Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling.
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Function, regulation and pathological roles of the Gab/DOS docking proteinsPhosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking proteinThe Scaffolding Protein, Grb2-associated Binder-1, in Skeletal Muscles and Terminal Schwann Cells Regulates Postnatal Neuromuscular Synapse Maturation.Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart.Galpha(i1) and Galpha(i3) are required for epidermal growth factor-mediated activation of the Akt-mTORC1 pathwayEndothelial Grb2-associated binder 1 is crucial for postnatal angiogenesisEssential roles of Gab1 tyrosine phosphorylation in growth factor-mediated signaling and angiogenesisFollowing nerve injury neuregulin-1 drives microglial proliferation and neuropathic pain via the MEK/ERK pathway.Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of pulmonary arterial hypertension.Interaction of scaffolding adaptor protein Gab1 with tyrosine phosphatase SHP2 negatively regulates IGF-I-dependent myogenic differentiation via the ERK1/2 signaling pathwayMolecular Characterization of Striated Muscle-Specific Gab1 Isoform as a Critical Signal Transducer for Neuregulin-1/ErbB Signaling in Cardiomyocytes.The role of Neuregulin-1beta/ErbB signaling in the heart.Cardiac Gab1 deletion leads to dilated cardiomyopathy associated with mitochondrial damage and cardiomyocyte apoptosisNeuregulin-1 attenuates mortality associated with experimental cerebral malaria.Docking proteins.DNA microarray-based gene expression profiling of estrogenic chemicals.Recent advances of adapter proteins in the regulation of heart diseases.Increased levels of Gab1 and Gab2 adaptor proteins skew interleukin-4 (IL-4) signaling toward M2 macrophage-driven pulmonary fibrosis in mice.Gab1 adaptor protein acts as a gatekeeper to balance hepatocyte death and proliferation during acetaminophen-induced liver injury in mice.Scaffolding protein Gab1 regulates myeloid dendritic cell migration in allergic asthma.Gab1 Is Modulated by Chronic Hypoxia in Children with Cyanotic Congenital Heart Defect and Its Overexpression Reduces Apoptosis in Rat Neonatal Cardiomyocytes.Extracellular Signal-Regulated Kinases 1 and 2 Phosphorylate Gab2 To Promote a Negative-Feedback Loop That Attenuates Phosphoinositide 3-Kinase/Akt SignalingGab docking proteins in cardiovascular disease, cancer, and inflammation.ErbB receptors protect the perfused heart against injury induced by epinephrine combined with low-flow ischemia.Necrostatin-1 inhibits Hmgb1-IL-23/IL-17 pathway and attenuates cardiac ischemia reperfusion injury.Transcriptionally inducible Pleckstrin homology-like domain family A member 1 attenuates ErbB receptor activity by inhibiting receptor oligomerization.Cooperative interaction of hepatocyte growth factor and neuregulin regulates Schwann cell migration and proliferation through Grb2-associated binder-2 in peripheral nerve repair.Loss of Gab1 adaptor protein in hepatocytes aggravates experimental liver fibrosis in mice.Inhibition of RIP1-dependent necrosis prevents adverse cardiac remodeling after myocardial ischemia-reperfusion in vivo.Expression and secretion of neuregulin-1 in cardiac microvascular endothelial cells treated with angiogenic factors.Grb2-associated binder 1 is essential for cardioprotection against ischemia/reperfusion injury.
P2860
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P2860
Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Gab family proteins are essent ...... a neuregulin-1/ErbB signaling.
@ast
Gab family proteins are essent ...... a neuregulin-1/ErbB signaling.
@en
type
label
Gab family proteins are essent ...... a neuregulin-1/ErbB signaling.
@ast
Gab family proteins are essent ...... a neuregulin-1/ErbB signaling.
@en
prefLabel
Gab family proteins are essent ...... a neuregulin-1/ErbB signaling.
@ast
Gab family proteins are essent ...... a neuregulin-1/ErbB signaling.
@en
P2093
P2860
P356
P1476
Gab family proteins are essent ...... a neuregulin-1/ErbB signaling.
@en
P2093
Atsunori Kamiya
Gou Young Koh
Hirofumi Sawa
Hisao Hirota
Katsuya Okawa
Keigo Nishida
Kinya Otsu
Makiko Maeda
Manami Sone
Masahiro Narimatsu
P2860
P304
P356
10.1172/JCI30651
P407
P577
2007-07-01T00:00:00Z