The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth.
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Eph receptors and ephrin ligands: important players in angiogenesis and tumor angiogenesisStructural and biophysical characterization of the EphB4*ephrinB2 protein-protein interaction and receptor specificityGene expression profiling identifies EPHB4 as a potential predictive biomarker in colorectal cancer patients treated with bevacizumab.Novel strategy for selection of monoclonal antibodies against highly conserved antigens: phage library panning against ephrin-B2 displayed on yeastHsp90 inhibitors are efficacious against Kaposi Sarcoma by enhancing the degradation of the essential viral gene LANA, of the viral co-receptor EphA2 as well as other client proteinsPEGylation potentiates the effectiveness of an antagonistic peptide that targets the EphB4 receptor with nanomolar affinityDisturbed Expression of EphB4, but Not EphrinB2, Inhibited Bone Regeneration in an In Vivo Inflammatory MicroenvironmentCan self-inhibitory peptides be derived from the interfaces of globular protein-protein interactions?PDGFRβ reverses EphB4 signaling in alveolar rhabdomyosarcoma.The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesisSoluble EphB4 inhibition of PDGF-induced RPE migration in vitro.Novel EphB4 monoclonal antibodies modulate angiogenesis and inhibit tumor growth.Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis.Eph receptors and ephrins in cancer: bidirectional signalling and beyond.Essential roles of EphB receptors and EphrinB ligands in endothelial cell function and angiogenesis.The differential expression of EphB2 and EphB4 receptor kinases in normal bladder and in transitional cell carcinoma of the bladderEPHB4 gene polymorphisms and risk of intracranial hemorrhage in patients with brain arteriovenous malformations.Inhibition of Eph receptor-ephrin ligand interaction by tea polyphenols.Lentivirus vector-mediated knockdown of erythropoietin-producing hepatocellular carcinoma receptors B4 inhibits laser-induced choroidal neovascularization.EphB4 as a therapeutic target in mesotheliomaEphB4 expression in pterygium is associated with microvessel densityErythropoietin promotes bone formation through EphrinB2/EphB4 signaling.Coculture of stem cells from apical papilla and human umbilical vein endothelial cell under hypoxia increases the formation of three-dimensional vessel-like structures in vitro.Eph receptors and ephrins as targets for cancer therapy.A disalicylic acid-furanyl derivative inhibits ephrin binding to a subset of Eph receptorsSustained small interfering RNA delivery by mesoporous silicon particlesEndogenous IL-12 triggers an antiangiogenic program in melanoma cells.Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusionSuppression of Wnt1-induced mammary tumor growth and lower serum insulin in offspring exposed to maternal blueberry diet suggest early dietary influence on developmental programmingNipah virus envelope-pseudotyped lentiviruses efficiently target ephrinB2-positive stem cell populations in vitro and bypass the liver sink when administered in vivoThe role of Ephs, Ephrins, and growth factors in Kaposi sarcoma and implications of EphrinB2 blockade.Soluble ephrin-B2 mediates apoptosis in retinal neovascularization and in endothelial cells.Constitutive expression of IL-12R beta 2 on human multiple myeloma cells delineates a novel therapeutic target.EphB4 tyrosine kinase stimulation inhibits growth of MDA-MB-231 breast cancer cells in a dose and time dependent manner.Enhancing radiosensitization in EphB4 receptor-expressing Head and Neck Squamous Cell Carcinomas.Ephrin expression and function in cancer.Axon guidance molecules in vascular patterning.Novel targets for VEGF-independent anti-angiogenic drugs.The dynamics of developmental and tumor angiogenesis-a comparison.Therapeutic targeting of EPH receptors and their ligands.
P2860
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P2860
The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
The soluble extracellular doma ...... is, and inhibits tumor growth.
@ast
The soluble extracellular doma ...... is, and inhibits tumor growth.
@en
type
label
The soluble extracellular doma ...... is, and inhibits tumor growth.
@ast
The soluble extracellular doma ...... is, and inhibits tumor growth.
@en
prefLabel
The soluble extracellular doma ...... is, and inhibits tumor growth.
@ast
The soluble extracellular doma ...... is, and inhibits tumor growth.
@en
P2093
P2860
P1433
P1476
The soluble extracellular doma ...... is, and inhibits tumor growth.
@en
P2093
Lucy Leshanski
Nathalie Kertesz
Parkash S Gill
Ramachandra Reddy
S Ram Kumar
Valery Krasnoperov
P2860
P304
P356
10.1182/BLOOD-2005-04-1655
P407
P577
2005-12-01T00:00:00Z