Integrin alpha1beta1 and transforming growth factor-beta1 play distinct roles in alport glomerular pathogenesis and serve as dual targets for metabolic therapy.
about
Angiotensin converting enzyme inhibitor therapy in children with Alport syndrome: effect on urinary albumin, TGF-beta, and nitrite excretionStage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease.Integrins in kidney diseaseProteinuria precedes podocyte abnormalities inLamb2-/- mice, implicating the glomerular basement membrane as an albumin barrierKey role of alpha(1)beta(1)-integrin in the activation of PI3-kinase-Akt by flow (shear stress) in resistance arteriesAbnormal basement membrane in the inner ear and the kidney of the Mpv17-/- mouse strain: ultrastructural and immunohistochemical investigationsLaminin α1 regulates age-related mesangial cell proliferation and mesangial matrix accumulation through the TGF-β pathwayLaminin α2-mediated focal adhesion kinase activation triggers Alport glomerular pathogenesis.Collagen XIII induced in vascular endothelium mediates alpha1beta1 integrin-dependent transmigration of monocytes in renal fibrosisTransforming growth factor-beta, basement membrane, and epithelial-mesenchymal transdifferentiation: implications for fibrosis in kidney disease.Searching for a treatment for Alport syndrome using mouse modelsFocusing on the glomerular slit diaphragm: podocin enters the pictureUpregulated expression of integrin α1 in mesangial cells and integrin α3 and vimentin in podocytes of Col4a3-null (Alport) miceBone-marrow-derived stem cells repair basement membrane collagen defects and reverse genetic kidney disease.A hypomorphic mutation in the mouse laminin alpha5 gene causes polycystic kidney disease.Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases.Matrix metalloproteinase dysregulation in the stria vascularis of mice with Alport syndrome: implications for capillary basement membrane pathology.Lack of integrin alpha1beta1 leads to severe glomerulosclerosis after glomerular injury.Microvascular basement membranes in diabetes mellitus.Forced expression of laminin beta1 in podocytes prevents nephrotic syndrome in mice lacking laminin beta2, a model for Pierson syndromeRole for macrophage metalloelastase in glomerular basement membrane damage associated with alport syndromeAlphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse.Mechanisms and consequences of TGF-ß overexpression by podocytes in progressive podocyte disease.Renal fibrosis. Extracellular matrix microenvironment regulates migratory behavior of activated tubular epithelial cellsA human-mouse chimera of the alpha3alpha4alpha5(IV) collagen protomer rescues the renal phenotype in Col4a3-/- Alport mice.Alpha11 beta1 integrin-dependent regulation of periodontal ligament function in the erupting mouse incisor.Precision renal medicine: a roadmap towards targeted kidney fibrosis therapies.Tissue-type plasminogen activator promotes murine myofibroblast activation through LDL receptor-related protein 1-mediated integrin signalingInsights into the mechanisms of renal fibrosis: is it possible to achieve regression?X-Linked Alport Dogs Demonstrate Mesangial Filopodial Invasion of the Capillary Tuft as an Early Event in Glomerular Damage.Dynamic structural changes are observed upon collagen and metal ion binding to the integrin α1 I domain.Glomerular basement membrane and related glomerular diseaseGlomerular pathology in Alport syndrome: a molecular perspective.Integrin alpha1beta1 regulates matrix metalloproteinases via P38 mitogen-activated protein kinase in mesangial cells: implications for Alport syndrome.Physiology and pathology of collagen receptors.Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstructionProgressive morphological and functional defects in retinas from alpha1 integrin-null mice.Albumin contributes to kidney disease progression in Alport syndrome.α1β1 integrin/Rac1-dependent mesangial invasion of glomerular capillaries in Alport syndrome.Biomechanical strain causes maladaptive gene regulation, contributing to Alport glomerular disease.
