Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis. - Wikidata - wikimedia - TriplyDB

Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis.

Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis.

http://www.wikidata.org/entity/Q35843679

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Genome-wide association analysis of metabolic traits in a birth cohort from a founder population Induction of Neuron-Specific Degradation of Coenzyme A Models Pantothenate Kinase-Associated Neurodegeneration by Reducing Motor Coordination in Mice Cofilin/Twinstar phosphorylation levels increase in response to impaired coenzyme a metabolism Modulation of Pantothenate Kinase 3 Activity by Small Molecules that Interact with the Substrate/Allosteric Regulatory Domain Pantothenate kinase 1 is required to support the metabolic transition from the fed to the fasted state Germline deletion of pantothenate kinases 1 and 2 reveals the key roles for CoA in postnatal metabolism Localization and regulation of mouse pantothenate kinase 2 Compartmentalization of mammalian pantothenate kinases Genetic Characterization of Coenzyme A Biosynthesis Reveals Essential Distinctive Functions during Malaria Parasite Development in Blood and Mosquito.Pantethine rescues a Drosophila model for pantothenate kinase-associated neurodegeneration Brain, blood, and iron: perspectives on the roles of erythrocytes and iron in neurodegeneration.Postprandial regulation of hepatic microRNAs predicted to target the insulin pathway in rainbow trout.A liver-specific defect of Acyl-CoA degradation produces hyperammonemia, hypoglycemia and a distinct hepatic Acyl-CoA pattern Pank1 deletion in leptin-deficient mice reduces hyperglycaemia and hyperinsulinaemia and modifies global metabolism without affecting insulin resistance Living on the edge: substrate competition explains loss of robustness in mitochondrial fatty-acid oxidation disorders.Vitamin B5 and N-Acetylcysteine in Nonalcoholic Steatohepatitis: A Preclinical Study in a Dietary Mouse Model.Correction of a genetic deficiency in pantothenate kinase 1 using phosphopantothenate replacement therapy.Deregulated coenzyme A, loss of metabolic flexibility and diabetes.Metabolic activation of CaMKII by coenzyme A.Glycine conjugation: importance in metabolism, the role of glycine N-acyltransferase, and factors that influence interindividual variation.A new perspective on the importance of glycine conjugation in the metabolism of aromatic acids.Coenzyme A, more than 'just' a metabolic cofactor.Exploiting the coenzyme A biosynthesis pathway for the identification of new antimalarial agents: the case for pantothenamides.Methods for measuring CoA and CoA derivatives in biological samples.Extracellular 4'-phosphopantetheine is a source for intracellular coenzyme A synthesis.Excess coenzyme A reduces skeletal muscle performance and strength in mice overexpressing human PANK2.Impaired Coenzyme A metabolism affects histone and tubulin acetylation in Drosophila and human cell models of pantothenate kinase associated neurodegeneration.Allosteric Regulation of Mammalian Pantothenate Kinase.Acetyl-4'-phosphopantetheine is stable in serum and prevents phenotypes induced by pantothenate kinase deficiency.Pantothenate kinase-associated neurodegeneration: insights from a Drosophila model.De novo CoA biosynthesis is required to maintain DNA integrity during development of the Drosophila nervous system.PanK4 inhibits pancreatic beta-cell apoptosis by decreasing the transcriptional level of pro-caspase-9.Nudt19 is a renal CoA diphosphohydrolase with biochemical and regulatory properties that are distinct from the hepatic Nudt7 isoform.Variation in pantothenate kinase type determines the pantothenamide mode of action and impacts on coenzyme A salvage biosynthesis.A framework for large-scale metabolome drug profiling links coenzyme A metabolism to the toxicity of anti-cancer drug dichloroacetate A therapeutic approach to pantothenate kinase associated neurodegeneration

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Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis.

http://www.wikidata.org/entity/Q35843679

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Chemical knockout of pantothen ...... epatic coenzyme A homeostasis.

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Chemical knockout of pantothen ...... epatic coenzyme A homeostasis.

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Chemical knockout of pantothen ...... epatic coenzyme A homeostasis.

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Chemical knockout of pantothen ...... epatic coenzyme A homeostasis.

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Chemistry and Biology

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Chemical knockout of pantothen ...... epatic coenzyme A homeostasis.

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Brett R Wenner

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Charles O Rock

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Christopher B Newgard

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Kristopher G Virga

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Olga R Ilkayeva

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Robert D Stevens

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Shigeru Chohnan

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Yong-Mei Zhang

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P2860

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

Cloning and characterization of a eukaryotic pantothenate kinase gene (panK) from Aspergillus nidulans.

Role of feedback regulation of pantothenate kinase (CoaA) in control of coenzyme A levels in Escherichia coli

An isoform of hPANK2, deficient in pantothenate kinase-associated neurodegeneration, localizes to mitochondria

A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome

Cloning, sequencing, and expression of the pantothenate kinase (coaA) gene of Escherichia coli

Kinetics and regulation of pantothenate kinase from Escherichia coli

Mitochondrial localization of human PANK2 and hypotheses of secondary iron accumulation in pantothenate kinase-associated neurodegeneration

Regulation of coenzyme A biosynthesis

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6428420

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