A primary microcephaly protein complex forms a ring around parental centrioles.
about
Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndromeMutations in CENPE define a novel kinetochore-centromeric mechanism for microcephalic primordial dwarfismHuman microcephaly protein CEP135 binds to hSAS-6 and CPAP, and is required for centriole assemblyProduction of Basal Bodies in bulk for dense multicilia formationRegulation of the centrosome cycleCiliogenesis and the DNA damage response: a stressful relationshipCerebral cortex expansion and folding: what have we learned?Basal bodies across eukaryotes series: basal bodies in the freshwater planarian Schmidtea mediterraneaProliferation control in neural stem and progenitor cellsBuilding a ninefold symmetrical barrel: structural dissections of centriole assemblyGenetic changes shaping the human brainDiseases associated with defective responses to DNA damageThe Seckel syndrome and centrosomal protein Ninein localizes asymmetrically to stem cell centrosomes but is not required for normal development, behavior, or DNA damage response in Drosophilap53 protects against genome instability following centriole duplication failureA CEP215-HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancerSAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architectureNew frontiers: discovering cilia-independent functions of cilia proteinsCentriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplicationMDM1 is a microtubule-binding protein that negatively regulates centriole duplicationA Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium InterfaceThe Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesisCEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombinationMicrocephaly models in the developing zebrafish retinal neuroepithelium point to an underlying defect in metaphase progression.Loss of centrioles causes chromosomal instability in vertebrate somatic cells.MCPH1: a window into brain development and evolution.Deregulation of microcephalin and ASPM expression are correlated with epithelial ovarian cancer progression.The centriole duplication cycle.Small organelle, big responsibility: the role of centrosomes in development and disease.A molecular mechanism of mitotic centrosome assembly in DrosophilaA missense mutation in the PISA domain of HsSAS-6 causes autosomal recessive primary microcephaly in a large consanguineous Pakistani family.Renal-retinal ciliopathy gene Sdccag8 regulates DNA damage response signalingCby1 promotes Ahi1 recruitment to a ring-shaped domain at the centriole-cilium interface and facilitates proper cilium formation and function.Cep63 and cep152 cooperate to ensure centriole duplicationThe centrosome and its duplication cycleMorphological and functional aspects of progenitors perturbed in cortical malformations.Two Polo-like kinase 4 binding domains in Asterless perform distinct roles in regulating kinase stability.A novel single base pair duplication in WDR62 causes primary microcephaly.STED microscopy with optimized labeling density reveals 9-fold arrangement of a centriole protein.Mutations in CDK5RAP2 cause Seckel syndromeMeier-Gorlin syndrome mutations disrupt an Orc1 CDK inhibitory domain and cause centrosome reduplication
P2860
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P2860
A primary microcephaly protein complex forms a ring around parental centrioles.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
A primary microcephaly protein complex forms a ring around parental centrioles.
@ast
A primary microcephaly protein complex forms a ring around parental centrioles.
@en
type
label
A primary microcephaly protein complex forms a ring around parental centrioles.
@ast
A primary microcephaly protein complex forms a ring around parental centrioles.
@en
prefLabel
A primary microcephaly protein complex forms a ring around parental centrioles.
@ast
A primary microcephaly protein complex forms a ring around parental centrioles.
@en
P2093
P2860
P50
P356
P1433
P1476
A primary microcephaly protein complex forms a ring around parental centrioles
@en
P2093
Adeline K Nicholas
C Geoffrey Woods
Clive D'Santos
Joo-Hee Sir
Maryam Khurshid
P2860
P2888
P304
P356
10.1038/NG.971
P407
P577
2011-10-09T00:00:00Z