Autoimmune disease risk variant of IFIH1 is associated with increased sensitivity to IFN-α and serologic autoimmunity in lupus patients. - Wikidata - wikimedia - TriplyDB

Autoimmune disease risk variant of IFIH1 is associated with increased sensitivity to IFN-α and serologic autoimmunity in lupus patients.

Autoimmune disease risk variant of IFIH1 is associated with increased sensitivity to IFN-α and serologic autoimmunity in lupus patients.

http://www.wikidata.org/entity/Q35832527

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Dysregulation of antiviral helicase pathways in systemic lupus erythematosus Identification of Candidate Predictors of Lupus Flare TLRs and interferons: a central paradigm in autoimmunity LGP2 synergy with MDA5 in RLR-mediated RNA recognition and antiviral signaling Advances in lupus genetics IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production Genetics of systemic lupus erythematosus: immune responses and end organ resistance to damage.Osteopontin alleles are associated with clinical characteristics in systemic lupus erythematosus.Hepatic expression profiles in retroviral infection: relevance to drug hypersensitivity risk.Type I interferon in the pathogenesis of lupus.Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus SLE peripheral blood B cell, T cell and myeloid cell transcriptomes display unique profiles and each subset contributes to the interferon signature Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus.Interferon regulatory factors: critical mediators of human lupus.Kinetic discrimination of self/non-self RNA by the ATPase activity of RIG-I and MDA5 MDA5-filament, dynamics and disease.The autoimmune disease risk allele of UBE2L3 in African American patients with systemic lupus erythematosus: a recessive effect upon subphenotypes.Metagenomics and personalized medicine.Gene-expression-guided selection of candidate loci and molecular phenotype analyses enhance genetic discovery in systemic lupus erythematosus.Immunogenetics of systemic lupus erythematosus: A comprehensive review.The genetics of lupus: a functional perspective.Association of IFIH1 and pro-inflammatory mediators: Potential new clues in SLE-associated pathogenesis.Genetics of Lupus Nephritis: Clinical Implications.The type I interferons: Basic concepts and clinical relevance in immune-mediated inflammatory diseases.The new perspectives on genetic studies of type 2 diabetes and thyroid diseases Increased serum type I interferon activity in organ-specific autoimmune disorders: clinical, imaging, and serological associations.Activation of the Interferon Pathway is Dependent Upon Autoantibodies in African-American SLE Patients, but Not in European-American SLE Patients.Familial aggregation of high tumor necrosis factor alpha levels in systemic lupus erythematosus.Genetic variation near IRF8 is associated with serologic and cytokine profiles in systemic lupus erythematosus and multiple sclerosis.Genetics of the type I interferon pathway in systemic lupus erythematosus.Functional genetic polymorphisms in ILT3 are associated with decreased surface expression on dendritic cells and increased serum cytokines in lupus patients Immunology in the clinic review series; focus on type 1 diabetes and viruses: the innate immune response to enteroviruses and its possible role in regulating type 1 diabetes.Interferon regulatory factor 5 in the pathogenesis of systemic lupus erythematosus.The genetics of innate immunity sensors and human disease.Association of IFIH1 rs1990760 polymorphism with susceptibility to autoimmune diseases: a meta-analysis.Antiviral RNA recognition and assembly by RLR family innate immune sensors.Immune sensing of nucleic acids in inflammatory skin diseases.Genetic variation in pattern recognition receptors: functional consequences and susceptibility to infectious disease.Systemic Lupus Erythematosus--A Disease with A Dysregulated Type I Interferon System.

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Autoimmune disease risk variant of IFIH1 is associated with increased sensitivity to IFN-α and serologic autoimmunity in lupus patients.

http://www.wikidata.org/entity/Q35832527

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Autoimmune disease risk varian ...... utoimmunity in lupus patients.

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Autoimmune disease risk varian ...... utoimmunity in lupus patients.

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Autoimmune disease risk varian ...... utoimmunity in lupus patients.

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JIMMUNOL.1100857

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Journal of Immunology

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Autoimmune disease risk varian ...... utoimmunity in lupus patients.

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Akaash A Kumar

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Barbara E Drevlow

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Beverly S Franek

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Galen Guerrero

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James S Grober

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Kyriakos A Kirou

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Laura S Zaacks

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Lewis M Cohen

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Maria Badaracco

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Marissa Kumabe

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P2860

The role of genetic variation near interferon-kappa in systemic lupus erythematosus

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes

PLINK: a tool set for whole-genome association and population-based linkage analyses

Interferon alpha-induced lupus: proof of principle

Network analysis of associations between serum interferon-α activity, autoantibodies, and clinical features in systemic lupus erythematosus

High serum IFN-alpha activity is a heritable risk factor for systemic lupus erythematosus

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.

The 1982 revised criteria for the classification of systemic lupus erythematosus

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Timothy B. Niewold

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2011-06-24T00:00:00Z

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