about
Metazoan Hsp70-based protein disaggregases: emergence and mechanismsNeuroprotective Mechanisms Mediated by CDK5 InhibitionInfluence of Aluminium and EGCG on Fibrillation and Aggregation of Human Islet Amyloid PolypeptideType 2 diabetes and quality of life.Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2Glucose- and temperature-sensitive nanoparticles for insulin deliveryAlterations in Hippocampal Oxidative Stress, Expression of AMPA Receptor GluR2 Subunit and Associated Spatial Memory Loss by Bacopa monnieri Extract (CDRI-08) in Streptozotocin-Induced Diabetes Mellitus Type 2 Miceβ-Cell Deficit in Obese Type 2 Diabetes, a Minor Role of β-Cell Dedifferentiation and Degranulation.Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity.Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes.Factors That Shape Eukaryotic tRNAomes: Processing, Modification and Anticodon-Codon Use.Structural, morphological, and functional diversity of amyloid oligomers.Eukaryotic aggresomes: from a model of conformational diseases to an emerging type of immobilized biocatalyzers.Understanding Pre-Eclampsia Using Alzheimer's Etiology: An Intriguing Viewpoint.Targeting Insulin-Degrading Enzyme to Treat Type 2 Diabetes MellitusStructural and functional diversity among amyloid proteins: Agents of disease, building blocks of biology, and implications for molecular engineering.Prion-Like Protein Aggregates and Type 2 Diabetes.Shaping proteostasis at the cellular, tissue, and organismal level.Foldamer-mediated manipulation of a pre-amyloid toxinUnfolding Novel Mechanisms of Polyphenol Flavonoids for Better Glycaemic Control: Targeting Pancreatic Islet Amyloid Polypeptide (IAPP).AmyPro: a database of proteins with validated amyloidogenic regions.Reduced Abundance and Subverted Functions of Proteins in Prion-Like Diseases: Gained Functions Fascinate but Lost Functions Affect Aetiology.Common fibrillar spines of amyloid-β and human Islet Amyloid Polypeptide revealed by Micro Electron Diffraction and inhibitors developed using structure-based design.Design and study of lipopeptide inhibitors on preventing aggregation of human islet amyloid polypeptide residues 11-20.A Genetic Tool to Track Protein Aggregates and Control Prion Inheritance.A component analysis of the free energies of folding of 35 proteins: A consensus view on the thermodynamics of folding at the molecular level.Fluorescent Probe DCVJ Shows High Sensitivity for Characterization of Amyloid β-Peptide Early in the Lag Phase.Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases.Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism.The absence of specific yeast heat-shock proteins leads to abnormal aggregation and compromised autophagic clearance of mutant Huntingtin proteins.BACE2 suppression promotes β-cell survival and function in a model of type 2 diabetes induced by human islet amyloid polypeptide overexpression.Inhibition of the Aggregation and Toxicity of the Minimal Amyloidogenic Fragment of Tau by Its Pro-Substituted Analogues.Multiple functions of insulin-degrading enzyme: a metabolic crosslight?Conformational switching within dynamic oligomers underpins toxic gain-of-function by diabetes-associated amyloid.Pancreatic β cells overexpressing hIAPP impaired mitophagy and unbalanced mitochondrial dynamics.Mitochondrial Chaperones in the Brain: Safeguarding Brain Health and Metabolism?Endoplasmic Reticulum Stress in Metabolic Disorders.An engineered, quantifiable in vitro model for analysing the effect of proteostasis-targeting drugs on tissue physical propertiesDifferent Structural Conformers of Monomeric α-Synuclein Identified after Lyophilizing and FreezingmTORC1 Overactivation as a Key Aging Factor in the Progression to Type 2 Diabetes Mellitus
P2860
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P2860
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Type 2 diabetes as a protein misfolding disease.
@ast
Type 2 diabetes as a protein misfolding disease.
@en
type
label
Type 2 diabetes as a protein misfolding disease.
@ast
Type 2 diabetes as a protein misfolding disease.
@en
prefLabel
Type 2 diabetes as a protein misfolding disease.
@ast
Type 2 diabetes as a protein misfolding disease.
@en
P2093
P2860
P1476
Type 2 diabetes as a protein misfolding disease
@en
P2093
Abhisek Mukherjee
Claudio Soto
Diego Morales-Scheihing
P2860
P304
P356
10.1016/J.MOLMED.2015.04.005
P577
2015-05-18T00:00:00Z