Targeting DDX3 with a small molecule inhibitor for lung cancer therapy. - Wikidata - wikimedia - TriplyDB

Targeting DDX3 with a small molecule inhibitor for lung cancer therapy.

Targeting DDX3 with a small molecule inhibitor for lung cancer therapy.

http://www.wikidata.org/entity/Q35822589

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Multifunctional DDX3: dual roles in various cancer development and its related signaling pathways DDX3, a potential target for cancer treatment Coupling between the DEAD-box RNA helicases Ded1p and eIF4A Identification of novel cancer therapeutic targets using a designed and pooled shRNA library screen Identification of the DEAD box RNA helicase DDX3 as a therapeutic target in colorectal cancer Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3.DDX3 promotes tumor invasion in colorectal cancer via the CK1ε/Dvl2 axis.Analog sensitive chemical inhibition of the DEAD-box protein DDX3 Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents.PLGA nanoparticle formulation of RK-33: an RNA helicase inhibitor against DDX3 DDX3X promotes the biogenesis of a subset of miRNAs and the potential roles they played in cancer development.Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress.DHX33 Transcriptionally Controls Genes Involved in the Cell Cycle DDX59 promotes DNA replication in lung adenocarcinoma.The prognostic effect of DDX3 upregulation in distant breast cancer metastases.Combination treatment using DDX3 and PARP inhibitors induces synthetic lethality in BRCA1-proficient breast cancer.RK-33 Radiosensitizes Prostate Cancer Cells by Blocking the RNA Helicase DDX3 Wnt signaling as potential therapeutic target in lung cancer.Wanted DEAD/H or Alive: Helicases Winding Up in Cancers.Nuclear DDX3 expression predicts poor outcome in colorectal and breast cancer.(DEAD)-box RNA helicase 3 modulates NF-κB signal pathway by controlling the phosphorylation of PP2A-C subunit.RNA helicase DDX3: a novel therapeutic target in Ewing sarcoma.DDX3 localizes to the centrosome and prevents multipolar mitosis by epigenetically and translationally modulating p53 expression.The helicase, DDX3X, interacts with poly(A)-binding protein 1 (PABP1) and caprin-1 at the leading edge of migrating fibroblasts and is required for efficient cell spreading Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation.Targeting mitochondrial translation by inhibiting DDX3: a novel radiosensitization strategy for cancer treatment.Future perspectives in melanoma research "Melanoma Bridge", Napoli, November 30th-3rd December 2016.Dengue Virus Capsid Interacts with DDX3X-A Potential Mechanism for Suppression of Antiviral Functions in Dengue Infection.Targeting RNA helicases in cancer: The translation trap.Role of DDX3 in the pathogenesis of inflammatory bowel disease.MOLIERE: Automatic Biomedical Hypothesis Generation System.Targeted inactivation of murine Ddx3x: essential roles of Ddx3x in placentation and embryogenesis.Global Effects of DDX3 Inhibition on Cell Cycle Regulation Identified by a Combined Phosphoproteomics and Single Cell Tracking Approach.DDX5 RNA Helicases: Emerging Roles in Viral Infection.Patent highlights: December 2015-January 2016.DDX3X RNA helicase affects breast cancer cell cycle progression by regulating expression of KLF4 Abnormal expression of YEATS4 associates with poor prognosis and promotes cell proliferation of hepatic carcinoma cell by regulation the TCEA1/DDX3 axis

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Targeting DDX3 with a small molecule inhibitor for lung cancer therapy.

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Targeting DDX3 with a small molecule inhibitor for lung cancer therapy.

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Targeting DDX3 with a small molecule inhibitor for lung cancer therapy.

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Targeting DDX3 with a small molecule inhibitor for lung cancer therapy.

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Targeting DDX3 with a small molecule inhibitor for lung cancer therapy.

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Targeting DDX3 with a small molecule inhibitor for lung cancer therapy.

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Targeting DDX3 with a small molecule inhibitor for lung cancer therapy.

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EMBO Molecular Medicine

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Targeting DDX3 with a small molecule inhibitor for lung cancer therapy.

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Anne Levine

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Ashley Irving

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Atul Kondaskar

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Dorian Korz

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Elsken van der Wall

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Evan A Bordt

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Jing Zeng

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Kathleen Gabrielson

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Khaled Aziz

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Leslie Cope

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Expression of DDX3 is directly modulated by hypoxia inducible factor-1 alpha in breast epithelial cells

Regulation and mechanisms of mammalian double-strand break repair

DDX3, a DEAD box RNA helicase, is deregulated in hepatitis virus-associated hepatocellular carcinoma and is involved in cell growth control

Human DDX3 functions in translation and interacts with the translation initiation factor eIF3

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

Identification of an antiapoptotic protein complex at death receptors

Candidate tumor suppressor DDX3 RNA helicase specifically represses cap-dependent translation by acting as an eIF4E inhibitory protein

Dissecting the genomic complexity underlying medulloblastoma

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

Cancer statistics, 2013

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10.15252/EMMM.201404368

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2015-03-27T00:00:00Z

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274081897

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