Absence of beta7 integrin results in less graft-versus-host disease because of decreased homing of alloreactive T cells to intestine
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Ceacam1 separates graft-versus-host-disease from graft-versus-tumor activity after experimental allogeneic bone marrow transplantationIndoleamine 2,3-dioxygenase is a critical regulator of acute graft-versus-host disease lethalityThe cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host diseaseDepletion of host CCR7(+) dendritic cells prevented donor T cell tissue tropism in anti-CD3-conditioned recipients.The triterpenoid CDDO-Me delays murine acute graft-versus-host disease with the preservation of graft-versus-tumor effects after allogeneic bone marrow transplantation.Advances in graft-versus-host disease biology and therapy.Up-Regulation of alpha4beta7 integrin on peripheral T cell subsets correlates with the development of acute intestinal graft-versus-host disease following allogeneic stem cell transplantation.Shift of graft-versus-host-disease target organ tropism by dietary vitamin A.A diagnostic window for the treatment of acute graft-versus-host disease prior to visible clinical symptoms in a murine model.Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVLA repertoire-independent and cell-intrinsic defect in murine GVHD induction by effector memory T cells.MicroRNA-17-92 controls T-cell responses in graft-versus-host disease and leukemia relapse in mice.Pathophysiology of acute graft-versus-host disease: recent advances.Beta2 integrins separate graft-versus-host disease and graft-versus-leukemia effectsOrgan-derived dendritic cells have differential effects on alloreactive T cells.A critical role for the retinoic acid signaling pathway in the pathophysiology of gastrointestinal graft-versus-host disease.In vivo trafficking and survival of cytokine-induced killer cells resulting in minimal GVHD with retention of antitumor activityAdoptively transferred TRAIL+ T cells suppress GVHD and augment antitumor activityGraft-versus-host disease after double-unit cord blood transplantation has unique features and an association with engrafting unit-to-recipient HLA match.PLZF confers effector functions to donor T cells that preserve graft-versus-tumor effects while attenuating GVHDLow Paneth cell numbers at onset of gastrointestinal graft-versus-host disease identify patients at high risk for nonrelapse mortalityAbsence of P-selectin in recipients of allogeneic bone marrow transplantation ameliorates experimental graft-versus-host disease.Pharmacologic inhibition of PKCα and PKCθ prevents GVHD while preserving GVL activity in mice.Acute graft-versus-host disease: from the bench to the bedside.PKCtheta is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice.Inducing the tryptophan catabolic pathway, indoleamine 2,3-dioxygenase (IDO), for suppression of graft-versus-host disease (GVHD) lethality.Role of beta7 integrins in intestinal lymphocyte homing and retention.An early-biomarker algorithm predicts lethal graft-versus-host disease and survival.New perspectives on the biology of acute GVHD.Intestinal T lymphocyte homing is associated with gastric emptying and epithelial barrier function in critically ill: a prospective observational study.New ways to separate graft-versus-host disease and graft-versus-tumour effects after allogeneic haematopoietic stem cell transplantation.Immunology of hematopoietic stem cell transplant.State-of-the-art acute and chronic GVHD treatment.Recombinant IL-7/HGFβ hybrid cytokine separates acute graft-versus-host-disease from graft-versus-tumour activity by altering donor T cell trafficking.Altered homeostatic regulation of innate and adaptive immunity in lower gastrointestinal tract GVHD pathogenesis.Predictive Value of Clinical Findings and Plasma Biomarkers after Fourteen Days of Prednisone Treatment for Acute Graft-versus-host Disease.αEβ7 Integrin Identifies Subsets of Pro-Inflammatory Colonic CD4+ T Lymphocytes in Ulcerative Colitis.Integrin β7-mediated regulation of multiple myeloma cell adhesion, migration, and invasion.Unique patterns of CD8+ T-cell-mediated organ damage in the Act-mOVA/OT-I model of acute graft-versus-host disease.Colitogenic effector T cells: roles of gut-homing integrin, gut antigen specificity and γδ T cells.
P2860
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P2860
Absence of beta7 integrin results in less graft-versus-host disease because of decreased homing of alloreactive T cells to intestine
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Absence of beta7 integrin resu ...... oreactive T cells to intestine
@ast
Absence of beta7 integrin resu ...... oreactive T cells to intestine
@en
type
label
Absence of beta7 integrin resu ...... oreactive T cells to intestine
@ast
Absence of beta7 integrin resu ...... oreactive T cells to intestine
@en
prefLabel
Absence of beta7 integrin resu ...... oreactive T cells to intestine
@ast
Absence of beta7 integrin resu ...... oreactive T cells to intestine
@en
P2093
P2860
P1433
P1476
Absence of beta7 integrin resu ...... oreactive T cells to intestine
@en
P2093
Adam A Kochman
Elisha Waldman
George F Murphy
Glenn Heller
Jeffrey M Eng
Marcel R M van den Brink
Onder Alpdogan
Stephanie J Muriglan
Theis H Terwey
P2860
P304
P356
10.1182/BLOOD-2005-08-3445
P407
P50
P577
2005-11-15T00:00:00Z