Angiotensin II type 1 and type 2 receptors play opposite roles in regulating the barrier function of kidney glomerular capillary wall. - Wikidata - wikimedia - TriplyDB

Angiotensin II type 1 and type 2 receptors play opposite roles in regulating the barrier function of kidney glomerular capillary wall.

Angiotensin II type 1 and type 2 receptors play opposite roles in regulating the barrier function of kidney glomerular capillary wall.

http://www.wikidata.org/entity/Q35855619

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Angiotensin II has acute effects on TRPC6 channels in podocytes of freshly isolated glomeruli.The Role of Angiotensin II in Glomerular Volume Dynamics and Podocyte Calcium Handling.Mineralocorticoid receptor blockade enhances the antiproteinuric effect of an angiotensin II blocker through inhibiting podocyte injury in type 2 diabetic rats.Angiotensin receptor blocker protection against podocyte-induced sclerosis is podocyte angiotensin II type 1 receptor-independent.Angiotensin II induces nephrin dephosphorylation and podocyte injury: role of caveolin-1 Regression of superficial glomerular podocyte injury in type 2 diabetic rats with overt albuminuria: effect of angiotensin II blockade HIV-associated nephropathy: role of AT2R.Early treatment with olmesartan prevents juxtamedullary glomerular podocyte injury and the onset of microalbuminuria in type 2 diabetic rats.Involvement of glomerular renin-angiotensin system (RAS) activation in the development and progression of glomerular injury.ARB protects podocytes from HIV-1 nephropathy independently of podocyte AT1.High salt intake causes adverse fetal programming--vascular effects beyond blood pressure Angiotensin II Modulates p130Cas of Podocytes by the Suppression of AMP-Activated Protein Kinase.Role of calcineurin (CN) in kidney glomerular podocyte: CN inhibitor ameliorated proteinuria by inhibiting the redistribution of CN at the slit diaphragm.Angiotensin II blockade and renal protection.Strict angiotensin blockade prevents the augmentation of intrarenal angiotensin II and podocyte abnormalities in type 2 diabetic rats with microalbuminuria.Immune and inflammatory role in renal disease.Oxidative stress in hypertension: role of the kidney.Losartan chemistry and its effects via AT1 mechanisms in the kidney The angiotensin II type 2 receptor in renal disease.Renin-angiotensin system within the diabetic podocyte.Podocyte directed therapy of nephrotic syndrome-can we bring the inside out?A case of secondary focal segmental glomerulosclerosis associated with malignant hypertension Multivalent targeting of AT1 receptors with angiotensin II-functionalized nanoparticles.Deficiency of the Angiotensinase Aminopeptidase A Increases Susceptibility to Glomerular Injury.Targeting the angiotensin II type 2 receptor (AT2R) in colorectal liver metastases.Stretch reduces nephrin expression via an angiotensin II-AT(1)-dependent mechanism in human podocytes: effect of rosiglitazone.Angiotensin II receptor blockade inhibits acute glomerular injuries with the alteration of receptor expression.Role of kidney ADP-ribosyl cyclase in diabetic nephropathy.Time-course reduction of renal function in rats on high sodium intake: acute reversal by potassium canrenoate.Role of 12-lipoxygenase in decreasing P-cadherin and increasing angiotensin II type 1 receptor expression according to glomerular size in type 2 diabetic rats.AT2 R deficiency mediated podocyte loss via activation of ectopic hedgehog interacting protein (Hhip) gene expression.Transplantation of bone marrow-derived MSCs improves renal function and Na++K+-ATPase activity in rats with renovascular hypertension.Possible role for glomerular-derived angiotensinogen in nephrotic syndrome.Nephrin-Binding Ephrin-B1 at the Slit Diaphragm Controls Podocyte Function through the JNK Pathway.Actin dynamics at focal adhesions: a common endpoint and putative therapeutic target for proteinuric kidney diseases.Aggravated renal tubular damage and interstitial fibrosis in mice lacking guanylyl cyclase-A (GC-A), a receptor for atrial and B-type natriuretic peptides.

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Angiotensin II type 1 and type 2 receptors play opposite roles in regulating the barrier function of kidney glomerular capillary wall.

http://www.wikidata.org/entity/Q35855619

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The American Journal of Pathology

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Fujio Shimizu

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Gi Dong Han

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Hiroko Koike

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Hiroshi Kawachi

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Koichi Suzuki

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Naoko Miyauchi

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Taeko Hashimoto

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Takeshi Nakatsue

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Yumiko Fujioka

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P2860

Positionally cloned gene for a novel glomerular protein--nephrin--is mutated in congenital nephrotic syndrome

Nephrin is specifically located at the slit diaphragm of glomerular podocytes

International union of pharmacology. XXIII. The angiotensin II receptors

Nephrin redistribution on podocytes is a potential mechanism for proteinuria in patients with primary acquired nephrotic syndrome

Cloning of rat nephrin: expression in developing glomeruli and in proteinuric states

Cardiac-specific overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor-mediated pressor and chronotropic effects

Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy

The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer.

Roles of the podocyte in glomerular function.

Nephritogenic mAb 5-1-6 is directed at the extracellular domain of rat nephrin

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