Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases.
about
Centrally acting oximes in reactivation of tabun-phosphoramidated AChE.Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugatesA comprehensive evaluation of the efficacy of leading oxime therapies in guinea pigs exposed to organophosphorus chemical warfare agents or pesticides.Resolving pathways of interaction of mipafox and a sarin analog with human acetylcholinesterase by kinetics, mass spectrometry and molecular modeling approaches.Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by OrganophosphatesCatalytic detoxification of nerve agent and pesticide organophosphates by butyrylcholinesterase assisted with non-pyridinium oximes.Novel brain-penetrating oximes for reactivation of cholinesterase inhibited by sarin and VX surrogates.Drug development for the management of organophosphorus poisoning.Transformation of saturated nitrogen-containing heterocyclic compounds by microorganisms.Post-exposure treatment with the oxime RS194B rapidly reverses early and advanced symptoms in macaques exposed to sarin vapor.SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides.Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Cholinesterase reactivators and bioscavengers for pre- and post-exposure treatments of organophosphorus poisoning.Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016).Mechanistic studies of new oximes reactivators of human butyryl cholinesterase inhibited by cyclosarin and sarin.Translation of in vitro to in vivo pyridinium oxime potential in tabun poisoning.Planarian cholinesterase: in vitro characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity and reactivation.Syrian gas attack reinforces need for better anti-sarin drugs.Preclinical studies of noncharged oxime reactivators for organophosphate exposure.Post-exposure treatment with the oxime RS194B rapidly reactivates and reverses advanced symptoms of lethal inhaled paraoxon in macaques.Behavior of uncharged oximes compared to HI6 and 2-PAM in the human AChE-tabun conjugate: a molecular modeling approach.The biodistribution and pharmacokinetics of the oxime acetylcholinesterase reactivator RS194B in guinea pigs.
P2860
Q34409251-7EB0762B-917B-4323-A706-4CF302BB3F09Q34414091-5050126D-0F73-4479-AA07-03FCA6608699Q34628506-682D1BFF-066C-4367-9022-1ACE0A04E492Q35572473-77CB61F9-A518-4340-AD1F-0F333AB70B7AQ36331614-210E1C3C-634C-43D6-820F-4D6690ED02E2Q36635142-D2C57FB5-52E7-49EE-A430-E91D5F829371Q37083568-8FA6EA6A-0578-4BE8-84FC-3F7F1AA7C33BQ38152506-A974E024-64CE-4EAF-9B02-EBC01084EFD4Q38172427-2992EF19-32B9-4BB8-BF2F-D914EFB83667Q38685670-8D6BE49B-22E4-4BB4-8DAB-1E534B5377C1Q38942948-4E21934E-760D-45B2-861D-63F03AE4E107Q39038234-96F3CBD6-C2A4-4EE5-BC46-389D04E479A8Q39329265-B68D3BDB-DD1A-47D9-B55D-8F9E391938E1Q39343521-28623EAF-CFFC-492B-ADA5-99782ABFCCF9Q39812909-1DC23414-24B3-4982-8325-DFCA0B733263Q40123151-A15D3DB3-EE44-4AD3-B40F-2EBB1A44F1BBQ43969490-E38CD9C0-1BC4-4D24-923B-DCB7B3BB8512Q44771834-BEF1E7F6-898C-4EDA-8E52-CE9EB714B6FBQ45874550-4EEB41EC-F05F-4B5C-A99B-9EB62CDA81A3Q46314151-B55054CB-7202-47A4-B310-A793EFA77325Q46376157-5C90351E-3F5D-4468-8E77-44DDF10C40A5Q46950790-5D2ADE3B-2EEC-484D-96E1-D139D13289E5
P2860
Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Refinement of structural leads ...... phosphylated cholinesterases.
@ast
Refinement of structural leads ...... phosphylated cholinesterases.
@en
type
label
Refinement of structural leads ...... phosphylated cholinesterases.
@ast
Refinement of structural leads ...... phosphylated cholinesterases.
@en
prefLabel
Refinement of structural leads ...... phosphylated cholinesterases.
@ast
Refinement of structural leads ...... phosphylated cholinesterases.
@en
P2093
P2860
P356
P1476
Refinement of structural leads ...... phosphylated cholinesterases.
@en
P2093
Bozica Radić
Carol Green
Edzna Garcia
Gabriel Amitai
Limin Zhang
Palmer Taylor
Rakesh K Sit
Suzana Berend
Zoran Radić
Zrinka Kovarik
P2860
P304
11798-11809
P356
10.1074/JBC.M111.333732
P407
P577
2012-02-16T00:00:00Z