Dominant, toxic gain-of-function mutations in gars lead to non-cell autonomous neuropathology.
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Evolutionary Limitation and Opportunities for Developing tRNA Synthetase Inhibitors with 5-Binding-Mode ClassificationThe aminoacyl-tRNA synthetases of Drosophila melanogasterTrk receptor signaling and sensory neuron fate are perturbed in human neuropathy caused by Gars mutations.Compound heterozygous mutations in glycyl-tRNA synthetase (GARS) cause mitochondrial respiratory chain dysfunction.Two crystal structures reveal design for repurposing the C-Ala domain of human AlaRS.Human aminoacyl-tRNA synthetases in diseases of the nervous system.Peripheral neuropathy via mutant tRNA synthetases: Inhibition of protein translation provides a possible explanation.Methodological advances in imaging intravital axonal transport.Neuropilin 1 sequestration by neuropathogenic mutant glycyl-tRNA synthetase is permissive to vascular homeostasisA WHEP Domain Regulates the Dynamic Structure and Activity of Caenorhabditis elegans Glycyl-tRNA SynthetaseTranscriptomic comparison of Drosophila snRNP biogenesis mutants reveals mutant-specific changes in pre-mRNA processing: implications for spinal muscular atrophy.The role of tRNA synthetases in neurological and neuromuscular disorders.Plexin-Semaphorin Signaling Modifies Neuromuscular Defects in a Drosophila Model of Peripheral Neuropathy.Structural control of caspase-generated glutamyl-tRNA synthetase by appended noncatalytic WHEP domains.A novel multisystem disease associated with recessive mutations in the tyrosyl-tRNA synthetase (YARS) gene.
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P2860
Dominant, toxic gain-of-function mutations in gars lead to non-cell autonomous neuropathology.
description
2015 nî lūn-bûn
@nan
2015年の論文
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2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
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2015年论文
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name
Dominant, toxic gain-of-functi ...... ell autonomous neuropathology.
@ast
Dominant, toxic gain-of-functi ...... ell autonomous neuropathology.
@en
type
label
Dominant, toxic gain-of-functi ...... ell autonomous neuropathology.
@ast
Dominant, toxic gain-of-functi ...... ell autonomous neuropathology.
@en
prefLabel
Dominant, toxic gain-of-functi ...... ell autonomous neuropathology.
@ast
Dominant, toxic gain-of-functi ...... ell autonomous neuropathology.
@en
P2093
P2860
P50
P356
P1476
Dominant, toxic gain-of-functi ...... cell autonomous neuropathology
@en
P2093
Ji-Long Liu
Stuart J Grice
William W Motley
P2860
P304
P356
10.1093/HMG/DDV176
P577
2015-05-13T00:00:00Z