E3 ligases in T cell anergy--turning immune responses into tolerance.
about
Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cellsT-cell regulator RNF125/TRAC-1 belongs to a novel family of ubiquitin ligases with zinc fingers and a ubiquitin-binding domainMolecular mechanisms of T-cell receptor and costimulatory molecule ligation/blockade in autoimmune disease therapy.Therapeutic blockade of T-cell antigen receptor signal transduction and costimulation in autoimmune diseaseYin-Yang of costimulation: crucial controls of immune tolerance and function.The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation.T-cell tolerance or function is determined by combinatorial costimulatory signals.Defects in the Bcl-2-regulated apoptotic pathway lead to preferential increase of CD25 low Foxp3+ anergic CD4+ T cells.Cbl-b Deficiency in Mice Results in Exacerbation of Acute and Chronic Stages of Allergic Asthma.Cbl- and Nedd4-family ubiquitin ligases: balancing tolerance and immunityThe yin and yang of protein kinase C-theta (PKCθ): a novel drug target for selective immunosuppression.E3 ubiquitin ligases in T-cell tolerance.Molecular mechanisms of T-cell tolerance.T-cell tolerance in cancer.Modulation of Immune Cell Functions by the E3 Ligase Cbl-b.NFAT2 is a critical regulator of the anergic phenotype in chronic lymphocytic leukaemia.Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness.Grail controls Th2 cell development by targeting STAT6 for degradationImmune Regulation by Ubiquitin Tagging as Checkpoint Code.
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E3 ligases in T cell anergy--turning immune responses into tolerance.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
E3 ligases in T cell anergy--turning immune responses into tolerance.
@ast
E3 ligases in T cell anergy--turning immune responses into tolerance.
@en
type
label
E3 ligases in T cell anergy--turning immune responses into tolerance.
@ast
E3 ligases in T cell anergy--turning immune responses into tolerance.
@en
prefLabel
E3 ligases in T cell anergy--turning immune responses into tolerance.
@ast
E3 ligases in T cell anergy--turning immune responses into tolerance.
@en
P2860
P356
P1476
E3 ligases in T cell anergy--turning immune responses into tolerance.
@en
P2093
Anjana Rao
Vigo Heissmeyer
P2860
P356
10.1126/STKE.2412004PE29
P577
2004-07-06T00:00:00Z