide excision repair in Escherichia coli
P2860
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P2860
Enzymatic completion of mammalian lagging-strand DNA replication.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Enzymatic completion of mammalian lagging-strand DNA replication.
@ast
Enzymatic completion of mammalian lagging-strand DNA replication.
@en
type
label
Enzymatic completion of mammalian lagging-strand DNA replication.
@ast
Enzymatic completion of mammalian lagging-strand DNA replication.
@en
prefLabel
Enzymatic completion of mammalian lagging-strand DNA replication.
@ast
Enzymatic completion of mammalian lagging-strand DNA replication.
@en
P2093
P2860
P356
P1476
Enzymatic completion of mammalian lagging-strand DNA replication.
@en
P2093
P2860
P304
P356
10.1073/PNAS.91.21.9803
P407
P577
1994-10-01T00:00:00Z