Amplification and demultiplexing in insulin-regulated Akt protein kinase pathway in adipocytes.
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Kinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/Insulin-like Growth Factor (IGF)-1 Signaling PathwaySorting nexin 5 and dopamine d1 receptor regulate the expression of the insulin receptor in human renal proximal tubule cells.Rab5 activity regulates GLUT4 sorting into insulin-responsive and non-insulin-responsive endosomal compartments: a potential mechanism for development of insulin resistanceTribbles homolog 3 attenuates mammalian target of rapamycin complex-2 signaling and inflammation in the diabetic kidneyISL1 regulates peroxisome proliferator-activated receptor γ activation and early adipogenesis via bone morphogenetic protein 4-dependent and -independent mechanisms.Sirt1 inhibits akt2-mediated porcine adipogenesis potentially by direct protein-protein interaction.The role of the Niemann-Pick disease, type C1 protein in adipocyte insulin action.A generalised enzyme kinetic model for predicting the behaviour of complex biochemical systemsSelective insulin resistance in adipocytesDevelopment of a new model system to dissect isoform specific Akt signalling in adipocytes.The Rab GTPase-activating protein TBC1D4/AS160 contains an atypical phosphotyrosine-binding domain that interacts with plasma membrane phospholipids to facilitate GLUT4 trafficking in adipocytes.Greater insulin-mediated Akt phosphorylation concomitant with heterogeneous effects on phosphorylation of Akt substrates in soleus of calorie-restricted ratsConstitutive STAT3 phosphorylation contributes to skeletal muscle insulin resistance in type 2 diabetes.Acute knockdown of the insulin receptor or its substrates Irs1 and 2 in 3T3-L1 adipocytes suppresses adiponectin productionMammalian tribbles homologs at the crossroads of endoplasmic reticulum stress and Mammalian target of rapamycin pathways.Overlapped metabolic and therapeutic links between Alzheimer and diabetes.Cross-talks via mTORC2 can explain enhanced activation in response to insulin in diabetic patients.Rac-1 superactivation triggers insulin-independent glucose transporter 4 (GLUT4) translocation that bypasses signaling defects exerted by c-Jun N-terminal kinase (JNK)- and ceramide-induced insulin resistance.A novel PKB/Akt inhibitor, MK-2206, effectively inhibits insulin-stimulated glucose metabolism and protein synthesis in isolated rat skeletal muscle.Constitutive Activation of AKT2 in Humans Leads to Hypoglycemia Without Fatty Liver or Metabolic Dyslipidemia.A receptor state space model of the insulin signalling system in glucose transport.Quantitative Analysis of Robustness of Dynamic Response and Signal Transfer in Insulin mediated PI3K/AKT Pathway.LXR is a negative regulator of glucose uptake in human adipocytes.An improved Akt reporter reveals intra- and inter-cellular heterogeneity and oscillations in signal transduction.Insulin action and resistance in obesity and type 2 diabetes.Impaired Akt phosphorylation in insulin-resistant human muscle is accompanied by selective and heterogeneous downstream defects.Rac1 muscle knockout exacerbates the detrimental effect of high-fat diet on insulin-stimulated muscle glucose uptake independently of Akt.Phosphorylation-Dependent Inhibition of Akt1
P2860
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P2860
Amplification and demultiplexing in insulin-regulated Akt protein kinase pathway in adipocytes.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Amplification and demultiplexi ...... kinase pathway in adipocytes.
@ast
Amplification and demultiplexi ...... kinase pathway in adipocytes.
@en
type
label
Amplification and demultiplexi ...... kinase pathway in adipocytes.
@ast
Amplification and demultiplexi ...... kinase pathway in adipocytes.
@en
prefLabel
Amplification and demultiplexi ...... kinase pathway in adipocytes.
@ast
Amplification and demultiplexi ...... kinase pathway in adipocytes.
@en
P2093
P2860
P50
P356
P1476
Amplification and demultiplexi ...... n kinase pathway in adipocytes
@en
P2093
Ansu Kumar
Christopher C Meoli
Jacqueline Stöckli
Poh-Sim Khoo
Shi-Xiong Tan
Shireen Vali
P2860
P304
P356
10.1074/JBC.M111.318238
P407
P577
2011-12-29T00:00:00Z