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Metabolites of ginger component [6]-shogaol remain bioactive in cancer cells and have low toxicity in normal cells: chemical synthesis and biological evaluationGinger compound [6]-shogaol and its cysteine-conjugated metabolite (M2) activate Nrf2 in colon epithelial cells in vitro and in vivoIntestinal, portal, and peripheral profiles of daikenchuto (TU-100)'s active ingredients after oral administration.Identification of phase II metabolites of thiol-conjugated [6]-shogaol in mouse urine using high-performance liquid chromatography tandem mass spectrometry.Cysteine-conjugated metabolite of ginger component [6]-shogaol serves as a carrier of [6]-shogaol in cancer cells and in mice.Metabolism of ginger component [6]-shogaol in liver microsomes from mouse, rat, dog, monkey, and human.Characterization of thiol-conjugated metabolites of ginger components shogaols in mouse and human urine and modulation of the glutathione levels in cancer cells by [6]-shogaol[10]-Gingerdiols as the major metabolites of [10]-gingerol in zebrafish embryos and in humans and their hematopoietic effects in zebrafish embryos.Gastroprotective [6]-Gingerol Aspirinate as a Novel Chemopreventive Prodrug of Aspirin for Colon Cancer.6-Paradol and 6-Shogaol, the Pungent Compounds of Ginger, Promote Glucose Utilization in Adipocytes and Myotubes, and 6-Paradol Reduces Blood Glucose in High-Fat Diet-Fed Mice.Induction of lung cancer cell apoptosis through a p53 pathway by [6]-shogaol and its cysteine-conjugated metabolite M2.Invadopodia-associated proteins blockade as a novel mechanism for 6-shogaol and pterostilbene to reduce breast cancer cell motility and invasion.Cysteine-conjugated metabolites of ginger components, shogaols, induce apoptosis through oxidative stress-mediated p53 pathway in human colon cancer cells.Oat avenanthramide-C (2c) is biotransformed by mice and the human microbiota into bioactive metabolites.Glucuronidation and its impact on the bioactivity of [6]-shogaol.
P2860
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P2860
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Metabolism of [6]-shogaol in mice and in cancer cells.
@ast
Metabolism of [6]-shogaol in mice and in cancer cells.
@en
type
label
Metabolism of [6]-shogaol in mice and in cancer cells.
@ast
Metabolism of [6]-shogaol in mice and in cancer cells.
@en
prefLabel
Metabolism of [6]-shogaol in mice and in cancer cells.
@ast
Metabolism of [6]-shogaol in mice and in cancer cells.
@en
P2093
P2860
P356
P1476
Metabolism of [6]-shogaol in mice and in cancer cells.
@en
P2093
Dominique Soroka
Huadong Chen
Lishuang Lv
Renaud F Warin
Shengmin Sang
Tiffany A Parks
Xiaoxin Chen
Yingdong Zhu
P2860
P304
P356
10.1124/DMD.111.043331
P577
2012-01-13T00:00:00Z