Minocycline attenuates microglia activation and blocks the long-term epileptogenic effects of early-life seizures. - Wikidata - wikimedia - TriplyDB

Minocycline attenuates microglia activation and blocks the long-term epileptogenic effects of early-life seizures.

Minocycline attenuates microglia activation and blocks the long-term epileptogenic effects of early-life seizures.

http://www.wikidata.org/entity/Q35881742

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Novel frontiers in epilepsy treatments: preventing epileptogenesis by targeting inflammation Pro-epileptogenic effects of viral-like inflammation in both mature and immature brains.Activated microglia contribute to neuronal apoptosis in Toxoplasmic encephalitis.Minocycline upregulates cyclic AMP response element binding protein and brain-derived neurotrophic factor in the hippocampus of cerebral ischemia rats and improves behavioral deficits Antidepressant use and risk of epilepsy and seizures in people aged 20 to 64 years: cohort study using a primary care database.Lipopolysaccharide potentiates hyperthermia-induced seizures.Infiltrating macrophages are key to the development of seizures following virus infection.Pyrrolidine dithiocarbamate (PDTC) inhibits the overexpression of MCP-1 and attenuates microglial activation in the hippocampus of a pilocarpine-induced status epilepticus rat model.Everolimus is better than rapamycin in attenuating neuroinflammation in kainic acid-induced seizures.Intranasal Delivery of miR-146a Mimics Delayed Seizure Onset in the Lithium-Pilocarpine Mouse Model.Activation of brain indoleamine 2,3-dioxygenase contributes to epilepsy-associated depressive-like behavior in rats with chronic temporal lobe epilepsy.Neurosteroids and epileptogenesis.Pathophysiogenesis of mesial temporal lobe epilepsy: is prevention of damage antiepileptogenic?Inflammation and epilepsy in the developing brain: clinical and experimental evidence.Neuroinflammatory targets and treatments for epilepsy validated in experimental models.Modulators of microglia: a patent review.Microglia-Neuron Communication in Epilepsy.Progress report on new antiepileptic drugs: A summary of the Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIII).Microglia are less pro-inflammatory than myeloid infiltrates in the hippocampus of mice exposed to status epilepticus.The effect of IL-1β on synaptophysin expression and electrophysiology of hippocampal neurons through the PI3K/Akt/mTOR signaling pathway in a rat model of mesial temporal lobe epilepsy.Acute treatment with minocycline, but not valproic acid, improves long-term behavioral outcomes in the Theiler's virus model of temporal lobe epilepsy.Microglial activation during epileptogenesis in a mouse model of tuberous sclerosis complex.Confounding effect of EEG implantation surgery: Inadequacy of surgical control in a two hit model of temporal lobe epilepsy.Spinal microglial activation in a murine surgical model of knee osteoarthritis.Effect of minocycline on pentylenetetrazol-induced chemical kindled seizures in mice.Early-life febrile seizures worsen adult phenotypes in Scn1a mutants.A 2017 review of pharmacotherapy for treating focal epilepsy: where are we now and how will treatment develop?Role of Neuroinflammation in Evolution of Childhood Epilepsy.A resurging boom in new drugs for epilepsy and brain disorders.Interleukin-1β and microRNA-146a in an immature rat model and children with mesial temporal lobe epilepsy.Inhibitor effect of paricalcitol in rat model of pentylenetetrazol-induced seizures.Chronic Trigeminal Nerve Stimulation Protects Against Seizures, Cognitive Impairments, Hippocampal Apoptosis, and Inflammatory Responses in Epileptic Rats.Microglia and CNS Interleukin-1: Beyond Immunological Concepts.Investigational new drugs for focal epilepsy.The role of the microRNA-146a/complement factor H/interleukin-1β-mediated inflammatory loop circuit in the perpetuate inflammation of chronic temporal lobe epilepsy.Noninflammatory Changes of Microglia Are Sufficient to Cause Epilepsy.Brain Inflammation in an Infant With Hemimegalencephaly, Escalating Seizures, and Epileptic Encephalopathy.Microglia after Seizures and in Epilepsy.In Utero Administration of Drugs Targeting Microglia Improves the Neurodevelopmental Outcome Following Cytomegalovirus Infection of the Rat Fetal Brain.In Utero Administration of Drugs Targeting Microglia Improves the Neurodevelopmental Outcome Following Cytomegalovirus Infection of the Rat Fetal Brain.

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P2860

Minocycline attenuates microglia activation and blocks the long-term epileptogenic effects of early-life seizures.

http://www.wikidata.org/entity/Q35881742

description

2012 nî lūn-bûn

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name

Minocycline attenuates microgl ...... ffects of early-life seizures.

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Minocycline attenuates microgl ...... ffects of early-life seizures.

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type

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Minocycline attenuates microgl ...... ffects of early-life seizures.

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Minocycline attenuates microgl ...... ffects of early-life seizures.

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Minocycline attenuates microgl ...... ffects of early-life seizures.

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Minocycline attenuates microgl ...... ffects of early-life seizures.

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J.NBD.2012.02.006

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Neurobiology of Disease

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Minocycline attenuates microgl ...... ffects of early-life seizures.

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Alyssa Bartolini

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Carlo Condello

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Jayne Abraham

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Patrick D Fox

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Sookyong Koh

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P2860

TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease

Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia

Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy

The emerging role for chemokines in epilepsy

ATP mediates rapid microglial response to local brain injury in vivo

Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion

Neuroglial activation and neuroinflammation in the brain of patients with autism

A role for leukocyte-endothelial adhesion mechanisms in epilepsy

Effect of lipopolysaccharide on the morphology and integrin immunoreactivity of ramified microglia in the mouse brain and in cell culture.

PEG minocycline-liposomes ameliorate CNS autoimmune disease.

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