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Spatial organization of the mouse genome and its role in recurrent chromosomal translocations

Spatial organization of the mouse genome and its role in recurrent chromosomal translocations

http://www.wikidata.org/entity/Q35874015

about

Roles of long noncoding RNAs in chromosome domains Choreographing the Double Strand Break Response: Ubiquitin and SUMO Control of Nuclear Architecture Pairing and anti-pairing: a balancing act in the diploid genome Analysis methods for studying the 3D architecture of the genome An Overview of Genome Organization and How We Got There: from FISH to Hi-C High-throughput sequencing for biology and medicine Complex correlations: replication timing and mutational landscapes during cancer and genome evolution Mechanisms of epigenetic regulation of leukemia onset and progression Chromothripsis, an unexpected novel form of complexity for chromosomal rearrangements Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination Epigenomics: the science of no-longer-junk DNA. Why study it in chronic kidney disease?DNA double-strand-break complexity levels and their possible contributions to the probability for error-prone processing and repair pathway choice Neocentromeres and epigenetically inherited features of centromeres Fractal dimension of chromatin: potential molecular diagnostic applications for cancer prognosis Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures.Emerging concepts of epigenetic dysregulation in hematological malignancies Making Sense of the Tangle: Insights into Chromatin Folding and Gene Regulation Building up the nucleus: nuclear organization in the establishment of totipotency and pluripotency during mammalian development Convergent transcription at intragenic super-enhancers targets AID-initiated genomic instability C-ing the Genome: A Compendium of Chromosome Conformation Capture Methods to Study Higher-Order Chromatin Organization The statistical-mechanics of chromosome conformation capture Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours Understanding spatial organizations of chromosomes via statistical analysis of Hi-C data Exploiting native forces to capture chromosome conformation in mammalian cell nuclei Two ways to fold the genome during the cell cycle: insights obtained with chromosome conformation capture Iterative correction of Hi-C data reveals hallmarks of chromosome organization.Chromatin associations in Arabidopsis interphase nuclei Identifying multi-locus chromatin contacts in human cells using tethered multiple 3C Grabbing the genome by the NADs Combining a wavelet change point and the Bayes factor for analysing chromosomal interaction data.Integrating multi-omic features exploiting Chromosome Conformation Capture data.Catching genomic rearrangements in the act: Integrating DNA breakage models and functional genomics data: (comment on DOI 10.1002/bies.201400174).Probing long-range interactions by extracting free energies from genome-wide chromosome conformation capture data.HiCdat: a fast and easy-to-use Hi-C data analysis tool.Genomic interaction profiles in breast cancer reveal altered chromatin architecture.The Genome Conformation As an Integrator of Multi-Omic Data: The Example of Damage Spreading in Cancer Statistical challenges in analyzing methylation and long-range chromosomal interaction data Eμ and 3'RR IgH enhancers show hierarchic unilateral dependence in mature B-cells.Generation and repair of AID-initiated DNA lesions in B lymphocytes.Organization of the mitotic chromosome.

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Spatial organization of the mouse genome and its role in recurrent chromosomal translocations

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Spatial organization of the mo ...... ent chromosomal translocations

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Spatial organization of the mo ...... ent chromosomal translocations

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Spatial organization of the mo ...... ent chromosomal translocations

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Aline C Simon

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Bryan R Lajoie

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Dominic G Hildebrand

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P2860

Three-dimensional maps of all chromosomes in human male fibroblast nuclei and prometaphase rosettes.

Common themes and cell type specific variations of higher order chromatin arrangements in the mouse

Massive genomic rearrangement acquired in a single catastrophic event during cancer development

Complex landscapes of somatic rearrangement in human breast cancer genomes.

DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes

Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination

Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses

The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations

Comprehensive mapping of long-range interactions reveals folding principles of the human genome

Capturing chromosome conformation

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Rachel Patton McCord

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