about
Interactions of metals and Apolipoprotein E in Alzheimer's diseaseAlzheimer mechanisms and therapeutic strategiesLRRK2 transport is regulated by its novel interacting partner Rab32Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastinLRRK2 phosphorylates novel tau epitopes and promotes tauopathyTemperature and toxic Tau in Alzheimer's disease: new insightsTau Protein Hyperphosphorylation and Aggregation in Alzheimer's Disease and Other Tauopathies, and Possible Neuroprotective StrategiesTau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic ParaplegiaFrontotemporal lobar degeneration: old knowledge and new insight into the pathogenetic mechanisms of tau mutationsMechanisms of stress in the brainNeurodegeneration and microtubule dynamics: death by a thousand cutsMisframed ubiquitin and impaired protein quality control: an early event in Alzheimer's diseaseTargeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseasesPhysiological and pathological phosphorylation of tau by Cdk5Neuroinflammation in Alzheimer's diseaseThe role of tau in neurodegenerative diseases and its potential as a therapeutic targetTau-targeted treatment strategies in Alzheimer's diseaseAcetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment.Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy modelReactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain.Tau overexpression impacts a neuroinflammation gene expression network perturbed in Alzheimer's diseaseNeurodegeneration in a Drosophila model for the function of TMCC2, an amyloid protein precursor-interacting and apolipoprotein E-binding proteinDirect force measurements reveal that protein Tau confers short-range attractions and isoform-dependent steric stabilization to microtubules.Tau Protein Mediates APP Intracellular Domain (AICD)-Induced Alzheimer's-Like Pathological Features in MiceThe dendritic hypothesis for Alzheimer's disease pathophysiology.The contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's diseaseTau physiology and pathomechanisms in frontotemporal lobar degenerationModeling the complex pathology of Alzheimer's disease in DrosophilaTau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brainAβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic lossFisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factorsSynaptic protein α1-takusan mitigates amyloid-β-induced synaptic loss via interaction with tau and postsynaptic density-95 at postsynaptic sitesMicrotubule-associated protein tau is essential for long-term depression in the hippocampusFrontotemporal Dementia.Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-βmTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies.Amyloid-β oligomers induce tau-independent disruption of BDNF axonal transport via calcineurin activation in cultured hippocampal neuronsImmunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathy.Single-molecule tracking of tau reveals fast kiss-and-hop interaction with microtubules in living neuronsSmall molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AβPP(L/S) transgenic mice.
P2860
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P2860
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
The many faces of tau
@ast
The many faces of tau
@en
type
label
The many faces of tau
@ast
The many faces of tau
@en
prefLabel
The many faces of tau
@ast
The many faces of tau
@en
P2093
P2860
P1433
P1476
The many faces of tau
@en
P2093
Keith Vossel
Lennart Mucke
Sumihiro Maeda
P2860
P304
P356
10.1016/J.NEURON.2011.04.009
P407
P577
2011-05-01T00:00:00Z