Mechanism of RPE cell death in α-crystallin deficient mice: a novel and critical role for MRP1-mediated GSH efflux - Wikidata - wikimedia - TriplyDB

Mechanism of RPE cell death in α-crystallin deficient mice: a novel and critical role for MRP1-mediated GSH efflux

Mechanism of RPE cell death in α-crystallin deficient mice: a novel and critical role for MRP1-mediated GSH efflux

http://www.wikidata.org/entity/Q35839878

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Protection of retina by αB crystallin in sodium iodate induced retinal degeneration Targeting the Achilles heel of multidrug-resistant cancer by exploiting the fitness cost of resistance.Multidrug resistance protein 1 (MRP1, ABCC1), a "multitasking" ATP-binding cassette (ABC) transporter.αB-Crystallin Regulates Subretinal Fibrosis by Modulation of Epithelial-Mesenchymal Transition Humanin Protects RPE Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Upregulation of Mitochondrial Glutathione.Deficiency of αB crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunction Novel roles for α-crystallins in retinal function and disease.Glutathione efflux and cell death.Alpha crystallins in the retinal pigment epithelium and implications for the pathogenesis and treatment of age-related macular degeneration Antiapoptotic properties of α-crystallin-derived peptide chaperones and characterization of their uptake transporters in human RPE cells.Loss of Mrp1 Potentiates Doxorubicin-Induced Cytotoxicity in Neonatal Mouse Cardiomyocytes and Cardiac Fibroblasts Role of antioxidant enzymes and small molecular weight antioxidants in the pathogenesis of age-related macular degeneration (AMD)Identification of proteins that interact with alpha A-crystallin using a human proteome microarray.Metabolism of 4-Hydroxy-7-oxo-5-heptenoic Acid (HOHA) Lactone by Retinal Pigmented Epithelial Cells.

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Mechanism of RPE cell death in α-crystallin deficient mice: a novel and critical role for MRP1-mediated GSH efflux

http://www.wikidata.org/entity/Q35839878

description

2012 nî lūn-bûn

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Christine Spee

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David R Hinton

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Parameswaran G Sreekumar

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Stephen J Ryan

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P2860

Human alphaA- and alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine-induced apoptosis

Exacerbation of retinal degeneration in the absence of alpha crystallins in an in vivo model of chemically induced hypoxia

alpha-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stress

Alpha-crystallin can function as a molecular chaperone

Regulation of GSH in alphaA-expressing human lens epithelial cell lines and in alphaA knockout mouse lenses.

Age-related macular degeneration--emerging pathogenetic and therapeutic concepts.

What determines the switch between atrophic and neovascular forms of age related macular degeneration? - the role of BMP4 induced senescence

Mitochondrial glutathione, a key survival antioxidant.

αB crystallin is apically secreted within exosomes by polarized human retinal pigment epithelium and provides neuroprotection to adjacent cells

Oxidative damage and protection of the RPE.

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