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HIV-1-specific interleukin-21+ CD4+ T cell responses contribute to durable viral control through the modulation of HIV-specific CD8+ T cell functionIL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent mannerIL-21 Signaling in ImmunityAnticancer Cytokines: Biology and Clinical Effects of Interferon-α2, Interleukin (IL)-2, IL-15, IL-21, and IL-12S1PR2 links germinal center confinement and growth regulationMembrane-bound IL-21 promotes sustained ex vivo proliferation of human natural killer cellsThe Biological Effects of IL-21 Signaling on B-Cell-Mediated Responses in Organ TransplantationPIM1 kinase phosphorylates the human transcription factor FOXP3 at serine 422 to negatively regulate its activity under inflammationIL-21: roles in immunopathology and cancer therapyIL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cellsInterleukin-21 induces the differentiation of human umbilical cord blood CD34-lineage- cells into pseudomature lytic NK cells.IL21R expressing CD14+CD16+ monocytes expand in multiple myeloma patients leading to increased osteoclasts.B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans.Association between IL-21 gene rs907715 polymorphisms and Graves' disease in a Southern Chinese population.Polyfunctional T-cell responses are disrupted by the ovarian cancer ascites environment and only partially restored by clinically relevant cytokines.IL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumoursIL-21 receptor signalling partially mediates Th2-mediated allergic airway responsesThe Production IL-21 and VEGF in UVB-irradiated Human Keratinocyte Cell Line, HaCaTInterleukin-21 promotes germinal center reaction by skewing the follicular regulatory T cell to follicular helper T cell balance in autoimmune BXD2 miceIntrinsic IL-21 signaling is critical for CD8 T cell survival and memory formation in response to vaccinia viral infection.T follicular helper cells mediate expansion of regulatory B cells via IL-21 in Lupus-prone MRL/lpr mice.Critical role for IL-21 in both primary and memory anti-viral CD8+ T-cell responses.Interleukin 21 signaling in B cells is required for efficient establishment of murine gammaherpesvirus latencyEarly Th1 cell differentiation is marked by a Tfh cell-like transition.Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors.Selective reduction of post-selection CD8 thymocyte proliferation in IL-15Rα deficient mice.Overexpression of microRNA-155 increases IL-21 mediated STAT3 signaling and IL-21 production in systemic lupus erythematosus.Opposing roles of STAT1 and STAT3 in IL-21 function in CD4+ T cellsDirect and immune-mediated cytotoxicity of interleukin-21 contributes to antitumor effects in mantle cell lymphoma.IL-6 triggers IL-21 production by human CD4+ T cells to drive STAT3-dependent plasma cell differentiation in B cells.Interleukin-21 promotes osteoclastogenesis in RAW264.7 cells through the PI3K/AKT signaling pathway independently of RANKLIL-27 Induces Th17 Differentiation in the Absence of STAT1 SignalingIL-21 acts as a promising therapeutic target in systemic lupus erythematosus by regulating plasma cell differentiation.B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1Common gamma chain cytokines in combinatorial immune strategies against cancerIL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy.STAT3-mediated up-regulation of BLIMP1 Is coordinated with BCL6 down-regulation to control human plasma cell differentiation.Signal transducer and activator of transcription 3: a year in review.Interleukin 21: a cytokine/cytokine receptor system that has come of ageInterleukin-21 overexpression dominates T cell response to Epstein-Barr virus in a fatal case of X-linked lymphoproliferative syndrome type 1
P2860
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P2860
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
The molecular basis of IL-21-mediated proliferation.
@ast
The molecular basis of IL-21-mediated proliferation.
@en
type
label
The molecular basis of IL-21-mediated proliferation.
@ast
The molecular basis of IL-21-mediated proliferation.
@en
prefLabel
The molecular basis of IL-21-mediated proliferation.
@ast
The molecular basis of IL-21-mediated proliferation.
@en
P2093
P2860
P1433
P1476
The molecular basis of IL-21-mediated proliferation.
@en
P2093
David E Levy
Esther Casas
Rosanne Spolski
Warren J Leonard
P2860
P304
P356
10.1182/BLOOD-2006-10-054973
P407
P577
2007-01-18T00:00:00Z