Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: functional impact of disease-related variants on mitochondrial homeostasis.
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Degeneration of Dopaminergic Neurons Due to Metabolic Alterations and Parkinson's DiseaseMitochondrial quality control: decommissioning power plants in neurodegenerative diseasesKnockdown of Hsc70-5/mortalin induces loss of synaptic mitochondria in a Drosophila Parkinson's disease modelCrystal structure of the nucleotide-binding domain of mortalin, the mitochondrial Hsp70 chaperoneEvidence for a common biological pathway linking three Parkinson's disease-causing genes: parkin, PINK1 and DJ-1Heat shock proteins in neurodegenerative disorders and agingMitochondrial quality, dynamics and functional capacity in Parkinson's disease cybrid cell lines selected for Lewy body expression.Apoptotic death of prostate cancer cells by a gonadotropin-releasing hormone-II antagonist.Gene therapy with mitochondrial heat shock protein 70 suppresses visual loss and optic atrophy in experimental autoimmune encephalomyelitis.Identification and functional characterization of nuclear mortalin in human carcinogenesis.The biology of proteostasis in aging and disease.Development of Therapeutics That Induce Mitochondrial Biogenesis for the Treatment of Acute and Chronic Degenerative Diseases.Down-regulation of mortalin exacerbates Aβ-mediated mitochondrial fragmentation and dysfunction.The Broad Impact of TOM40 on Neurodegenerative Diseases in AgingFunctional significance of point mutations in stress chaperone mortalin and their relevance to Parkinson disease.Stoichiometric expression of mtHsp40 and mtHsp70 modulates mitochondrial morphology and cristae structure via Opa1L cleavage.Unfolded protein stress in the endoplasmic reticulum and mitochondria: a role in neurodegenerationEnhanced J-protein interaction and compromised protein stability of mtHsp70 variants lead to mitochondrial dysfunction in Parkinson's diseaseMutations in the heat-shock protein A9 (HSPA9) gene cause the EVEN-PLUS syndrome of congenital malformations and skeletal dysplasia.Mortalin is Expressed by Astrocytes and Decreased in the Midbrain of Parkinson's Disease Patients.The use of primary human fibroblasts for monitoring mitochondrial phenotypes in the field of Parkinson's disease.A plant alkaloid, veratridine, potentiates cancer chemosensitivity by UBXN2A-dependent inhibition of an oncoprotein, mortalin-2.Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction.Human mitochondrial chaperone (mtHSP70) and cysteine desulfurase (NFS1) bind preferentially to the disordered conformation, whereas co-chaperone (HSC20) binds to the structured conformation of the iron-sulfur cluster scaffold protein (ISCU).Resveratrol protects DAergic PC12 cells from high glucose-induced oxidative stress and apoptosis: effect on p53 and GRP75 localization.The impact of mitochondrial DNA and nuclear genes related to mitochondrial functioning on the risk of Parkinson's disease.Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cellsMitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1.Insights into mitochondrial quality control pathways and Parkinson's disease.Integrating pathways of Parkinson's disease in a molecular interaction map.A mitocentric view of Parkinson's disease.Mortalin, apoptosis, and neurodegeneration.Tumor Necrosis Factor-Associated Protein 1 (TRAP1) is Released from the Mitochondria Following 6-hydroxydopamine Treatment.The TIM23 mitochondrial protein import complex: function and dysfunction.α-Synuclein controls mitochondrial calcium homeostasis by enhancing endoplasmic reticulum-mitochondria interactions.Reactivation of protein aggregates by mortalin and Tid1--the human mitochondrial Hsp70 chaperone system.Chaperone-Based Therapies for Disease Modification in Parkinson's Disease.LON is the master protease that protects against protein aggregation in human mitochondria through direct degradation of misfolded proteins.Micropatterning Facilitates the Long-Term Growth and Analysis of iPSC-Derived Individual Human Neurons and Neuronal Networks.Biogenesis of the mitochondrial Hsp70 chaperone
P2860
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P2860
Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: functional impact of disease-related variants on mitochondrial homeostasis.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Dissecting the role of the mit ...... on mitochondrial homeostasis.
@ast
Dissecting the role of the mit ...... on mitochondrial homeostasis.
@en
type
label
Dissecting the role of the mit ...... on mitochondrial homeostasis.
@ast
Dissecting the role of the mit ...... on mitochondrial homeostasis.
@en
prefLabel
Dissecting the role of the mit ...... on mitochondrial homeostasis.
@ast
Dissecting the role of the mit ...... on mitochondrial homeostasis.
@en
P2093
P2860
P50
P356
P1476
Dissecting the role of the mit ...... on mitochondrial homeostasis.
@en
P2093
Carina Schelling
Carola Schiesling
Dirk Woitalla
Hiroki Kato
Lena F Burbulla
Manu Sharma
Peter Bauer
Stephan Jung
P2860
P304
P356
10.1093/HMG/DDQ370
P577
2010-09-02T00:00:00Z