Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesity.
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Identification of a 30-base pair regulatory element and novel DNA binding protein that regulates the human GLUT4 promoter in transgenic miceInsulin down-regulates expression of the insulin-responsive glucose transporter (GLUT4) gene: effects on transcription and mRNA turnoverIdentifying the links between obesity, insulin resistance and beta-cell function: potential role of adipocyte-derived cytokines in the pathogenesis of type 2 diabetesMolecular epidemiologic evidence for diabetogenic effects of dioxin exposure in U.S. Air force veterans of the Vietnam warTransdermal delivery of insulin by amidated pectin hydrogel matrix patch in streptozotocin-induced diabetic rats: effects on some selected metabolic parametersNovel Approach to Identify Potential Bioactive Plant Metabolites: Pharmacological and Metabolomics Analyses of Ethanol and Hot Water Extracts of Several Canadian Medicinal Plants of the Cree of Eeyou IstcheeInsulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway.Differential modulation of diet-induced obesity and adipocyte functionality by human apolipoprotein E3 and E4 in micePear pomace ethanol extract improves insulin resistance through enhancement of insulin signaling pathway without lipid accumulation.Acute inhibition of fatty acid import inhibits GLUT4 transcription in adipose tissue, but not skeletal or cardiac muscle tissue, partly through liver X receptor (LXR) signaling.Regulation of glucose transporters--implications for insulin resistance states.The SLC2 (GLUT) family of membrane transporters.Transmembrane glucose transport in skeletal muscle of patients with non-insulin-dependent diabetes.Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha.The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase.Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesityHigh fat diet-induced hyperglycemia: prevention by low level expression of a glucose transporter (GLUT4) minigene in transgenic mice.Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitusExpression of an insulin-responsive glucose transporter (GLUT4) minigene in transgenic mice: effect of exercise and role in glucose homeostasis.The role of the Niemann-Pick disease, type C1 protein in adipocyte insulin action.Evidence coupling increased hexosamine biosynthesis pathway activity to membrane cholesterol toxicity and cortical filamentous actin derangement contributing to cellular insulin resistance.Selective insulin resistance in adipocytesInsulin resistant states and insulin signaling.Restoration of insulin responsiveness in skeletal muscle of morbidly obese patients after weight loss. Effect on muscle glucose transport and glucose transporter GLUT4.Female offspring sired by diet induced obese male mice display impaired blastocyst development with molecular alterations to their ovaries, oocytes and cumulus cellsFacilitative glucose transporters: regulatory mechanisms and dysregulation in diabetesGLUT4 exocytosis.Class II histone deacetylases downregulate GLUT4 transcription in response to increased cAMP signaling in cultured adipocytes and fasting miceRegulated expression of an insulin-responsive glucose transporter (GLUT4) minigene in 3T3-L1 adipocytes and transgenic mice.Basic Fibroblast Growth Factor Inhibits Apoptosis and Promotes Proliferation of Adipose-Derived Mesenchymal Stromal Cells Isolated from Patients with Type 2 Diabetes by Reducing Cellular Oxidative Stress.Substance P enhances the activation of AMPK and cellular lipid accumulation in 3T3‑L1 cells in response to high levels of glucoseDecreased transcription of ChREBP-α/β isoforms in abdominal subcutaneous adipose tissue of obese adolescents with prediabetes or early type 2 diabetes: associations with insulin resistance and hyperglycemiaTransgenic mice expressing the human GLUT4/muscle-fat facilitative glucose transporter protein exhibit efficient glycemic controlNeurolytic celiac plexus block enhances skeletal muscle insulin signaling and attenuates insulin resistance in GK rats.Insulin signalling mechanisms for triacylglycerol storage.Moderate GLUT4 overexpression improves insulin sensitivity and fasting triglyceridemia in high-fat diet-fed transgenic mice.miRNA-93 inhibits GLUT4 and is overexpressed in adipose tissue of polycystic ovary syndrome patients and women with insulin resistance.De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health.Hexosamine biosynthesis pathway flux contributes to insulin resistance via altering membrane phosphatidylinositol 4,5-bisphosphate and cortical filamentous actinEnvironmental contaminants as risk factors for developing diabetes.
P2860
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P2860
Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesity.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
Pretranslational suppression o ...... diabetes mellitus and obesity.
@ast
Pretranslational suppression o ...... diabetes mellitus and obesity.
@en
type
label
Pretranslational suppression o ...... diabetes mellitus and obesity.
@ast
Pretranslational suppression o ...... diabetes mellitus and obesity.
@en
prefLabel
Pretranslational suppression o ...... diabetes mellitus and obesity.
@ast
Pretranslational suppression o ...... diabetes mellitus and obesity.
@en
P2093
P2860
P356
P1476
Pretranslational suppression o ...... diabetes mellitus and obesity.
@en
P2093
J M Molina
M J Birnbaum
T P Ciaraldi
T P Huecksteadt
W T Garvey
P2860
P304
P356
10.1172/JCI115068
P407
P577
1991-03-01T00:00:00Z