Guanine ribonucleotide depletion inhibits T cell activation. Mechanism of action of the immunosuppressive drug mizoribine.
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Inhibition of T lymphocyte activation in mice heterozygous for loss of the IMPDH II geneTargeted disruption of the inosine 5'-monophosphate dehydrogenase type I gene in miceCurrent state of renal transplant immunosuppression: Present and futureMizoribine: a new approach in the treatment of renal disease.Small elevations of glucose concentration redirect and amplify the synthesis of guanosine 5'-triphosphate in rat isletsEffects of combined administration of FK 506 and the purine biosynthesis inhibitors mizoribine or mycophenolic acid on lymphocyte DNA synthesis and T cell activation molecule expression in human mixed lymphocyte culturesCytokine gene expression in murine lymphocytes activated in the presence of FK 506, bredinin, mycophenolic acid, or brequinar sodiumThe antilymphocytic activity of brequinar sodium and its potentiation by cytidine. Effects on lymphocyte proliferation and cytokine production.Comparative in vitro studies on the immunosuppressive activities of mycophenolic acid, bredinin, FK 506, cyclosporine, and rapamycin.Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferationImmunomodulatory agents in the laboratory and clinic.Mizoribine provides effective treatment of sequential histological change of arteritis and reduction of inflammatory cytokines and chemokines in an animal model of Kawasaki disease.Inosine-5'-monophosphate dehydrogenase is a rate-determining factor for p53-dependent growth regulationA four-drug combination therapy consisting of low-dose tacrolimus, low-dose mycophenolate mofetil, corticosteroids, and mizoribine in living donor renal transplantation: A randomized study.Safety and efficacy of mizoribine in patients with connective tissue diseases other than rheumatoid arthritis.Ancillary Activity: Beyond Core Metabolism in Immune Cells.Novel inosine monophosphate dehydrogenase inhibitor VX-944 induces apoptosis in multiple myeloma cells primarily via caspase-independent AIF/Endo G pathway.New immunosuppressive drugs in organ transplantation.A factor secreted by a human pulmonary alveolar epithelial-like cell line blocks T-cell proliferation between G1 and S phase.Safety, tolerability and pharmacokinetics of higher-dose mizoribine in healthy male volunteers.Comparative in vitro studies on the immunosuppressive effects of purine and pyrimidine synthesis inhibitors.Ribavirin inhibits protein synthesis and cell proliferation induced by mitogenic factors in primary human and rat hepatocytes.Synthesis and antimicrobial evaluation of novel pyrazolones and pyrazolone nucleosides.Internally ratiometric fluorescent sensors for evaluation of intracellular GTP levels and distribution.Regulation of inosine-5'-monophosphate dehydrogenase type II gene expression in human T cells. Role for a novel 5' palindromic octamer sequence.Regulation of the human inosine monophosphate dehydrogenase type I gene. Utilization of alternative promoters.Efficacy of mizoribine and prednisolone combination therapy in adult patients with IgA vasculitis.Mizoribine: mode of action and effects in clinical use.Toward Developing Chemical Modulators of Hsp60 as Potential Therapeutics.Efficacy of weekly mizoribine pulse therapy in refractory lupus nephritis
P2860
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P2860
Guanine ribonucleotide depletion inhibits T cell activation. Mechanism of action of the immunosuppressive drug mizoribine.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
Guanine ribonucleotide depleti ...... nosuppressive drug mizoribine.
@ast
Guanine ribonucleotide depleti ...... nosuppressive drug mizoribine.
@en
type
label
Guanine ribonucleotide depleti ...... nosuppressive drug mizoribine.
@ast
Guanine ribonucleotide depleti ...... nosuppressive drug mizoribine.
@en
prefLabel
Guanine ribonucleotide depleti ...... nosuppressive drug mizoribine.
@ast
Guanine ribonucleotide depleti ...... nosuppressive drug mizoribine.
@en
P2093
P2860
P356
P1476
Guanine ribonucleotide depleti ...... nosuppressive drug mizoribine.
@en
P2093
B S Mitchell
C B Thompson
G Sinclair
P2860
P304
P356
10.1172/JCI115101
P407
P577
1991-03-01T00:00:00Z