P2860
Q24802921-983158FE-BB4F-44DB-8F20-A32944CA2845Q25256594-4E17FCAF-8E56-47C0-9BC2-6FA4E20BDA79Q27010694-CD5974D2-E911-428E-BC46-CCF7AC6A076EQ28512854-0951FD89-C92F-4360-9689-A5B4006F49CFQ28576516-07B5D892-F2F6-47A4-BA9D-85504E830C13Q28590581-0E10944B-296A-41C4-9521-526633B0BCF3Q33708674-7A563F51-FFEA-4450-91CC-B27957D8FBB7Q33734236-37CBA5C0-5ED0-4651-90D8-851D19423F0EQ34254557-72B39081-2872-4481-A4B9-BA4D20B8BE21Q34389106-CCBE97CC-6735-4536-9835-AEDF9F37BAAFQ34453272-D6D2C19E-B842-4FDB-A791-0DA72ECF0058Q34489954-7A2AC01E-5A63-4674-BEFC-76E7368E874BQ34510473-0D30F1F4-9981-4941-BA87-8F80FCD0C569Q34624477-4395FA54-1150-4264-BF55-A5265B7189DAQ34696383-E47EF6FD-9DCF-4704-8AA8-3F6F3A98E496Q34792468-8D668944-5C1C-4508-9A59-01C72DC772B5Q35087786-297E7600-F5B3-4328-B571-8FE97CFE88FEQ35103022-394AAE7D-168D-4A38-B6BB-9DB76F690536Q35170462-3781BB75-F75F-46E9-B5A9-E877FC315484Q35217074-15D587CB-5E18-45E9-B680-CDFF75DF4205Q35221882-56452EAA-F94E-44B5-9273-81D46459EF38Q35570438-3B3AB195-E781-4067-A266-CFD0B35F4713Q35649310-9C56D889-C9DF-4C25-B870-C84849E1CDD7Q35747935-C9F78935-FF9E-4A69-A8DE-D31B1A1B52A1Q35792074-6554BC30-52BF-4384-9E13-43ABE221638CQ35857122-89E15D88-DCD3-4499-A165-22099B7E7F5DQ36015077-50723652-F775-435F-AD5B-7A4998162772Q36151652-4E2A2C64-6564-44A5-AC7E-1FB09FAE34B1Q36188436-299DDC0F-BF1F-4126-B13E-B7368B865C5DQ36222337-3F9DBC2D-A55A-4A88-9C01-F02379485293Q36294881-6F82827A-DE7D-4833-A503-C17FAF92E911Q36336238-419556E0-C8A9-41AF-8CA3-ED94B97FBA44Q36359599-19E3F043-F4E7-446D-A3E7-3E784223D221Q36482190-8BB5D929-18B1-4F71-85CC-1DC6A82C82CAQ36854099-42FFEF78-768D-457F-ACEB-3CF6F9F687C1Q36991087-72DFADFF-D9DD-4D1D-B441-5FCD9ED26184Q37059169-8CD12A42-D7DE-4406-AEAD-4707D81C2F9EQ37139486-32CED48C-1E8B-427F-8BDC-236D7295BF9DQ37218239-EA774AF1-0355-4844-AD34-503482D5167FQ37427367-A0670EE6-3041-41BA-949C-6DE769F05C85
P2860
Integrin alpha1beta1 and transforming growth factor-beta1 play distinct roles in alport glomerular pathogenesis and serve as dual targets for metabolic therapy.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Integrin alpha1beta1 and trans ...... targets for metabolic therapy.
@ast
Integrin alpha1beta1 and trans ...... targets for metabolic therapy.
@en
type
label
Integrin alpha1beta1 and trans ...... targets for metabolic therapy.
@ast
Integrin alpha1beta1 and trans ...... targets for metabolic therapy.
@en
prefLabel
Integrin alpha1beta1 and trans ...... targets for metabolic therapy.
@ast
Integrin alpha1beta1 and trans ...... targets for metabolic therapy.
@en
P2093
P2860
P1476
Integrin alpha1beta1 and trans ...... targets for metabolic therapy.
@en
P2093
A Amatucci
D Cosgrove
P2860
P304
P356
10.1016/S0002-9440(10)64802-X
P407
P577
2000-11-01T00:00:00Z